Influence of HIV and other risk factors on tuberculosis

Background. Tuberculosis (TB) notification in South Africa has increased six-fold over the past two decades, mainly because of the HIV epidemic.Objectives. To describe the sociodemographic and outcome characteristics of TB patients, and to identify risk factors associated with TB treatment outcomes stratified by HIV status.Methods. A cross-sectional study was used to analyse data from the Cape Town Metro East geographical service area (GSA) electronic TB register (ETR.Net), including adult patients aged ≥15 years who initiated TB treatment between 1 July 2011 and 30 June 2012.Results. TB case notification in the GSA was 922 per 100 000 population. Of the 12 672 TB patients registered, 50.5% were co-infected with HIV. The death rate in co-infected patients was 5.4% v. 2.8% in HIV-negative patients, the rate of treatment success 66.6% v. 73.5%, and the rate of unfavourable treatment outcome 28.1% v. 23.7%. The Khayelitsha subdistrict had the highest proportion of TB burden (37.0%) and co-infection (47.6%). Fourteen percent of patients had extrapulmonary TB, 65.9% of whom were co-infected with HIV. In the multivariate analysis, HIV infection (relative risk (RR) 1.2), retreatment (RR 1.4) and sputum smear microscopy not done (RR 1.4) were significantly associated with unfavourable treatment outcome. The Eastern (RR 0.9) and Northern (RR 0.7) subdistricts were less likely to have unfavourable outcomes compared with Khayelitsha. In the stratified analysis, retreatment and smear not done were significant risk factors for an unfavourable treatment outcome in both co-infected and HIV-negative patients.Conclusions. The burdens of both TB and co-infection were high in this community, although HIV prevalence varied. Mortality was higher and treatment completion lower in co-infected patients than in those who were HIV-negative. Co-infection, previous TB treatment and smear not done were significant risk factors for an unfavourable outcome in all patients

Groundwater study of the Piawaning townsite

A groundwater study was carried out in and around the townsite of Piawaning. It aimed to accelerate the implementation of effective salinity management options. The study consisted of a drilling investigation, expansion of a piezometer network, a pumping test and a flood risk analysis

Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster

The discovery of life extension in Caenorhabditis elegans treated with anticonvulsant medications has raised the question whether these drugs are prospective anti-aging candidate compounds. The impact of these compounds on neural modulation suggests that they might influence the chronic diseases of aging as well. Lamotrigine is a commonly used anticonvulsant with a relatively good adverse-effects profile. In this study, we evaluated the interaction between the impacts of lamotrigine on mortality rate, lifespan, metabolic rate and locomotion. It has been proposed in a wide range of animal models that there is an inverse relationship between longevity, metabolic rate, and locomotion. We hypothesized that the survival benefits displayed by this compound would be associated with deleterious effects on health span, such as depression of locomotion. Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in locomotor activity and a trend towards metabolic rate depression. Our findings underscore the view that assessing health span is critical in the pursuit of useful anti-aging compounds

Systematic Topological Assessment of Power System for Restoration Process Based on the Fractal Dimension

Despite the extensive studies that have been done regarding the restoration problems and issues of power systems, the impact of the topological extent of the power grid structure on power system restoration has not been analyzed or assessed. This objective, which is neglected in the process of planning and development of transmission systems, could make operators encounter more challenges during the restoration process and prolongation of the restoration procedures. In this study, an attempt is made to evaluate the desirability of a power system network structure according to the main requirement of the restoration process, i.e. restoration time. To address this concern, a systematic approach on the basis of a fractal-based quantitative index is introduced to measure the topological extent of a power system network as a representative of restoration time. The proposed approach combines the feeding point condition, topological extent, and support routes to deliver an index associated with the time and success probability of the power system restoration process

Low-Cost Aquifer Storage and Recovery: Implications for Improving Drinking Water Access for Rural Communities in Coastal Bangladesh

Fresh water resources are scarce in rural communities in the southern deltaic plains of Bangladesh where both shallow and deep groundwater is frequently brackish, and fresh water ponds have been increasingly salinized by inundation during storm surges and brackish-water aquaculture. Low-cost aquifer storage and recovery (ASR) schemes were constructed at 13 villages in three coastal districts by developing storage in shallow confined fine to medium sand aquifers overlain by variable thicknesses of silt and clay. A typical ASR scheme consisted of a double-chambered graded sand filtration tank with a volume of 19.5  m3 that feeds filtered pond water to four to six large diameter (d=30.5 or 56 cm) infiltration wells through PVC pipes fitted with stop valves and flow meters. The infiltration wells were completed at 18–31 m below ground and filled with well-sorted gravel capped with a thin layer of fine sand that acts as a second stage filter. Infiltration rates at 13 sites averaged 3  m3/day (range: 3–6  m3/day) over one year of operation. At 11 sites where water was abstracted, the recovery rate ranged from 5 to 40%. The source pond source water frequently had turbidity values of ≥100  NTU. After sand filtration, the turbidity is typically 5 NTU. Despite this, clogging management involving frequent (monthly to weekly) manual washing to remove fine materials deposited in the sand filtration tank and the infiltration wells is found to be necessary and effective, with post-manual-washing operational infiltration rates restored to annual average values. E. coli counts in recovered water are greatly reduced compared to raw pond water, although E. coli is still detected in about half of the samples. Arsenic in recovered water was detected to be at level of > 100  μg/L repeatedly at three sites, suggesting that As risks must be carefully managed and require further investigation

Groundwater study of the Bencubbin townsite

A groundwater study of the townsite of Bencubbin. It aimed to accelerate the implementation of effective salinity management options. The study consisted of drilling investation and installation of a piezometer network, groundwater flow modelling and a flood risk analysis

Groundwater study of the Pingrup townsite

A groundwater study was carried out in the townsite of Pingrup. It aimed to accelerate the implementation of effective salinity risk management. The study consisted of a drilling investigation and expansion of a piezometer network, a pumping test, groundwater flow modelling and a flood risk analysis

Low Resistance Polycrystalline Diamond Thin Films Deposited by Hot Filament Chemical Vapour Deposition

Polycrystalline diamond thin films with outgrowing diamond (OGD) grains were deposited onto silicon wafers using a hydrocarbon gas (CH4) highly diluted with H2 at low pressure in a hot filament chemical vapour deposition (HFCVD) reactor with a range of gas flow rates. X-ray diffraction (XRD) and SEM showed polycrystalline diamond structure with a random orientation. Polycrystalline diamond films with various textures were grown and (111) facets were dominant with sharp grain boundaries. Outgrowth was observed in flowerish character at high gas flow rates. Isolated single crystals with little openings appeared at various stages at low gas flow rates. Thus, changing gas flow rates had a beneficial influence on the grain size, growth rate and electrical resistivity. CVD diamond films gave an excellent performance for medium film thickness with relatively low electrical resistivity and making them potentially useful in many industrial applications