3,047 research outputs found
A putative resistant DNA marker for wool yellowing susceptibility in sheep.
An Australian Merino flock was screened for low (resistant) and high (susceptible) yellow predictive colour (YPC) breeding values in order to compare extreme individuals using the differential display of mRNA technique. One differentially expressed cDNA band was visualised only in the resistant group. This band showed no identity with the DNA sequences of public databases; however, they showed short homologies with three database sequences related to transmembrane signalling functions. The use of these candidate genes as DNA markers needs to be confirmed against sheep with a wide range of susceptibility to wool yellowing to verify the results
Meta-analysis of effect of nintedanib on reducing FVC decline across interstitial lung diseases
INTRODUCTION: The effect of nintedanib on slowing the rate of decline in forced vital capacity (FVC) has been investigated in randomized placebo-controlled trials in subjects with idiopathic pulmonary fibrosis (IPF), other progressive fibrosing interstitial lung diseases (ILDs), and ILD associated with systemic sclerosis (SSc-ILD). We assessed the consistency of the effect of nintedanib on the rate of decline in FVC over 52 weeks across four placebo-controlled phase III trials. METHODS: We used data on FVC decline from the INPULSIS-1 and INPULSIS-2 trials in subjects with IPF, the INBUILD trial in subjects with progressing fibrosing ILDs other than IPF, and the SENSCIS trial in subjects with SSc-ILD. In each trial, the primary endpoint was the annual rate of decline in FVC (mL/year) assessed over 52 weeks. We performed fixed effect and random effects meta-analyses based on the relative treatment effect of nintedanib versus placebo on the rate of decline in FVC (mL/year) over 52 weeks. Heterogeneity of the relative treatment effect of nintedanib across populations was assessed using the I2 statistic, τ2 and corresponding p value from a Q test for heterogeneity. RESULTS: The combined analysis comprised 1257 subjects treated with nintedanib and 1042 subjects who received placebo. Nintedanib reduced the rate of decline in FVC (mL/year) over 52 weeks by 51.0% (95% CI 39.1, 63.0) compared with placebo. The relative effect (95% CI) was the same using the fixed effect and random effects models. There was no evidence of heterogeneity in the relative treatment effect of nintedanib across the populations studied (I2 = 0%, τ2 = 0, p = 0.93). CONCLUSIONS: A meta-analysis of data from four placebo-controlled trials demonstrated that nintedanib approximately halved the rate of decline in FVC over 52 weeks across subjects with different forms of pulmonary fibrosis, with no evidence of heterogeneity in its relative treatment effect across patient populations
Extracellular Ca2+ stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblasts
Perturbations of a Universe Filled with Dust and Radiation
A first-order perturbation approach to Friedmann cosmologies filled
with dust and radiation is developed. Adopting the coordinate gauge comoving
with the perturbed matter, and neglecting the vorticity of the radiation, a
pair of coupled equations is obtained for the trace of the metric
perturbations and for the velocity potential . A power series solution with
upwards cutoff exists such that the leading terms for large values of the
dimensionless time agree with the relatively growing terms of the dust
solution of Sachs and Wolfe.Comment: 9 pp, typeset in late
Neutral H density at the termination shock: a consolidation of recent results
We discuss a consolidation of determinations of the density of neutral
interstellar H at the nose of the termination shock carried out with the use of
various data sets, techniques, and modeling approaches. In particular, we focus
on the determination of this density based on observations of H pickup ions on
Ulysses during its aphelion passage through the ecliptic plane. We discuss in
greater detail a novel method of determination of the density from these
measurements and review the results from its application to actual data. The H
density at TS derived from this analysis is equal to 0.087 \pm 0.022 cm-3, and
when all relevant determinations are taken into account, the consolidated
density is obtained at 0.09 \pm 0.022 cm-3. The density of H in CHISM based on
literature values of filtration factor is then calculated at 0.16 \pm 0.04
cm-3.Comment: Submitted to Space Science Review
