A randomised-controlled trial investigating potential underlying mechanisms of a functionality-based approach to improving women’s body image

Focusing on body functionality is a promising technique for improving women's body image. This study replicates prior research in a large novel sample, tests longer-term follow-up effects, and investigates underlying mechanisms of these effects (body complexity and body-self integration). British women (N = 261) aged 18–30 who wanted to improve their body image were randomised to Expand Your Horizon (three online body functionality writing exercises) or an active control. Trait body image was assessed at Pretest, Posttest, 1-week, and 1-month Follow-Up. To explore whether changes in body complexity and body-self integration ‘buffer’ the impact of negative body-related experiences, participants also completed beauty-ideal media exposure. Relative to the control, intervention participants experienced improved appearance satisfaction, functionality satisfaction, body appreciation, and body complexity at Posttest, and at both Follow-Ups. Neither body complexity nor body-self integration mediated intervention effects. Media exposure decreased state body satisfaction among intervention and control participants, but neither body complexity nor body-self integration moderated these effects. The findings underscore the value of focusing on body functionality for improving body image and show that effects persist one month post-intervention

Adaptive Coding and Packet Rates for TCP-Friendly VoIP Flows

If low-rate VoIP is transmitted over congested links, both the coding and the packet rate need to be adapted to achieve the best conversational quality: On an Ethernet network it is better to jointly change packet rate and speech coding rate; in WLAN networks it is sufficient to change the packet rate. We also study whether TCP-friendly rate control algorithms are suitable for dynamically adapting packet and coding rate of a VoIP flow. Our results show that cannot be used for VoIP applications as they only control the packet rate do not consider packet sizes. Also, they do not transmit small (speech) packets fairly. We present an enhanced version of the TCP friendly rate control (TFRC) protocol that transmits small packets fairly and evaluate it with network simulations

Consistency support for a decentralized management in closed multiparty conferences using SIP

Distributed multimedia applications such as conference and collaborative applications require an appropriate conference management. Close group conferences like meetings, discussions, teleseminars, or consultations need a strictly controlled group membership. Current conference systems achieve this by using a centralized group server as specified in the H.32x standards. Decentralized approaches are scarcely used so far, although they are more flexible. They avoid infrastructure dependencies and single point of failure problems which are often encountered in group server approaches, e.g. in classical virtual private networks. A decentralized conference management requires a consistency support by the underlying communication service. The Session Initiation Protocol (SIP) has become a widely applied protocol to support the signaling of multimedia applications in the Internet. It is also applied to support multiparty conference applications. The great majority of these approaches is related to open group and centralized organized conferences. For closed decentralized managed conferences, no solutions have been proposed up to now. In this paper we present such a group communication service based on SIP that ensures the consistency of decentralized managed group data

CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion

Microglia are the resident macrophage population of the CNS and are considered its major immunocompetent elements. They are activated by any type of brain pathology and can migrate to the lesion site. The chemokine CXCL10 is expressed in neurons in response to brain injury and is a signaling candidate for activating microglia and directing them to the lesion site. We recently identified CXCR3, the corresponding receptor for CXCL10, in microglia and demonstrated that this receptor system controls microglial migration. We have now tested the impact of CXCR3 signaling on cellular responses after entorhinal cortex lesion. In wild-type mice, microglia migrate within the first 3 d after lesion into the zone of axonal degeneration, where 8 d after lesion denervated dendrites of interneurons are subsequently lost. In contrast, the recruitment of microglia was impaired in CXCR3 knock-out mice, and, strikingly, denervated distal dendrites were maintained in zones of axonal degeneration. No differences between wild-type and knock-out mice were observed after facial nerve axotomy, as a lesion model for assessing microglial proliferation. This shows that CXCR3 signaling is crucial in microglia recruitment but not proliferation, and this recruitment is an essential element for neuronal reorganization

Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion

Despite transient, myelin-directed adaptive immune responses in regions of fiber tract degeneration, none of the current models of fiber tract injuries evokes disseminated demyelination, implying effective mechanisms maintaining or re-establishing immune tolerance. In fact, we have recently detected CD95L upregulation accompanied by apoptosis of leukocytes in zones of axonal degeneration induced by entorhinal cortex lesion (ECL), a model of layer-specific axonal degeneration. Moreover, infiltrating monocytes readily transformed into ramified microglia exhibiting a phenotype of immature (CD86+/CD80-) antigen-presenting cells. We now report the appearance of the axonal antigen neurofilament-light along with increased T cell apoptosis and enhanced expression of the pro-apoptotic gene Bad in cervical lymph nodes after ECL. In order to test the functional significance of such local and systemic depletory/regulatory mechanisms on subsequent immunity to central nervous system antigens, experimental autoimmune encephalomyelitis was induced by proteolipid protein immunization 30 days after ECL. In three independent experiments, we found significantly diminished disease scores and infiltrates in lesioned compared to sham-operated SJL mice. This is consistent with a previous meta-statistical analysis (Goodin et al. in Neurology 52:1737-1745, 1999) rejecting the O-hypothesis that brain trauma causes or exacerbates multiple sclerosis. Conversely, brain injuries may involve long-term tolerogenic effects towards brain antigens