The role of dietary nucleotide on energy sources and growth function of common carp, Cyprinus carpio

Considering the effects of dietary nucleotides on growth and metabolism, this study was conducted to determine the effect of different levels of this nutrient on the sources of the body needed energy, and growth performance of common carp. Fish with average (±SD) weight of 7.5±0.2g were fed to five levels of dietary nucleotides containing 0, 0.1, 0.2, 0.3 and 0.4 percent for 8 weeks. Fish were fed 5 times daily according the satiation. After 56 days, the results showed that the level 0.2% nucleotide had the highest growth rate in terms of weight and length, but other parameters such as body weight, specific growth rate and feed conversion ratio, differences were not significantly changed. Biochemical analysis of serum parameters and proximate analysis showed that the physiological function of fish affected by different levels of nucleotides whereas in the energy supply sources, including glucose, triacyleglycerol, total protein and albumin there were no significant difference in cholesterol and lipid content of carcass. This study conveys a positive effect on the biosynthesis of dietary nucleotides on energy sources and growth functions, while the common carp has ability to synthesize this substance into the body, the level of 0.2% in the diet can affection *Corresponding author sufficient effect on growth and some biochemical indices

Genetic programming for brick's chemical analysis modelling

This study is part of the search for a sediment management methodology and the basic material that is designed for the manufacture of fired brick, in which we tackle the problem of choosing the mud samples from dredging the Algerian dams in particular (Bouhanifia dam western Algeria) and the choice of clay that comes from different deposits. We propose an approach for sampling using a computer optimization model that allows solving and optimizing a characterization to retain the best adapted sample (chemically) using the genetic algorithm.Keywords: Sludge- Dredging- Sample- Chemical Characterization- Brick-Optimization Methods- Genetic Algorithm

Effects of different levels of dietary nucleotide on growth performance, survival and liver enzyme activity of Caspian salmon (Salmo trutta caspius Kessler, 1877) juveniles

Caspian salmon (Salmo trutta caspius) juveniles were fed with dietary nucleotide levels of 0, 0.15, 0.25, 0.35 and 0.5% to investigate their effects on growth performance, survival rate and liver enzymes. Juveniles with an initial average weight of 12.26±0.001g were fed with the experimental diets for 60 days. The trial was carried out in 300 liter tanks each containing 35 fish which were fed with five meals a day at the rate of 34•5% of body weight. Statistical analysis was performed using One-way ANOVA. Results of the study showed that the addition of dietary nucleotide led to significant increase of body weight gain (BW), weight increase percentage (BWI), specific growth rate (SGR), protein efficiency ratio (PER), protein productive value (PPV) and feed intake but significant decrease of food conversion ratio (FCR) as compared to the control treatment (P0.05). The best value of growth improvement indices was observed at the dietary level of 0.25% nucleotide. Liver enzymes including AST, ALT and LDH at the level of 0.35% and ALP at the level of 0.25% were significantly lower than control treatment (P<0.05). Our results also indicated that dietary nucleotide can have positive effects on growth performance and would decrease liver demolition

Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T helper 17 cells and related cytokines in systemic lupus erythematosus

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. Objective: To investigate the effect of 1,25VitD3 on Th17 cells and on the expression of related cytokines in SLE patients. Method: Thirty SLE patients (newly diagnosed or in remission) were sampled for 10 ml whole blood to isolate peripheral blood mononuclear cells (PBMCs) using Ficoll-Hypaque density gradient centrifugation. Isolated cells were cultured in the presence and absence of 50 nM 1,25VitD3. After incubation, cells were harvested and stimulated for 4-5 hours with phorbol myristate acetate (PMA) and ionomycin in the presence of brefeldin A. IL-17 secreting cells were analyzed by flowcytometry. RNA was extracted from cultured cells, cDNA was synthesized, and the expression levels of IL-6, IL-17, IL-23 and TGF-β genes were assessed by real-time PCR. Results: The percentage of Th17 cells (CD3+CD8- IL-17+ T cells) decreased significantly in 1,25VitD3-treated cells (3.67 ± 2.43%) compared to untreated cells (4.65 ± 2.75%) (p=0.003). The expression of TGF-β up regulated (1.38-fold) and the expression of IL-6 (50%), IL-17 (27%) and IL-23 (64%) down regulated after 1,25VitD3 treatment. Conclusion: This study showed that 1,25VitD3 modulates Th17 related pathways in SLE patients and revealed the immunomodulatory effect of 1,25VitD3 on the Th17 mediated autoimmunity. © 2015, Shiraz University of Medical Sciences. All rights reserved

Kaluza–Klein gluon + jets associated production at the Large Hadron Collider

AbstractThe Kaluza–Klein excitations of gluons offer the exciting possibility of probing bulk Randall–Sundrum (RS) models. In these bulk models either a custodial symmetry or a deformation of the metric away from AdS is invoked in order to deal with electroweak precision tests. Addressing both these models, we suggest a new channel in which to study the production of KK-gluons (gKK): one where it is produced in association with one or more hard jets. The cross-section for the gKK + jets channel is significant because of several contributing sub-processes. In particular, the 1-jet and the 2-jet associated processes are important because at these orders in QCD the qg and the gg initial states respectively come into play. We have performed a hadron-level simulation of the signal and present strategies to effectively extract the signal from what could potentially be a huge background. We present results for the kinematic reach of the LHC Run-II for different gKK masses in bulk-RS models

