THE CHOICE OF FINANCIAL PERFORMANCE MEASURES AS ONE OF THE MOST CRITICAL CHALLENGES FACING CORPORATION

The value-based measures are discussedby focusing on their measurement logic: The most important value-based measures are: economic value added (EVA), the cash flow return on investment (CFROI), the shareholder value added (SVA), the economic margin (EM) and the cash flow value added (CVA).The aim of this work is the collection and compilation materials about the Value Based Management (VBM) approach. Although an integral part of VBM-approach measures the value of the company, it fundamentally differs from traditional methods of the business evaluation, most of which give a "point" result and are isolated from management context and are snatched out of the ultimate goal and donot assume its monitoring

THE CHOICE OF FINANCIAL PERFORMANCE MEASURES AS ONE OF THE MOST CRITICAL CHALLENGES FACING CORPORATION

The value-based measures are discussedby focusing on their measurement logic: The most important value-based measures are: economic value added (EVA), the cash flow return on investment (CFROI), the shareholder value added (SVA), the economic margin (EM) and the cash flow value added (CVA).The aim of this work is the collection and compilation materials about the Value Based Management (VBM) approach. Although an integral part of VBM-approach measures the value of the company, it fundamentally differs from traditional methods of the business evaluation, most of which give a "point" result and are isolated from management context and are snatched out of the ultimate goal and donot assume its monitoring

Pyrimidoquinazolinophenanthroline Opens Next Chapter in Design of Bridging Ligands for Artificial Photosynthesis **

The synthesis and detailed characterization of a new Ru polypyridine complex containing a heteroditopic bridging ligand with previously unexplored metal‐metal distances is presented. Due to the twisted geometry of the novel ligand, the resultant division of the ligand in two distinct subunits leads to steady state as well as excited state properties of the corresponding mononuclear Ru(II) polypyridine complex resembling those of prototype [Ru(bpy) 3 ] 2+ (bpy=2,2'‐bipyridine). The localization of the initially optically excited and the nature of the long‐lived excited states on the Ru‐facing ligand spheres is evaluated by resonance Raman and fs‐TA spectroscopy, respectively, and supported by DFT and TDDFT calculations. Coordination of a second metal (Zn or Rh) to the available bis‐pyrimidyl‐like coordination sphere strongly influences the frontier orbitals, apparent by, for example, luminescence quenching. Thus, the new bridging ligand motif offers electronic properties, which can be adjusted by the nature of the second metal center. Using the heterodinuclear Ru−Rh complex, visible light‐driven reduction of NAD + to NADH was achieved, highlighting the potential of this system for photocatalytic applications

Retrospective mapping of the XVI century Samtskhe-Javakheti viticulture and fruit farming

The presented work deals with the spread of viticulture and fruit farming in the Middle Ages in the Samtskhe-Javakheti region in Georgia. The current state of the farming sectors mentioned and those pivotal moments in Georgian history that had an influence on agriculture are also considered in the article. The changes that determined the viticulture geography from the second part of the 16th century up to the present day are also discussed. The study is mainly based on the census document created in 1574. The article represents the geographic distribution patterns of vineyards and orchards, as well as wine production capacity and the fruit harvest. Retrospective mapping made it possible to restore the distribution of farms and gardens of the mentioned period and to analyse the importance of viticulture and fruit farming in the 16th century. The maps represented show spatial patterns of vineyards, gardens, and main terroirs

Retrospective mapping of the XVI century Samtskhe-Javakheti viticulture and fruit farming

The presented work deals with the spread of viticulture and fruit farming in the Middle Ages in the Samtskhe-Javakheti region in Georgia. The current state of the farming sectors mentioned and those pivotal moments in Georgian history that had an influence on agriculture are also considered in the article. The changes that determined the viticulture geography from the second part of the 16th century up to the present day are also discussed. The study is mainly based on the census document created in 1574. The article represents the geographic distribution patterns of vineyards and orchards, as well as wine production capacity and the fruit harvest. Retrospective mapping made it possible to restore the distribution of farms and gardens of the mentioned period and to analyse the importance of viticulture and fruit farming in the 16th century. The maps represented show spatial patterns of vineyards, gardens, and main terroirs

