A Machine Learning Classification Framework for Early Prediction of Alzheimer’s Disease

People today, in addition to their concerns about getting old and having to go through watching themselves grow weak and wrinkly, are facing an increasing fear of dementia. There are around 47 million people affected by dementia worldwide and the cost associated with providing them health and social care support is estimated to reach 2 trillion by 2030 which is almost equivalent to the 18th largest economy in the world. The most common form of dementia with the highest costs in health and social care is Alzheimer’s disease, which gradually kills neurons and causes patients to lose loving memories, the ability to recognise family members, childhood memories, and even the ability to follow simple instructions. Alzheimer’s disease is irreversible, unstoppable and has no known cure. Besides being a calamity to affected patients, it is a great financial burden on health providers. Health care providers also face a challenge in diagnosing the disease as current methods used to diagnose Alzheimer’s disease rely on manual evaluations of a patient’s medical history and mental examinations such as the Mini-Mental State Examination. These diagnostic methods often give a false diagnosis and were designed to identify Alzheimer’s after stage two when the part of all symptoms are evident. The problem is that clinicians are unable to stop or control the progress of Alzheimer’s disease, because of a lack of knowledge on the patterns that triggered the development of the disease. In this thesis, we explored and investigated Alzheimer’s disease from a computational perspective to uncover different risk factors and present a strategic framework called Early Prediction of Alzheimer’s Disease Framework (EPADf) that would give a future prediction of early-onset Alzheimer’s disease. Following extensive background research that resulted in the formalisation of the framework concept, prediction approaches, and the concept of ranking the risk factors based on clinical instinct, knowledge and experience using mathematical reasoning, we carried out experiments to get further insight and investigate the disease further using machine learning models. In this study, we used machine learning models and conducted two classification experiments for early prediction of Alzheimer’s disease, and one ranking experiment to rank its risk factors by importance. Besides these experiments, we also presented two logical approaches to search for patterns in an Alzheimer’s dataset, and a ranking algorithm to rank Alzheimer’s disease risk factors based on clinical evaluation. For the classification experiments we used five different Machine Learning models; Random Forest (RF), Random Oracle Model (ROM), a hybrid model combined of Levenberg-Marquardt neural network and Random Forest, combined using Fischer discriminate analysis (H2), Linear Neural Networks (LNN), and Multi-layer Perceptron Model (MLP). These models were deployed on a de-identified multivariable patient’s data, provided by the ADNI (Alzheimer’s disease Neuroimaging Initiative), to illustrate the effective use of data analysis to investigate Alzheimer’s disease biological and behavioural risk factors. We found that the continues enhancement of patient’s data and the use of combined machine learning models can provide an early cost-effective prediction of Alzheimer’s disease, and help in extracting insightful information on the risk factors of the disease. Based on this work and findings we have developed the strategic framework (EPADf) which is discussed in more depth in this thesis

Environmental Impacts of the liquid waste from Assalaya Sugar Factory in Rabek Locality, White Nile State, Sudan

The study aimed to assess the environmental health impacts of the liquid waste from Assalaya Sugar Factory, the efficiency of the existing Assalaya effluent treatment plant, the dilution factors available in the White Nile to gather with wastewater environmental impacts. A descriptive cross-sectional focused on the Factory and its neighborhoods. Four hundred and thirty two out of 3931 households were statistically determined as the sample size, the individual samples were picked using multi-stage stratified method 432 households selected as sample size. Data were collected by using structured questionnaires, field observations, laboratory analysis and interviewing the concerned and affected persons. The effluent load discharged from the factory into the Al - jassir canal at the White Nile was analyzed for BOD, COD, pH, PO4, TDS, TSS, Turbidity, Color, and flow rate.The Data were processed by using the Statistical Package for Social Science (SPSS) version 16, Chi-square test, test associations and office excel 2007. The study showed that Eighty one percent of the households used the surplus irrigation canal as a source for water supply. 64% of the respondents suffered from diarrhea, vomiting and allergic diseases, the rather low rate of water consumption and the bad quality of water consumed were reflected adversely on hygiene and consequently increased water related diseases. The study concludes that always or sometime 49.5% of the water collectors were children and used animals and plastic containers for water collection and transportation. The conducted laboratory water analysis revealed that the average concentrations of PO4, COD and BOD of the raw wastewater produced by Assalaya Sugar Factory were 4260, 3800 and 1500 mg/l, respectively, these values were above the WHO recommended concentrations for the disposed treated effluent (2, 250 and 30 mg/L respectively). As to physical analysis; the turbidity on the average was higher (540 NTU) and the color was (854 TCU) also high