The Radio - 2 mm Spectral Index of the Crab Nebula Measured with GISMO
We present results of 2 mm observations of the Crab Nebula, obtained using
the Goddard-IRAM Superconducting 2 Millimeter Observer (GISMO) bolometer camera
on the IRAM 30 m telescope. Additional 3.3 mm observations with the MUSTANG
bolometer array on the Green Bank Telescope are also presented. The integrated
2 mm flux density of the Crab Nebula provides no evidence for the emergence of
a second synchrotron component that has been proposed. It is consistent with
the radio power law spectrum, extrapolated up to a break frequency of
log(nu_{b} [GHz]) = 2.84 +/- 0.29 or nu_{b} = 695^{+651}_{-336} GHz. The Crab
Nebula is well-resolved by the ~16.7" beam (FWHM) of GISMO. Comparison to radio
data at comparable spatial resolution enables us to confirm significant spatial
variation of the spectral index between 21 cm and 2 mm. The main effect is a
spectral flattening in the inner region of the Crab Nebula, correlated with the
toroidal structure at the center of the nebula that is prominent in the near-IR
through X-ray regime.Comment: Accepted for publication in the Ap
Hierarchically Porous Gd3+-Doped CeO2 Nanostructures for the Remarkable Enhancement of Optical and Magnetic Properties
Rare earth ion-doped CeO2 has attracted more and more attention because of its special electrical, optical, magnetic, or catalytic properties. In this paper, a facile electrochemical deposition route was reported for the direct growth of the porous Gd-doped CeO2. The formation process of Gd-doped CeO2 composites was investigated. The obtained deposits were characterized by SEM, EDS, XRD, and XPS. The porous Gd3+- doped CeO2 (10 at% Gd) displays a typical type I adsorption isotherm and yields a large specific surface area of 135 m2/g. As Gd3+ ions were doped into CeO2 lattice, the absorption spectrum of Gd3+-doped CeO2 nanocrystals exhibited a red shift compared with porous CeO2 nanocrystals and bulk CeO2, and the luminescence of Gd3+-doped CeO2 deposits was remarkably enhanced due to the presence of more oxygen vacancies. In addition, the strong magnetic properties of Gd-doped CeO2 (10 at% Gd) were observed, which may be caused by Gd3+ ions or more oxygen defects in deposits. In addition, the catalytic activity of porous Gd-doped CeO2 toward CO oxidation was studied
A Decolonial Critique of the Racialized “Localwashing” of Extraction in Central Africa
Responding to calls for increased attention to actions and reactions “from above” within the
extractive industry, we offer a decolonial critique of the ways in which corporate entities and multinational institutions propagate racialized rhetoric of “local” suffering, “local” consultation, and “local” fault for failure in extractive zones. Such rhetoric functions to legitimize extractive intervention within a set of practices that we call localwashing. Drawing from a decade of research on and along the Chad-Cameroon Oil Pipeline, we show how multi-scalar actors converged to assert knowledge of, responsibility for, and collaborations with “local” people within a racialized politics of scale. These corporate representations of the racialized “local” are coded through long-standing colonial tropes. We identify three interrelated and overlapping flexian elite rhetoric(s) and practices of racialized localwashing: (a) anguishing, (b) arrogating, and (c) admonishing. These elite representations of a racialized “local” reveal diversionary efforts “from above” to manage public opinion, displace blame for project failures, and domesticate dissent in a context of persistent scrutiny and criticism from international and regional advocates and activists
Testing nonperturbative techniques in the scalar sector of the standard model
We discuss the current picture of the standard model's scalar sector at
strong coupling. We compare the pattern observed in the scalar sector in
perturbation theory up to two-loop with the nonperturbative solution obtained
by a next-to-leading order 1/N expansion. In particular, we analyze two
resonant Higgs scattering processes, ff -> H -> f'f' and ff -> H -> ZZ, WW. We
describe the ingredients of the nonperturbative calculation, such as the
tachyonic regularization, the higher order 1/N intermediate renormalization,
and the numerical methods for evaluating the graphs.
We discuss briefly the perspectives and usefulness of extending these
nonperturbative methods to other theories
- …