Chilean Spanish transcultural adaptation of CAP-II and SIR scales in an online format for parents of children with hearing aids or cochlear implants

Spoken language acquisition is challenging for very young deaf or hard-of-hearing children (DHH) who wear hearing aids or cochlear implants (CI). Timely decision-making for treatment is essential for these children and requires suitable assessments. Two such assessments are the Categories of Auditory Performance Index II (CAP-II) and the Speech Intelligibility Rating Scale (SIR). These have been shown to be helpful for the ongoing evaluation of developing speech perception and spoken language skills in various languages, but they are not available in Chilean Spanish. This study aimed to create a Chilean Spanish translation of the CAP-II and SIR appropriate for online self-administration by parents-caregivers in Chile to assist professionals in monitoring DHH children’s progress, considering the COVID-19 restrictions. The methods used in the process started with translating a self-report proposal from the original English versions of the CAP-II and SIR scales. Finally, the Chilean Spanish versions were tested in 107 Chilean parents-caregivers of DHH children with CIs. The results suggest these instruments are suitable for use in a Chilean context

Electrocardiographic markers of structural heart disease and predictors of death in 2332 unselected patients undergoing outpatient Holter recording

To test the hypothesis that the QS interval of ventricular ectopic beats (VEBs) (ventricular ectopic QS interval, VEQSI) would provide a marker for the presence of structural heart disease and a predictor of mortality

Scenario Based Methodologies in Identifying Ubicomp Application Sets

In ubiquitous systems of the future, a requirement for appropriate methods for the selection, analysis and evaluation of applications is evident. Traditional methods of analysis rely heavilyon the inherent predictability of the system, something which is totally lacking in ubiquitous systems. This paper discusses one possible approach to flexible analysis and evaluation, the ScenarioBased Approach, describing its use in the IST FP6 project, Daidalos. The Scenario Based approach addresses the adaptive nature of ubiquitous systems by its own intrinsic flexibility. This paper explains the approach and argues that it is appropriate that a method of analysis should exhibit similar characteristics to the object of that analysis

Learning intrinsic excitability in medium spiny neurons

We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way. We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parametrization of individual ion channels on the neuronal activation function. We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions. We emphasize that the effects of intrinsic neuronal variability on spiking behavior require a distributed mode of synaptic input and can be eliminated by strongly correlated input. We show how variability and adaptivity in ion channel conductances can be utilized to store patterns without an additional contribution by synaptic plasticity (SP). The adaptation of the spike response may result in either "positive" or "negative" pattern learning. However, read-out of stored information depends on a distributed pattern of synaptic activity to let intrinsic variability determine spike response. We briefly discuss the implications of this conditional memory on learning and addiction.Comment: 20 pages, 8 figure

Heterobimetallic ruthenium–zinc complexes with bulky N-heterocyclic carbenes: syntheses, structures and reactivity

The ruthenium–zinc heterobimetallic complexes, [Ru(IPr)2(CO)ZnMe][BArF4] (7), [Ru(IBiox6)2(CO)(THF) ZnMe][BArF4] (12) and [Ru(IMes)’(PPh3)(CO)ZnMe] (15), have been prepared by reaction of ZnMe2 with the ruthenium N-heterocyclic carbene complexes [Ru(IPr)2(CO)H][BArF4] (1), [Ru(IBiox6)2(CO)(THF)H][BArF4] (11) and [Ru(IMes)(PPh3)(CO)HCl] respectively. 7 shows clean reactivity towards H2, yielding [Ru(IPr)2(CO) (¿2-H2)(H)2ZnMe][BArF4] (8), which undergoes loss of the coordinated dihydrogen ligand upon application of vacuum to form [Ru(IPr)2(CO)(H)2ZnMe][BArF4] (9). In contrast, addition of H2 to 12 gave only a mixture of products. The tetramethyl IBiox complex [Ru(IBioxMe4)2(CO)(THF)H][BArF4] (14) failed to give any isol- able Ru–Zn containing species upon reaction with ZnMe2. The cyclometallated NHC complex [Ru(IMes)’ (PPh3)(CO)ZnMe] (15) added H2 across the Ru–Zn bond both in solution and in the solid-state to afford [Ru(IMes)’(PPh3)(CO)(H)2ZnMe] (17), with retention of the cyclometallati

A mild, copper-catalysed amide deprotection strategy:use of tert-butyl as a protecting group

AbstractMild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection

Highest weight Macdonald and Jack Polynomials

Fractional quantum Hall states of particles in the lowest Landau levels are described by multivariate polynomials. The incompressible liquid states when described on a sphere are fully invariant under the rotation group. Excited quasiparticle/quasihole states are member of multiplets under the rotation group and generically there is a nontrivial highest weight member of the multiplet from which all states can be constructed. Some of the trial states proposed in the literature belong to classical families of symmetric polynomials. In this paper we study Macdonald and Jack polynomials that are highest weight states. For Macdonald polynomials it is a (q,t)-deformation of the raising angular momentum operator that defines the highest weight condition. By specialization of the parameters we obtain a classification of the highest weight Jack polynomials. Our results are valid in the case of staircase and rectangular partition indexing the polynomials.Comment: 17 pages, published versio

Copper malonamide complexes and their use in azide-alkyne cycloaddition reactions

A series of copper(i) malonamide complexes have been synthesised and their catalytic activity explored in 1,3-dipolar cycloaddition reactions: the first time this ligand motif has been reported in a catalytic transformation.</p