Sign Language Recognition using Deep Learning

Sign Language Recognition is a form of action recognition problem. The purpose of such a system is to automatically translate sign words from one language to another. While much work has been done in the SLR domain, it is a broad area of study and numerous areas still need research attention. The work that we present in this paper aims to investigate the suitability of deep learning approaches in recognizing and classifying words from video frames in different sign languages. We consider three sign languages, namely Indian Sign Language, American Sign Language, and Turkish Sign Language. Our methodology employs five different deep learning models with increasing complexities. They are a shallow four-layer Convolutional Neural Network, a basic VGG16 model, a VGG16 model with Attention Mechanism, a VGG16 model with Transformer Encoder and Gated Recurrent Units-based Decoder, and an Inflated 3D model with the same. We trained and tested the models to recognize and classify words from videos in three different sign language datasets. From our experiment, we found that the performance of the models relates quite closely to the model's complexity with the Inflated 3D model performing the best. Furthermore, we also found that all models find it more difficult to recognize words in the American Sign Language dataset than the others

A SIMPLE METHOD FOR DETERMINATION AND CHARACTERIZATION OF IMIDAZOLINONE HERBICIDE (IMAZAPYR/IMAZAPIC) RESIDUES IN CLEARFIELD® RICE SOIL

A study was conducted to evaluate residues of imidazolinone (IMI) in soil. Samples were taken from three Clearfield® rice fields as IMI which have been used for six years. IMI herbicides (imazapic/imazapyr) were widely used in Clearfield® rice soils. To date, few studies are available on the residues of these herbicides, especially in the context of Malaysian soil. Therefore, for this purpose, high performance liquid chromatography (HPLC) with UV detection was performed using a Zorbax stable bond C18 (4.6× 250 mm, 5 µm) column, with two mobile phases. The average percentage recovery for imazapyr and imazapic varied from 76%-107% and 71-77%, with 0.1-5 µg/ml fortification level, respectively. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.05 and 4.09 for imazapic and 0.171 and 0.511 µg/ml for imazapyr respectively, in the top 15 cm. In the extracted soil sample, it was 0.19 µg/ml for imazapic and 0.04 µg/ml for imazapyr, respectively. Based on this study, a pre-harvest period of 40-60 day is suggested for rice crops after IMI application

Abstract Pattern Image Generation using Generative Adversarial Networks

Abstract pattern is very commonly used in the textile and fashion industry. Pattern design is an area where designers need to come up with new and attractive patterns every day. It is very difficult to find employees with a sufficient creative mindset and the necessary skills to come up with new unseen attractive designs. Therefore, it would be ideal to identify a process that would allow for these patterns to be generated on their own with little to no human interaction. This can be achieved using deep learning models and techniques. One of the most recent and promising tools to solve this type of problem is Generative Adversarial Networks (GANs). In this paper, we investigate the suitability of GAN in producing abstract patterns. We achieve this by generating abstract design patterns using the two most popular GANs, namely Deep Convolutional GAN and Wasserstein GAN. By identifying the best-performing model after training using hyperparameter optimization and generating some output patterns we show that Wasserstein GAN is superior to Deep Convolutional GAN

Abstract Pattern Image Generation using Generative Adversarial Networks

Abstract pattern is very commonly used in the textile and fashion industry. Pattern design is an area where designers need to come up with new and attractive patterns every day. It is very difficult to find employees with a sufficient creative mindset and the necessary skills to come up with new unseen attractive designs. Therefore, it would be ideal to identify a process that would allow for these patterns to be generated on their own with little to no human interaction. This can be achieved using deep learning models and techniques. One of the most recent and promising tools to solve this type of problem is Generative Adversarial Networks (GANs). In this paper, we investigate the suitability of GAN in producing abstract patterns. We achieve this by generating abstract design patterns using the two most popular GANs, namely Deep Convolutional GAN and Wasserstein GAN. By identifying the best-performing model after training using hyperparameter optimization and generating some output patterns we show that Wasserstein GAN is superior to Deep Convolutional GAN

