Morphofunctional changes of the rats placenta and ovaries under the influence of lead acetate and its combination with metal citrates

The formation of the rats fetus and placenta, functional state of rats ovaries under injection of lead acetate and its combined injection with citrate metals (gold, silver) during pregnancy was researched. Embryotoxic, gonadotoxic and placentotoxic effect of lead acetate in isolated injection was found, modifying effect of citrate metals on toxicity of lead acetate in combined injection was found

Morphological Features of Rats Placenta Under the Influence of Lead Acetateand its Combination with the Silver Citrate.

Виявлено негативний вплив розчину ацетату свинцю на процес ровитку плаценти щурів, що проявляється в затримці її розвитку та наявності дисциркуляторних порушень. При введенні ацетату свинцю комбіновано з цитратом срібла виявлено наближення показників до контрольних значень (діаметр, маса, співвідношення шарів, відносний об’єм лакун та ін.) Study was conducted on 120 white mature pregnant female rats Wistar. All animals were divided into 3 groups: 1st group – animals injected with solution of lead acetate at a dose of 0.05 mg/kg; 2nd group – animals injected with solution of lead acetate at a dose of 0.05 mg/kg and solution of silver citrate at a dose of 2 mcg/kg, n = 8; 3th subgroup –control, animals injected with distilled water. Solutions of heavy metals and nanometals were injected to pregnant female through a tube once a day, at one and the same time. Operative slaughter was performed on 16th and 20th day of pregnancy. The animals were taken out of the experiment by an overdose of ether anesthesia. The study showed negative effect of lead acetate on the process of development of the placenta in rats, which is manifested in the delay of its development and the presence of dyscirculatory violations. In case of the injection of lead acetate in combination with silver citrate found the approach to the indicators of control values (diameter, weight, value layers, the relative volume of the gaps, etc.)

Morphological Features of Rats Placenta Under the Influence of Lead Acetateand its Combination with the Silver Citrate.

Виявлено негативний вплив розчину ацетату свинцю на процес ровитку плаценти щурів, що проявляється в затримці її розвитку та наявності дисциркуляторних порушень. При введенні ацетату свинцю комбіновано з цитратом срібла виявлено наближення показників до контрольних значень (діаметр, маса, співвідношення шарів, відносний об’єм лакун та ін.) Study was conducted on 120 white mature pregnant female rats Wistar. All animals were divided into 3 groups: 1st group – animals injected with solution of lead acetate at a dose of 0.05 mg/kg; 2nd group – animals injected with solution of lead acetate at a dose of 0.05 mg/kg and solution of silver citrate at a dose of 2 mcg/kg, n = 8; 3th subgroup –control, animals injected with distilled water. Solutions of heavy metals and nanometals were injected to pregnant female through a tube once a day, at one and the same time. Operative slaughter was performed on 16th and 20th day of pregnancy. The animals were taken out of the experiment by an overdose of ether anesthesia. The study showed negative effect of lead acetate on the process of development of the placenta in rats, which is manifested in the delay of its development and the presence of dyscirculatory violations. In case of the injection of lead acetate in combination with silver citrate found the approach to the indicators of control values (diameter, weight, value layers, the relative volume of the gaps, etc.)