Dynamique des relations interpersonnelles en santé mentale: travail de Bachelor

Notre travail s’inscrit dans le cadre de l’obtention du diplôme de Bachelor en soins infirmiers.Deux études de cas sont présentées, concernant des personnes qui vivent des difficultés prenant forment dans la dynamique de leurs relations interpersonnelles et sociales. Des modèles théoriques infirmiers (King, Travelbee, Peplau, Watson) centrés sur la relation sont présentés en référence à la connaissance infirmière spécifique ainsi que l’art de la pratique congruente avec ces modèles conceptuels théoriques

Digging deeper into lymphatic vessel formation in vitro and in vivo

Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection. Lymphatic vasculature displays distinctive features than blood vasculature, and mechanisms underlying the formation of new lymphatic vessels during physiological and pathological processes are still poorly documented. Most studies on lymphatic vessel formation are focused on organism development rather than lymphangiogenic events occurring in adults. We have here studied lymphatic vessel formation in two in vivo models of pathological lymphangiogenesis (corneal assay and lymphangioma). These data have been confronted to those generated in the recently set up in vitro model of lymphatic ring assay. Ultrastructural analyses through Transmission Electron Microscopy (TEM) were performed to investigate tube morphogenesis, an important differentiating process observed during endothelial cell organization into capillary structures

Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

BACKGROUND Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations. OBJECTIVES This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD. METHODS Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. ClinicalTrials.gov: NCT01908283. RESULTS Among the 306 adults assessed (median age 42.7 years old, 70% with Crohn's disease, 78% receiving immunosuppressive treatment), only 33% had an immunization record available. Absence of seroprotection against tetanus (6%) was associated with increasing age and absence of booster dose; absence of seroprotection against varicella (1%) or measles (3%) was exclusively observed in younger patients with Crohn's disease. There was no statistically significant difference in immunoglobulin concentrations among treatment groups. Although vaccinations are strongly recommended in IBD patients, the frequencies of participants with at least 1 dose of vaccine recorded were low for nearly all antigens: tetanus 94%, diphtheria 87%, pertussis 54%, poliovirus 22%, measles-mumps-rubella 47%, varicella-zoster 0%, Streptococcus pneumoniae 5%, Neisseria meningitidis 12%, hepatitis A 41%, hepatitis B 48%, human papillomavirus 5%, and tick-borne encephalitis 6%. CONCLUSIONS Although many guidelines recommend the vaccination of IBD patients, disease prevention through immunization is still often overlooked, including in Switzerland, increasing their risk of vaccine-preventable diseases. Serological testing should be standardized to monitor patients' protection during follow-up as immunity may wane faster in this population

Senegal: Presidential elections 2019 - The shining example of democratic transition immersed in muddy power-politics

Whereas Senegal has long been sold as a showcase of democracy in Africa, including peaceful political alternance, things apparently changed fundamentally with the Senegalese presidentials of 2019 that brought new configurations. One of the major issues was political transhumance that has been elevated to the rank of religion in defiance of morality. It threatened political stability and peace. In response, social networks of predominantly young activists, created in 2011 in the aftermath of the Arab Spring focused on grass-roots advocacy with the electorate on good governance and democracy. They proposed a break with a political system that they consider as neo-colonialist. Moreover, Senegal’s justice is frequently accused to be biased, and the servility of the Constitutional Council which is in the first place an electoral court has often been denounced

Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, we explored the pleiotropy of these 25 loci. Finally, in a subset of individuals with epilepsy and detailed clinical data available, we performed phenome-wide association analyses between individual CNVs and clinical annotations categorized through the Human Phenotype Ontology (HPO). For six CNVs, we identified 19 significant associations with specific HPO terms and generated, for all CNVs, phenotype signatures across 17 clinical categories relevant for epileptologists. This is the most comprehensive investigation of CNVs in epilepsy and related seizure disorders, with potential implications for clinical practice

Primary angiosarcoma of the breast: a case-report of a 16 years old patient

No abstract availabl

Hypnosis sedation can reduce inflammatory reaction associated with oncologic breast surgery, as measured by NLR (neutrophil- to-lymphocytes ratio)

No Abstract availabl

Evaluation de l’augmentation de la radicalité chirurgicale sur la survie sans récidive dans le cadre des néoplasie ovariennes avancées

No abstract availabl

Diagnostic et suivi de l'infection par le VIH-1 (groupe M) (évaluation du support buvard pour la réalisation des techniques sérologiques et de biologie moléculaire)

Malgré d'importants progrès réalisés dans l'accès au traitement antirétroviral dans les pays à ressources limitées, l'absence de mesure périodique de charge virale empêche une prise en charge optimisée. Le support buvard (DBS) apparaît comme une alternative au plasma pour le diagnostic de l'infection et le suivi sous traitement des patients. Dans une étude prospective menée chez 59 patients infectés par le VIH-1, nous avons évalué ce support pour les tests de dépistage, la quantification de l'ARN, la détection de l'ADN proviral et les génotypiques de résistance aux antirétroviraux. Les résultats obtenus sont satisfaisants mais confirment la moindre sensibilité du support DBS en cas de faibles charges virales. L'optimisation des protocoles opératoires semble nécessaire mais l'utilisation des DBS pour les pays du Sud reste une option prometteuse.Despite important progress in access to antiretroviral therapy in resource-limited countries, the lack of periodic viral load measurements prevents an optimised monitoring. Dried blood spots (DBS) could serve as an interesting alternative to plasma for infection diagnosis and treatment monitoring. In a prospective study in 59 patients infected with HIV-1, we evaluated DBS for screening tests, RNA quantification, detection of proviral DNA and PCR amplification for drug resistance testing. The results are satisfying but confirm the lower sensitivity of DBS in low loads. The optimization of operating protocols seems necessary but the use of DBS for the South remains a promising option.LYON1-BU Santé (693882101) / SudocRENNES1-BU Santé (352382103) / SudocSudocFranceF