Dynamic Image-Based Modelling of Kidney Branching Morphogenesis

Kidney branching morphogenesis has been studied extensively, but the mechanism that defines the branch points is still elusive. Here we obtained a 2D movie of kidney branching morphogenesis in culture to test different models of branching morphogenesis with physiological growth dynamics. We carried out image segmentation and calculated the displacement fields between the frames. The models were subsequently solved on the 2D domain, that was extracted from the movie. We find that Turing patterns are sensitive to the initial conditions when solved on the epithelial shapes. A previously proposed diffusion-dependent geometry effect allowed us to reproduce the growth fields reasonably well, both for an inhibitor of branching that was produced in the epithelium, and for an inducer of branching that was produced in the mesenchyme. The latter could be represented by Glial-derived neurotrophic factor (GDNF), which is expressed in the mesenchyme and induces outgrowth of ureteric branches. Considering that the Turing model represents the interaction between the GDNF and its receptor RET very well and that the model reproduces the relevant expression patterns in developing wildtype and mutant kidneys, it is well possible that a combination of the Turing mechanism and the geometry effect control branching morphogenesis

Series study of the One-dimensional S-T Spin-Orbital Model

We use perturbative series expansions about a staggered dimerized ground state to compute the ground state energy, triplet excitation spectra and spectral weight for a one-dimensional model in which each site has an S=\case 1/2 spin ${\bf S}_i$ and a pseudospin ${\bf T}_i$, representing a doubly degenerate orbital. An explicit dimerization is introduced to allow study of the confinement of spinon excitations. The elementary triplet represents a bound state of two spinons, and is stable over much of the Brillouine zone. A special line is found in the gapped spin-liquid phase, on which the triplet excitation is dispersionless. The formation of triplet bound states is also investigated.Comment: 9 pages, 9 figure

Zero temperature phases of the frustrated J1-J2 antiferromagnetic spin-1/2 Heisenberg model on a simple cubic lattice

At zero temperature magnetic phases of the quantum spin-1/2 Heisenberg antiferromagnet on a simple cubic lattice with competing first and second neighbor exchanges (J1 and J2) is investigated using the non-linear spin wave theory. We find existence of two phases: a two sublattice Neel phase for small J2 (AF), and a collinear antiferromagnetic phase at large J2 (CAF). We obtain the sublattice magnetizations and ground state energies for the two phases and find that there exists a first order phase transition from the AF-phase to the CAF-phase at the critical transition point, pc = 0.28. Our results for the value of pc are in excellent agreement with results from Monte-Carlo simulations and variational spin wave theory. We also show that the quartic 1/S corrections due spin-wave interactions enhance the sublattice magnetization in both the phases which causes the intermediate paramagnetic phase predicted from linear spin wave theory to disappear.Comment: 19 pages, 4 figures, Fig. 1b modified, Appendix B text modifie

The partition function of interfaces from the Nambu-Goto effective string theory

We consider the Nambu-Goto bosonic string model as a description of the physics of interfaces. By using the standard covariant quantization of the bosonic string, we derive an exact expression for the partition function in dependence of the geometry of the interface. Our expression, obtained by operatorial methods, resums the loop expansion of the NG model in the "physical gauge" computed perturbatively by functional integral methods in the literature. Recently, very accurate Monte Carlo data for the interface free energy in the 3d Ising model became avaliable. Our proposed expression compares very well to the data for values of the area sufficiently large in terms of the inverse string tension. This pattern is expected on theoretical grounds and agrees with previous analyses of other observables in the Ising model.Comment: 28 pages, 4 figure

Maxwell's field coupled nonminimally to quadratic torsion: Induced axion field and birefringence of the vacuum

We consider a possible (parity conserving) interaction between the electromagnetic field $F$ and a torsion field $T^\alpha$ of spacetime. For generic elementary torsion, gauge invariant coupling terms of lowest order fall into two classes that are both nonminimal and {\it quadratic} in torsion. These two classes are displayed explicitly. The first class of the type $\sim F T^2$ yields (undesirable) modifications of the Maxwell equations. The second class of the type $\sim F^2 T^2$ doesn't touch the Maxwell equations but rather modifies the constitutive tensor of spacetime. Such a modification can be completely described in the framework of metricfree electrodynamics. We recognize three physical effects generated by the torsion: (i) An axion field that induces an {\em optical activity} into spacetime, (ii) a modification of the light cone structure that yields {\em birefringence} of the vacuum, and (iii) a torsion dependence of the {\em velocity of light.} We study these effects in the background of a Friedmann universe with torsion. {\it File tor17.tex, 02 August 2003}Comment: 6 page

