82 research outputs found
Factors relating to the mental health of women who were pregnant at the time of the Great East Japan earthquake: analysis from month 10 to month 48 after the earthquake
Crystallographic and superconducting properties of the fully-gapped noncentrosymmetric 5d-electron superconductors CaMSi3 (M=Ir, Pt)
We report crystallographic, specific heat, transport, and magnetic properties
of the recently discovered noncentrosymmetric 5d-electron superconductors
CaIrSi3 (Tc = 3.6 K) and CaPtSi3 (Tc = 2.3 K). The specific heat suggests that
these superconductors are fully gapped. The upper critical fields are less than
1 T, consistent with limitation by conventional orbital depairing. High,
non-Pauli-limited {\mu}0 Hc2 values, often taken as a key signature of novel
noncentrosymmetric physics, are not observed in these materials because the
high carrier masses required to suppress orbital depairing and reveal the
violated Pauli limit are not present.Comment: 8 pages, 8 figure
Seismic Performance of Isolated Bridges Considering Long-term Deterioration of Isolators
Mechanical properties of natural rubber seismic isolators are varied due to aging deterioration. It is needed that seismic performance of isolated bridges are maintained considering aging deterioration of isolators over their lifetime. In this study, seismic failure modes and seismic safety of isolated bridges were evaluated considering uncertainties in the material and mechanical properties and aging deterioration of isolators. It was shown that seismic safety of the isolated bridges is mainly controlled by the rupture strain of the isolator if the ultimate capacity ratio between the isolator and the column is low and that adequate capacity ratio is needed to enhance seismic safety and reparability of isolated bridges
Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light
Although light is essential for photosynthesis, it has the potential to elevate intracellular levels of reactive oxygen species (ROS). Since high ROS levels are cytotoxic, plants must alleviate such damage. However, the cellular mechanism underlying ROS-induced leaf damage alleviation in peroxisomes was not fully explored. Here, we show that autophagy plays a pivotal role in the selective removal of ROS-generating peroxisomes, which protects plants from oxidative damage during photosynthesis. We present evidence that autophagy-deficient mutants show light intensity-dependent leaf damage and excess aggregation of ROS-accumulating peroxisomes. The peroxisome aggregates are specifically engulfed by pre-autophagosomal structures and vacuolar membranes in both leaf cells and isolated vacuoles, but they are not degraded in mutants. ATG18a-GFP and GFP-2×FYVE, which bind to phosphatidylinositol 3-phosphate, preferentially target the peroxisomal membranes and pre-autophagosomal structures near peroxisomes in ROS-accumulating cells under high-intensity light. Our findings provide deeper insights into the plant stress response caused by light irradiation
Factors relating to the mental health of women who were pregnant at the time of the Great East Japan earthquake: analysis from month 10 to month 48 after the earthquake
Effects of Baseline Blood Pressure and Low-Density Lipoprotein Cholesterol on Safety and Efficacy of Canagliflozin in Japanese Patients with Type 2 Diabetes Mellitus
First Case of Echinococcus multilocularis Infection in a Zoo-Housed Flying Squirrel (Pteromys volans orii)
Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions
Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process. However, quantitative prediction of oral absorption from ASDs is still difficult. Supersaturated solutions can cause liquid-liquid phase separation through the spinodal decomposition mechanism, which must be adequately comprehended to understand the oral absorption of drugs quantitatively. In this study, albendazole (ALZ) was formulated into ASDs using three types of polymers, poly(methacrylic acid-co-methyl methacrylate) (Eudragit) L100, Vinylpyrrolidone-vinyl acetate copolymer (PVPVA), and hydroxypropyl methylcellulose acetate succinate (HPMCAS). The oral absorption of ALZ in rats administered as ASD suspensions was not explained by dissolution study but was predicted using liquid-liquid phase separation concentration, which suggested that the absorption of ALZ was solubility-limited. The oral administration study in dogs performed using solid capsules demonstrated the low efficacy of ASDs because the absorption was likely to be limited by dissolution rate, which indicated the importance of designing the final dosage form of the ASDs
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