Risk Taking in Opportunity Evaluation

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Effects of Chamomile Essential Oil on Granulocyte Count In Patients with Neutropenia

Introduction Neutropenia is an abnormality in neutrophil count which lessens to lower than 1500 / microL (<1.5×109/L). Early recognition and treatment are needed in neutropenia cases. Matricaria chamomilla (chamomile) belongs to Asteracea family which often is referred as "star among medicinal species". Recently, valuable effects of chamomile in multitherapy, cosmetics and nutrition has been published in several papers. The phytochemical analysis exhibited flavonoids, essential oils, cumarins and sesquiterpene lactones derivatives like matricin and chamazulene in the plant. The aim of this research wasevaluation of chamomile essential oil on granulocyte count in patients with neutropenia. Methods and Results Essential oil of chamomile was collected consecutively via Clevenger method.  85 people were participated in the clinical trial and divided into three groups. 15 healthy people as control group received chamomile drop, 35 neutropenia patients induced by chemotherapy received chamomile drop as treatment group and 35 neutropenia patients induced by chemotherapy did not receive the drop as non-treated group. Blood sampling was done at the time of the admission and every other day for 10 consecutive days after chamomile drop consumption. Granulocytes, polymorphonuclear cells (PMNs) and white blood cells (WBC) were counted after every sampling. The average of WBC, PMNs and granulocytes numbers were significantly raised in control and treatment group with P<0.05 90±11/ 3520±611, 1.14±0.83/ 17.37±22.8 and 150±0.07/ 1537±305, respectively. In non-treated group the WBC, PMNs and granulocyte were 40±72, 7.91±22.96 and 190±48, respectively.        ConclusionConsumption of chamomile drop significantly increased the level of WBC, PMNs and granulocyte in control and treatment groups in comparison to non-treated group. As the result, chamomile essential oil could be considered as an adjuvant in neutropenia or other immune system deficiencies

Investigating the Role of Auger Recombination on the Performance of a self-assembled Quantum Dot Laser

We first examine the relaxation dynamics inside quantum dot structures. After presenting the rate equations model, we investigate the effect of some parameters introduced in the rate equation on the performance of quantum dot lasers. The effects of QDs coverage factor, inhomogeneous broadening, which its physical source is the size fluctuation of quantum dot in forming self-assembled quantum dots, as well as cavity length, on SAQD laser have been analyzed. Then, based on the rate equations, a circuit model will be introduced. Finally the effect of phonon bottleneck and Auger recombination on the performance of quantum dot lasing, are examined. It is shown that, there is more output power and quantum efficiency, and higher modulation bandwidths when Auger recombination is considered for these lasers

A Survey on Process Modelling, Innovation, Design, and Material Characterisation in Additive Manufacturing

The unique design freedom offered by additive manufacturing (AM) technologies enables engineers to develop more innovative products with relatively lower costs within a shorter period of processing time in comparison with conventional manufacturing methods. On the other hand, the unique capabilities of AM have created a platform for researchers to combine several engineering methods with the new manufacturing technique to grow industrial applications as well as resolve the existing issues with AM processes. Understanding the research values that AM offers academic environments, this paper performs a systematic survey on AM-related research topics in the fields of mechanical engineering and materials science that have attracted much attention from research teams over the last few years. These topics, namely process modelling in AM, innovative research in AM, generative design by AM, material characterisation in AM processes, and finally, design for additive manufacturing (DfAM), are notably investigated through this study

Familial colorectal cancertype X in central Iran: A new clinicopathologic description

Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatchrepair (MMR)-proficient colorectal cancerin whichthe patients are clinicallyat risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome.In this study, we describeda new clinicopathological feature of the condition in central Iran. Subjects and Methods: We designed a descriptive, retrospective study to screenat-riskcolorectal cancer (CRC) patients,usingAmsterdam II criteria and Molecular analysis in Isfahan (central Iran) throughout 2000-2013 period. Results: 219 early-onset (≤ 50 years) CRC patients of 1659 were selected for the evaluation. Amsterdam II criteria were positive in 45 families; of whom 31 were finally analyzed by molecular testing. MMR deficiency was detected in 7/31 probands (22.6%) as affected to LS, so 24 families (77.4%) were identified as FCCX. The mean age of the probands at diagnosis among FCCX families was 45.3 years (range 24-69) versus 38.0 years (range 31-50) in LS families.The frequency of CRC among FCCX and LS families was calculated 27.9% and 67.5%, respectively. Also, the most frequent extracolonic cancer among both FCCX and LS families was stomach by 25.5% and 30.8%, respectively. Tumor site was proximal to the splenic flexure in 20.8% and 57.1% of index CRC patients in FCCX and LS families, respectively. Conclusion: Given the relative high frequency of FCCXand its different phenotype among Iranian populations, we need to set up more advanced molecular studies for exploration of unknown molecular pathways leading to tumorigenesis in this class of CRC patients

The efficacy of metacognitive therapy on emotional processing components of patients with functional dyspepsia: controlled clinical trial

Background: Functional dyspepsia is characterized by a set of symptoms in the upper gastrointestinal tract due to an underlying organic cause and is one of the common causes of patients ’visits to gastroenterologists. A few researches have been conducted on the effectiveness of psychotherapy with respect to the psychological components of these patients. Therefore, the purpose of this study is to investigate the effect of metacognitive therapy on emotional processing components of these patients. Materials and Methods: In this study, 40 patients with dyspeptic symptoms were recruited after medical examination by gastroenterologists, performing H. Pylori test and undergoing endoscopy. Moreover, 20 of the patients were randomly assigned to a group for metacognitive therapy and another 20 to the control group. The Baker's emotional processing questionnaire was used at pre-treatment, post-treatment and three months after treatment for evaluating changes in patients' emotional processing styles. Finally, repeated measures analysis of variance was employed for data analysis by using SPSS 19. Results: The research data that was obtained by repeated measures analysis of variance indicated statistically significant differences in three emotional processing scales in metacognitive therapy group compared to the control group at pre-treatment, post-treatment and three months after treatment. Conclusion: Compared to the control group, the metacognitive therapy of functional dyspepsia patients was more effective in the short- and long-term for coping with difficulty in emotional recognition and experience, difficulty in emotional control and expression as well as inadequate emotional processin

Effect of Squill Oxymel on Knee Osteoarthritis: A Triple-Blind, Randomized, Controlled Clinical Trial

Osteoarthritis (OA) of the knee is a major health problem in the society. Iranian Traditional Medicine (ITM) or Persian Medicine (PM) as a branch of complementary medicine has been practiced in Iran for many centuries. An herbal medication known as squill oxymel has been used by PM physicians for OA. Our aim is to investigate the effect of squill oxymel on OA of the knee joint. Eighty eight patients were assigned to receive a placebo or squill oxymel syrup (10 ml each morning on empty stomach) for 8 consecutive weeks. Acetaminophen tablets were considered as the rescue medicine. Ultimately, 43 patients in the placebo group and 40 patients in the treatment group completed the trial and were included in the statistical analysis. Patients were followed for 4 weeks after cessation of treatment. The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire and Visual Analog Scale (VAS) were considered as the main outcome measures. Laboratory tests including AST, ALT, BUN, Cr plus inflammatory tests including WBC, ESR, and CRP with specific tests i.e. IL6 and SOD at the beginning and the end of intervention were measured. The results showed the positive effect of treatment on the outcome of knee pain (p=0.04) and daily activity (p=0.01) of KOOS after Cessation of treatment. On the other hand, VAS decreased in both treatment and placebo groups while it showed significance intra-group and showed no significance between the two groups. After 4 weeks of cessation of treatment, the positive effect of the squill oxymel on the treatment group continued in some of the subscales of KOOS, including symptoms, knee pain and daily activities, but stopped in the placebo group. In general, both clinically and statistically significant improvement was observed after cessation of treatment. Squill oxymel syrup showed promising results in management of knee OA but future researches with larger sample size and longer duration are necessary