105 research outputs found
<Abstract of published report>Distinct Solvent-dependence in the Photoreactions of Purine Nucleosides with Pyrimido[5,4-g]pteridinetetrone N-Oxide : Possible Generation of Hydroxyl Radical from the Excited N-Oxide in Alcohols.
<Abstract of published report>N^6-Substituent Effect on the Photooxidation of 2\u27, 3\u27-O-Isopropylideneadenosines with a Pyrimido[5,4-g]pteridinetetraone N-Oxide. : Chemical Evidence for the Generation and Reactivity of Adenosyl Cation Radicals.
Congenital atrophic dermatofibrosarcoma protuberans detected by COL1A1-PDGFB rearrangement
Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis
Rs in cardiogenesis remain unclear.Rs mimicked the phenotype of the AV valve defect that result from the inhibition of calcineurin, and it could be rescued by constitutively active calcineurin.Rs in cardiogenesis in part through the regulation of calcineurin-NFAT signaling
Clamp loader ATPases and the evolution of DNA replication machinery
Clamp loaders are pentameric ATPases of the AAA+ family that operate to ensure processive DNA replication. They do so by loading onto DNA the ring-shaped sliding clamps that tether the polymerase to the DNA. Structural and biochemical analysis of clamp loaders has shown how, despite differences in composition across different branches of life, all clamp loaders undergo the same concerted conformational transformations, which generate a binding surface for the open clamp and an internal spiral chamber into which the DNA at the replication fork can slide, triggering ATP hydrolysis, release of the clamp loader, and closure of the clamp round the DNA. We review here the current understanding of the clamp loader mechanism and discuss the implications of the differences between clamp loaders from the different branches of life
Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection
Measurement of the differences in the total cross section for antiparallel and parallel longitudinal spins and a measurement of parity nonconservation with incident polarized protons and antiprotons at 200 GeV/c
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