FUSING OF OPTICAL AND SYNTHETIC APERTURE RADAR (SAR) REMOTE SENSING DATA: A SYSTEMATIC LITERATURE REVIEW (SLR)

Remote sensing and image fusion have recognized many important improvements throughout the recent years, especially fusion of optical and synthetic aperture radar (SAR), there are so many published papers that worked on fusing optical and SAR data which used in many application fields in remote sensing such as Land use Mapping and monitoring. The goal of this survey paper is to summarize and synthesize the published articles from 2013 to 2018 which focused on the fusion of Optical and synthetic aperture radar (SAR) remote sensing data in a systematic literature review (SLR), based on the pre-published articles on indexed database related to this subject and outlining the latest techniques as well as the most used methods. In addition this paper highlights the most popular image fusion methods in this blending type. After conducting many researches in the indexed databases by using different key words related to the topic “fusion Optical and SAR in remote sensing”, among 705 articles, chosen 83 articles, which match our inclusion criteria and research questions as results ,all the systematic study ‘ questions have been answered and discussed

Semantic Segmentation and Depth Estimation of Urban Road Scene Images Using Multi-Task Networks

In autonomous driving, environment perception is an important step in understanding the driving scene. Objects in images captured through a vehicle camera can be detected and classified using semantic segmentation and depth estimation methods. Both these tasks are closely related to each other and this association helps in building a multi-Task neural network where a single network is used to generate both views from a given monocular image. This approach gives the flexibility to include multiple related tasks in a single network. It helps reduce multiple independent networks and improve the performance of all related tasks. The main aim of our research presented in this paper is to build a multi-Task deep learning network for simultaneous semantic segmentation and depth estimation from monocular images. Two decoder-focused U-N et-based multi-Task networks that use a pre-Trained Resnet-50 and DenseNet-121 which shared encoder and task-specific decoder networks with Attention Mechanisms are considered. We also employed multi-Task optimization strategies such as equal weighting and dynamic weight averaging during the training of the models. The corresponding models' performance is evaluated using mean IoU for semantic segmentation and Root Mean Square Error for depth estimation. From our experiments, we found that the performance of these multi-Task networks is on par with the corresponding single-Task networks

Brain Tumor Segmentation in Fluid-Attenuated Inversion Recovery Brain MRI using Residual Network Deep Learning Architectures

Early and accurate detection of brain tumors is very important to save the patient's life. Brain tumors are generally diagnosed manually by a radiologist by analyzing the patient's brain MRI scans which is a time-consuming process. This led to our study of this research area for finding out a solution to automate the diagnosis to increase its speed and accuracy. In this study, we investigate the use of Residual Network deep learning architecture to diagnose and segment brain tumors. We proposed a two-step method involving a tumor detection stage, using ResNet50 architecture, and a tumor area segmentation stage using ResU-Net architecture. We adopt transfer learning on pre-trained models to help get the best performance out of the approach, as well as data augmentation to lessen the effect of data population imbalance and hyperparameter optimization to get the best set of training parameter values. Using a publicly available dataset as a testbed we show that our approach achieves 84.3 % performance outperforming the state-of-the-art using U-Net by 2% using the Dice Coefficient metric

Data Augmentation Using Generative Adversarial Networks to Reduce Data Imbalance with Application in Car Damage Detection

Automatic car damage detection and assessment are very useful in alleviating the burden of manual inspection associated with car insurance claims. This will help filter out any frivolous claims that can take up time and money to process. This problem falls into the image classification category and there has been significant progress in this field using deep learning. However, deep learning models require a large number of images for training and oftentimes this is hampered because of the lack of datasets of suitable images. This research investigates data augmentation techniques using Generative Adversarial Networks to increase the size and improve the class balance of a dataset used for training deep learning models for car damage detection and classification. We compare the performance of such an approach with one that uses a conventional data augmentation technique and with another that does not use any data augmentation. Our experiment shows that this approach has a significant improvement compared to another that does not use data augmentation and has a slight improvement compared to one that uses conventional data augmentation