Evaluation of maternal and fetal outcome in corona positive pregnant women

Background: COVID-19 has spread globally at an accelerated rate with rapid increases in cases and mortality. Viral pneumonia is one of the leading causes of pregnancy deaths worldwide. Physiological changes during pregnancy, such as reduced functional residual volumes, diaphragm elevation, and oedema of respiratory tract mucosa, as well as changes in cell immunity can lead to increased susceptibility to viral infections and can have worsened outcomes.Methods: The study was conducted after clearance from Board of Studies and Ethical committee in the Department of obstetrics and gynaecology, Muzaffarnagar medical college, Muzaffarnagar. It was a retrospective study. Out of total 1500 covid positive patients admitted in 3 months, 33 pregnant women were included which were covid positive.Results: The study population consisted of 16 (48.5%) women from 20-25 years, 12 (36.4%) women from 26-30 years and 5 (15.2%) women from above 30 years. There was history of exposure among all (100.0%) pregnant women with only 2 (6.1%) having symptoms of COVID-19.Out of 33, 8 patients were severelyanemic, 4 had preeclampsia, 2 cases had previous 2 LSCS, 5 previous 1 LSCS, 1 leaking pervaginum, 3 cases had fetal distress at admission. As per gestational age, 9 (27.3%) women had pre-term delivery, 21 (63.6%) had normal term delivery and 3 (9.1%) had post-term delivery. 13 women were primigravida and 20 were multigravida. The mode of delivery was LSCS among 24 (73%) and normal delivery among 1 (3.0%) women.Conclusions: In our study, there were no maternal and fetal complications among pregnant women with COVID-19

Abortion and contraception practices in COVID-19 era

Background: To protect the gains made in sexual and reproductive health in over the past several decades, care for childbearing women and newborn infant’s needs to continue during the pandemic. The provision of safe abortion and contraceptive services remains critical. When staff and services are under extreme stress there is a real risk of increasing avoidable harm. Aim and objectives were to determine the effect of COVID-19 on accessibility and acceptance of contraception and safe abortion care services.Methods: Questionnaire survey was Done among 500 women in 6 months from April to September 2020, on availability and utilization of safe abortion and contraception services during lock down in covid time from patients getting treatment by Department of Obstetrics and Gynecology, Muzaffarnagar Medical College and health care workers (paramedics and others staff) of reproductive age group working in the institute.Results: Majority (56%) of women were in the age group of 20-30 years. 70% of women have access to contraception at present while it was reduced to 60% during lockdown. Most commonly used method was barrier method (70%) followed by OCP’s which they could avail maximum from pharmacy (40%). 65% of women had access to post delivery and post abortion contraception with most common method adopted being injectables, in 3% cases IUCD was inserted, 1% ligation with LSCS. Among them 42 cases were covid positive who underwent caesarean section and adopted contraception thereafter with tubal ligation in 2 cases.  In this study 32% of women had unwanted pregnancy, among them 35% underwent surgical abortion 61% medical abortion and 4% continued pregnancy.Conclusions: The COVID-19 pandemic has impacted safe abortion and contraception services. Unwanted pregnancy increased to 32%. 62% subjects claimed for accessibility at government centre and door to door by health worker

Machining Characteristics and Parametric Optimisation of Inconel 825 during Electric Discharge Machining

This paper presents the machining characteristics and parametric optimisation of Inconel 825 during die-sinking electrical discharge machining (EDM) process. This work considers seven input parameters out of which six are of three levels and one is of one level. Metal removal rate (MRR), tool wear rate (TWR) and surface roughness (SR) have been considered as performance measures. Before carrying out physical experimental runs, the experiments have been designed using Taguchi’s L36 (21 × 36) orthogonal array (OA). In order to identify the significant input parameters, Analysis of Variance has been employed on the experimental data. Discharge current, pulse-on-time, tool material and tool electrode lift time are found as significant input parameters. The effects of these significant parameters on the performance measures have been presented using Taguchi\u27s technique. After machining, study of surface characteristics of the electric discharged machined surface has been carried out using scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDXS) and X-ray diffraction (XRD). These studies help in obtaining the information pertaining to topography of the machined surface, material transfer from tool and dielectric to the machined surface, and presence of extra element and their different phases at the machined surface. It has been found from the research that Carbon, Oxygen, Iron, Nickel, Chromium and little amount of Molybdenum are transferred to the surface of work piece. Further, for the best yield of the process, the optimal combination of input parameters has been obtained and reported using Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) as a multi-objective optimisation technique. Consideration of two different dielectric fluids and three different electrode materials is the novelty of the work

Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

A voluminous literature suggests that an increase in consumption of fruit and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of cancer. The beneficial effect is mostly associated with the presence of phytochemicals in the diet. This review focuses on a group of them, namely isothiocyanate, curcumin, genistein, epigallocatechin gallate, lycopene and resveratrol, largely studied as chemopreventive agents and with potential clinical applications. Cellular and animal studies suggest that these molecules induce apoptosis and arrest cell growth by pleiotropic mechanisms. The anticancer efficacy of these compounds may result from their use in monotherapy or in association with chemotherapeutic drugs. This latter approach may represent a new pharmacological strategy against several types of cancers. However, despite the promising results from experimental studies, only a limited number of clinical trials are ongoing to assess the therapeutic efficacy of these molecules. Nevertheless, the preliminary results are promising and raise solid foundations for future investigations

Study Of Awareness And knowledge Of Pap Smear As A Screening Test For Cervical Cancer

Background: Cancer is a leading cause of death in females in age group of 35–65 years. Cervical cancer is the fourth most common cancer in females worldwide. The primary cause of this cancer is infection with humanpapillomavirus.Human papillomavirus (HPV) is a DNA virus that pass through skin-to-skin contact and sexual intercourse. Objective: The aim of this study is to assess the awareness about Pap smear and clinical utility. Material and method: This clinical study was carried out to assess the awareness about Pap smear, to identify their attitude towards Pap smear and to assess specificity of Pap smear for detection of cervical cancer in the Department Of Obstetrics and Gynecology, Muzaffarnagar Medical College, Muzaffarnagar. The total sample size was determined to be 500 subjects. Questionnaire survey was done from OPD patients of obstetrics and gynaecology Department, healthcare workers (paramedics and others ) of reproductive age group working in the institute at muzaffarnagar medical college and hospital, muzaffarnagar.Women who were already undergone Pap smear at least once were encouraged to get it done again if she is under that time duration, while remaining women were encouraged to undergo Pap smear test. Results: Six months data (September-February) 2019-2020 were collected. Out of 500 participants 208 participants were aware of cervical cancer and 120 participants were aware of Pap smear. Among 500 participants 413 underwent Pap smear. In our study, 24 % (120/500) of participants are aware of Pap smear out of which 86.66 % (104/120) say it is for early detection of cervical cancer. Time interval to repeat Pap smear in every 3 years is said by 45 % (54/120) and best timing to do the test is 10th to 20th days of menstrual cycle said by 35% (42/120). However, scoring of knowledge suggests only 19.16 % (23/120) is having adequate knowledge, i.e. they have given correct answer to all the three questions. Conclusion: Knowledge about Pap smear and cervical cancer was important in predicting Pap test doing. In addition, inadequate knowledge was introduced as the most important barrier to screening test from the perspective of women. The Pap test has fairly good specificity in detection of cervical pathology in asymptomatic women

Comparative analysis of conventional cytology and liquid-based cytology in the detection of carcinoma cervix and its precursor lesions

Context: The conventional smears (CS) and Liquid based cytology (LBC) are important tools to detect carcinoma cervix and its precursor lesions. Aims: The present study was done to compare the cytomorphological features of cervical lesions using both techniques and compare with the histopathological diagnosis. Settings and Design: This was a prospective observational study over a period of 1.5 years at a tertiary care hospital. Methods and Material: A total of 969 women in the age group of 21–65 years presenting with either routine screening or complaints of vaginal bleeding, discharge, or pelvic pain were enrolled for the study. Both the CS and LBC smears were analyzed and compared with the corresponding histopathology diagnosis. The data was analyzed using Statistical Package for the Social Sciences (SPSS) software and P values <0.05 were considered significant. Results: There were 8.57% unsatisfactory smears in CS as compared to 0.5% in LBC smears. Liquid-based cytology was superior to conventional preparations in terms of smear adequacy, lesser hemorrhagic and inflammatory background, and presence of more endocervical cells. Liquid-based cytology showed a better yield in detecting all the types of epithelial cell lesions with a concordance rate of 73.9% between the two techniques. On histopathology correlation of these lesions, LBC had a higher sensitivity (96.67%) and diagnostic accuracy (99.08%) as compared to CS (73.33% and 92.66%, respectively). Conclusions: Liquid-based cytology is superior to conventional cytology for the detection of epithelial cell lesions. Reduction in the unsatisfactory smears, a cleaner background, and better representation of the sample are more significantly appreciated on LBC in contrast to CS

A simple wire design to protect the gums during inter-proximal stripping

Introduction: Protection of gingiva during the inter-proximal reduction (IPR) is very essential and it is one of the most difficult tasks during IPR. Clinical Innovation: Present innovation discusses the chair-side construction of a simple wire design and its clinical use to prevent the gingival trauma during IPR. Discussion: During the IPR interproximal, gingiva should be protected by an indicator device. This wire design protects the gingiva from interproximal strips or burs during IPR. It has advantages of ease of use and can be sterilize for reuse