The spectral gap for some spin chains with discrete symmetry breaking

We prove that for any finite set of generalized valence bond solid (GVBS) states of a quantum spin chain there exists a translation invariant finite-range Hamiltonian for which this set is the set of ground states. This result implies that there are GVBS models with arbitrary broken discrete symmetries that are described as combinations of lattice translations, lattice reflections, and local unitary or anti-unitary transformations. We also show that all GVBS models that satisfy some natural conditions have a spectral gap. The existence of a spectral gap is obtained by applying a simple and quite general strategy for proving lower bounds on the spectral gap of the generator of a classical or quantum spin dynamics. This general scheme is interesting in its own right and therefore, although the basic idea is not new, we present it in a system-independent setting. The results are illustrated with an number of examples.Comment: 48 pages, Plain TeX, BN26/Oct/9

High-Order Coupled Cluster Method (CCM) Calculations for Quantum Magnets with Valence-Bond Ground States

In this article, we prove that exact representations of dimer and plaquette valence-bond ket ground states for quantum Heisenberg antiferromagnets may be formed via the usual coupled cluster method (CCM) from independent-spin product (e.g. N\'eel) model states. We show that we are able to provide good results for both the ground-state energy and the sublattice magnetization for dimer and plaquette valence-bond phases within the CCM. As a first example, we investigate the spin-half $J_1$--$J_2$ model for the linear chain, and we show that we are able to reproduce exactly the dimerized ground (ket) state at $J_2/J_1=0.5$. The dimerized phase is stable over a range of values for $J_2/J_1$ around 0.5. We present evidence of symmetry breaking by considering the ket- and bra-state correlation coefficients as a function of $J_2/J_1$. We then consider the Shastry-Sutherland model and demonstrate that the CCM can span the correct ground states in both the N\'eel and the dimerized phases. Finally, we consider a spin-half system with nearest-neighbor bonds for an underlying lattice corresponding to the magnetic material CaV$_4$O$_9$ (CAVO). We show that we are able to provide excellent results for the ground-state energy in each of the plaquette-ordered, N\'eel-ordered, and dimerized regimes of this model. The exact plaquette and dimer ground states are reproduced by the CCM ket state in their relevant limits.Comment: 34 pages, 13 figures, 2 table

Particle density fluctuations

Event-by-event fluctuations in the multiplicities of charged particles and photons at SPS energies are discussed. Fluctuations are studied by controlling the centrality of the reaction and rapidity acceptance of the detectors. Results are also presented on the event-by-event study of correlations between the multiplicity of charged particles and photons to search for DCC-like signals.Comment: Talk presented at Quark Matter 2002, Nantes, Franc

Suppression of High-p_T Neutral Pion Production in Central Pb+Pb Collisions at sqrt{s_NN} = 17.3 GeV Relative to p+C and p+Pb Collisions

Neutral pion transverse momentum spectra were measured in p+C and p+Pb collisions at sqrt{s_NN} = 17.4 GeV at mid-rapidity 2.3 < eta_lab < 3.0 over the range 0.7< p_T < 3.5 GeV/c. The spectra are compared to pi0 spectra measured in Pb+Pb collisions at sqrt{s_NN} = 17.3 GeV in the same experiment. For a wide range of Pb+Pb centralities (N_part < 300) the yield of pi0's with p_T > 2 GeV/c is larger than or consistent with the p+C or p+Pb yields scaled with the number of nucleon-nucleon collisions (N_coll), while for central Pb+Pb collisions with N_part > 350 the pi0 yield is suppressed.Comment: 5 pages, 4 figure

Gravitational Lensing by Black Holes

We review the theoretical aspects of gravitational lensing by black holes, and discuss the perspectives for realistic observations. We will first treat lensing by spherically symmetric black holes, in which the formation of infinite sequences of higher order images emerges in the clearest way. We will then consider the effects of the spin of the black hole, with the formation of giant higher order caustics and multiple images. Finally, we will consider the perspectives for observations of black hole lensing, from the detection of secondary images of stellar sources and spots on the accretion disk to the interpretation of iron K-lines and direct imaging of the shadow of the black hole.Comment: Invited article for the GRG special issue on lensing (P. Jetzer, Y. Mellier and V. Perlick Eds.). 31 pages, 12 figure