Comparing Perceived Social Support and Perceived Stress in Healthy Pregnant Women and Pregnant Women with Preeclampsia

BACKGROUND: Preeclampsia is a prevalent side effect of pregnancy. Different studies have reported different results about the relationship between mental stress and blood pressure disorders. In addition, social support is highly important to help women who experience risky pregnancy in adapting to the stressors they experience. This study aimed to compare perceived social support and perceived stress in women with and without preeclampsia.METHODS AND MATERIALS: Fifty pregnant women definitely diagnosed with preeclampsia and 50 healthy pregnant women visiting public hospitals including Hazrat Masoumeh, Motazedi,and Imam Reza in Kermanshah-Iran took part in a descriptiveanalytical study from June 2017 to January 2018. Data gathering tools included demographics questionnaire, social support appraisals scale and perceived stress scale. The collected data was analyzed with SPSS (v.20) using independent t-test.RESULTS: The mean score of perceived social support in the preeclampsia and non-preeclampsia groups were 69.88±7.3 and 76.80±7.6 respectively (P&lt;0.01). The mean score of perceived stress in the preeclampsia and non-preeclampsia groups were 35.6±8.7 and 26.01±5.56 respectively (P&lt;0.01). This means that compared with healthy women, women with preeclampsia perceived more stress and less social support.CONCLUSION: In comparison with healthy pregnant women, women with preeclampsia perceived more stress and less social support. Healthcare providers should recommended to pay more attention to improving social support and attenuating stress inpregnant women

Group velocity control in the ultraviolet domain via interacting dark-state resonances

The propagation of a weak probe field in a laser-driven four-level atomic system is investigated. We choose mercury as our model system, where the probe transition is in the ultraviolet region. A high-resolution peak appears in the optical spectra due to the presence of interacting dark resonances. We show that this narrow peak leads to superluminal light propagation with strong absorption, and thus by itself is only of limited interest. But if in addition a weak incoherent pump field is applied to the probe transition, then the peak structure can be changed such that both sub- and superluminal light propagation or a negative group velocity can be achieved without absorption, controlled by the incoherent pumping strength

Hydrodynamic instabilities in gaseous detonations: comparison of Euler, Navier–Stokes, and large-eddy simulation

A large-eddy simulation is conducted to investigate the transient structure of an unstable detonation wave in two dimensions and the evolution of intrinsic hydrodynamic instabilities. The dependency of the detonation structure on the grid resolution is investigated, and the structures obtained by large-eddy simulation are compared with the predictions from solving the Euler and Navier–Stokes equations directly. The results indicate that to predict irregular detonation structures in agreement with experimental observations the vorticity generation and dissipation in small scale structures should be taken into account. Thus, large-eddy simulation with high grid resolution is required. In a low grid resolution scenario, in which numerical diffusion dominates, the structures obtained by solving the Euler or Navier–Stokes equations and large-eddy simulation are qualitatively similar. When high grid resolution is employed, the detonation structures obtained by solving the Euler or Navier–Stokes equations directly are roughly similar yet equally in disagreement with the experimental results. For high grid resolution, only the large-eddy simulation predicts detonation substructures correctly, a fact that is attributed to the increased dissipation provided by the subgrid scale model. Specific to the investigated configuration, major differences are observed in the occurrence of unreacted gas pockets in the high-resolution Euler and Navier–Stokes computations, which appear to be fully combusted when large-eddy simulation is employed

Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision”

Until now, the results of nanotoxicology research have shown that the interactions between nanoparticles (NPs) and cells are remarkably complex. In order to get a deep understanding of the NP-cell interactions, scientists have focused on the physicochemical effects. However, there are still considerable debates about the regulation of nanomaterials and the reported results are usually in contradictions. Here, we are going to introduce the potential key reasons for these conflicts. In this case, modification of conventional in vitro toxicity assays, is one of the crucial ignored matter in nanotoxicological sciences. More specifically, the conventional methods neglect important factors such as the sedimentation of NPs and absorption of proteins and other essential biomolecules onto the surface of NPs. Another ignored matter in nanotoxicological sciences is the effect of cell “vision” (i.e., cell type). In order to show the effects of these ignored subjects, we probed the effect of superparamagnetic iron oxide NPs (SPIONs), with various surface chemistries, on various cell lines. We found thatthe modification of conventional toxicity assays and the consideration of the “cell vision” concept are crucial matters to obtain reliable, and reproducible nanotoxicology data. These new concepts offer a suitable way to obtain a deep understanding on the cell-NP interactions. In addition, by consideration of these ignored factors, the conflict of future toxicological reports would be significantly decreased