Synthesis of some ethyl 2-arylamino-5-phenylthiothiazole-4-carboxylates and their sulphones as potential analgesic, antiinflammatory and antimicrobial agents

1074-107

Mass spectra of some 1,3, 4-thiadiazole derivatives

Mass spectral fragmentation of some 2-aryl-amino-5-alkyl-1,3,4-thiadiazoles and 2-alkyl-6-arylimidazo[2,1-b]-2,3,4-thiadiazoles have been studied with the help of high resolution and metastable ion spectra. McLafferty rearrangement involving the gamma-hydrogen transfer from the alkyl chain dominates the mass spectra of many of the compounds. Preferable cleavage of C-C bond between C-2 and C-3 of the alkyl chain is also observed

Synthesis and biological activity of some 3-methyl/ethoxycarbonyl-6- arylimidazo[2,1<i>-b</i>]thiazoles and their 5-bromo/5-formyl derivatives

393-398Facile reaction of arylacylbromide 1 with 2-amino-4- methylthiazole 2 and its hindered reaction with 2-amino-4-ethoxycarbonylthiazole 3 during the synthesis of 3-methyl/ethoxycarbonyl-6-aryl imidazo[2,1-b] thiazoles 8/9 are explained on the basis of electronic effects of the 4-substituent of thiazole substrate. Their bromination/formylation afforded the corresponding 5-bromo and 5-formyl derivatives . Results of preliminary screening of the target compounds reveal moderate anthelmintic and anti-inflammatory activity