Landscapes, settlements and traditional housing in Samtskhe-Javakheti, Georgia

A change in livelihood and folk architecture is an indicator of cultural landscape transformation, which is often the result of changes occurring in the natural and socio-political realms. The diversity of architectural types of buildings as an element of landscape diversity distinguishes our research region. The presented study deals with a long-term change of housing and architectural types of settlements. Our goal was to identify, geolocalise, and classify the vernacular architecture of Samtskhe-Javakheti within the different types of natural landscapes. For this purpose, we used the HGIS (Historical Geoinformation System) approach, which comprises the application of both historic sources and GIS technologies. We identified seven types of buildings in the study area, the characteristics of which depended on the natural landscape features. The following factors had been determining the geography of the construction: geology, seismicity, terrain, climate, access to building materials and defence. Dominant architectural types of buildings in the study region were as follows: fortress Rabat with stone houses, stone houses, semi-underground houses mixed with stone houses, semi-underground houses, terraced semi-underground houses, cave dwellings and wooden log houses. In modern times, it is quite rare to come across these kinds of architectural buildings, and there is a tendency of their disappearance

Retrospective mapping of the XVI century Samtskhe-Javakheti viticulture and fruit farming

The presented work deals with the spread of viticulture and fruit farming in the Middle Ages in the Samtskhe-Javakheti region in Georgia. The current state of the farming sectors mentioned and those pivotal moments in Georgian history that had an influence on agriculture are also considered in the article. The changes that determined the viticulture geography from the second part of the 16th century up to the present day are also discussed. The study is mainly based on the census document created in 1574. The article represents the geographic distribution patterns of vineyards and orchards, as well as wine production capacity and the fruit harvest. Retrospective mapping made it possible to restore the distribution of farms and gardens of the mentioned period and to analyse the importance of viticulture and fruit farming in the 16th century. The maps represented show spatial patterns of vineyards, gardens, and main terroirs

Synthesis, Characterization, and In Vitro Cytotoxicity Evaluation of Doxorubicin-Loaded Magnetite Nanoparticles on Triple-Negative Breast Cancer Cell Lines

In this study, we investigated the cytotoxicity of doxorubicin (DOX)-loaded magnetic nanofluids on 4T1 mouse tumor epithelial cells and MDA-MB-468 human triple-negative breast cancer (TNBC) cells. Superparamagnetic iron oxide nanoparticles were synthesized using sonochemical coprecipitation by applying electrohydraulic discharge treatment (EHD) in an automated chemical reactor, modified with citric acid and loaded with DOX. The resulting magnetic nanofluids exhibited strong magnetic properties and maintained sedimentation stability in physiological pH conditions. The obtained samples were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy, UV-spectrophotometry, dynamic light scattering (DLS), electrophoretic light scattering (ELS), vibrating sample magnetometry (VSM), and transmission electron microscopy (TEM). In vitro studies using the MTT method revealed a synergistic effect of the DOX-loaded citric-acid-modified magnetic nanoparticles on the inhibition of cancer cell growth and proliferation compared to treatment with pure DOX. The combination of the drug and magnetic nanosystem showed promising potential for targeted drug delivery, with the possibility of optimizing the dosage to reduce side-effects and enhance the cytotoxic effect on cancer cells. The nanoparticles’ cytotoxic effects were attributed to the generation of reactive oxygen species and the enhancement of DOX-induced apoptosis. The findings suggest a novel approach for enhancing the therapeutic efficacy of anticancer drugs and reducing their associated side-effects. Overall, the results demonstrate the potential of DOX-loaded citric-acid-modified magnetic nanoparticles as a promising strategy in tumor therapy, and provide insights into their synergistic effects

Pyrimidoquinxoalinophenanthroline opens next chapter in design of bridging ligands for artificial photosynthesis

Using a dehydrogenative chemistry on the complex approach, a new polypyridine bridging ligand that bridges the gap of already existing systems is synthesized. By the usage of versatile cross-coupling reactions two different coordination spheres are included in the ligand architecture. Due to the twisted geometry of the novel ditopic ligand, the resultant division of the ligand in two distinct subunits leads to steady state as well as excited state properties of the corresponding mononuclear Ru(II) polypyridine complex resembling those of prototype [Ru(bpy)3]2+ (bpy = 2,2´-bipyridine). The localization of the initially optically excited and the nature of the long-lived excited states on the Ru-facing ligand spheres is evaluated by resonance Raman and fs-TA spectroscopy, respectively, and supported by DFT and TDDFT calculations. Coordination of a second metal (Zn or Rh) to the available bis-pyrimidyl-like coordination sphere strongly influences the frontier molecular orbitals apparent by e.g., luminescence quenching. Thus, the new bridging ligand motif offers electronic properties which can be adjusted by the nature of the second metal center. Using the heterodinuclear Ru-Rh complex, visible light-driven reduction of NAD+ to NADH was achieved, highlighting the potential of this system for photocatalytic applications