Design and Development of Prosthetic Legs

The purpose of this article is to describe the development in prosthetic legs. Artificial limbs may be needed for a variety of reasons including diseases, accidents and congenital defects. As the human body changes over time due to growth or change in body weight, the artificial limbs have to be changed and adjusted periodically. This constant need for change or adjustment may become costly if the material used is expensive. This study will emphasis the prosthetic legs by focusing on the socket part as it is often changed and replaced with natural-based bio composites. The results of this study are based on the compatibility of the properties of existing and proposed materials which contribute towards providing alternative materials that are more cost efficient, eco-friendly and yet maintaining the features required for artificial limbs. The findings are expected to help patients or wearers to live independently when they are young, who cannot afford to have this essentially

Hyperlop Transportation System

As we know that there are four modes of transportation are, rail, road, water, and air. These modes of transport tend to be either relatively slow (e.g., road and water), expensive (e.g., air), or a combination of relatively slow and expensive (i.e., rail). Hyper loop is a new mode of transport that seeks to change this paradigm by being both fast and inexpensive for people and goods. Hyperloop is also unique in that it is an open design concept, similar to Linux. Feedback is desired from the community that can help advance the Hyperloop design and bring it from concept to reality. Hyperloop consists of a low pressure tube with capsules that are transported at both low and high speeds throughout the length of the tube. The capsules are supported on a cushion of air, featuring pressurized air and aerodynamic lift. The capsules are accelerated via a magnetic linear accelerator affixed at various stations on the low pressure tube with rotors contained in each capsule. Passengers may enter and exit Hyperloop at stations located either at the ends of the tube, or branches along the tube length. In this study, the initial route, preliminary design, and logistics of the Hyperloop transportation system have been derived. The system consists of capsules that travel between Los Angeles, California and San Francisco, California. The total one-way trip time is 35 minutes from county line to county line. The capsules leave on average every 2 minutes from each terminal carrying 28 people each (as often as every 30 seconds during rush hour and less frequently at night). This gives a total of 7.4 million people per tube that can be transported each year on Hyperloop. The total cost of Hyperloop is under $6 billion USD for two one-way tubes and 40 capsules. Amortizing this capital cost over 20 years and adding daily operational costs gives a total of$20 USD plus operating costs per one-way ticket on the passenger Hyperloop

Air Bearing and its Stability

Bearing are machine element that allow components to move with respect to each other. A little consideration will shows that some part of power wasted in overcoming the frictional resistance and due to the contact of surfaces large amount of wear and tear takes place between the contacted surfaces. Hence to avoid wear and tear in sliding contact bearing and to reduce frictional resistance the thin layer of fluid is introduced which is called as lubricant. Air bearing are introduced to reduce such frictional resistance and wear of sliding contact bearings. Air bearings are bearings that use a thin film of pressurized air to provide low frictional load bearing interfaces between surfaces. There is a small gap between two surfaces i.e. two surfaces do not touch. As these bearings are contact free various problems in traditional bearing like friction, wear, particulates, and lubricant handling are avoided. There are advantages like precision positioning, such as lacking backlash and static friction as well as in high speed application. Other than this characteristics, stability is also important factor in air bearing

Review on Automotive Body Coating Process

Automotive coatings and the processes used to coaat automobile surfaces exemplify the avant-grade of technologies that are capable of producing durable surfaces, exceeding customers expections of apperance, maximizing efficiency, and meeting environmental regulations. These accomplishments are rooted in 100 years of experience, trial-and-error approaches, technique and technology advancements, and theroetical assessments. Because of advancenments directed at understanding the how, why, when, and where of automobile coatings, the progress in controlling droplets and their deposition attributes, and the development of new technologies and paint chemistries, a comprehensive and up-to-date review of automobile coating and coating technologies was considered to be a value to industrial practitioners and  researches.                                                 Overall the critical performance factors driving the development and use of advanced automotive coatings and coating technologies are (a) aesthetic characteristics; (b) corrosion protection; (c) mass production; (d) cost and environmental requirements; (e) appearance and durability. Although the relative importance of each of these factors is debatable, the perfection of any one at the expense of another would be unacceptable. Hence, new developments in automotive coatings are described and discussed in the following review, and then related to improvements in production technologies& paints. Modern automotive coating procedure are also discussed in details

Increased risk of early-onset preeclampsia in pregnant women with COVID-19

Objective To estimate incidence, risk of early and late-onset preeclampsia (PE) and understand their relationship with severity of COVID-19. Methods Pregnant women with COVID-19 (n = 1929) were enrolled from 1 April 2020 to 24 February 2022. Primary outcome measure was incidence and risk of early onset PE in women with COVID-19. Results The incidence of early and late-onset PE was 11.4% and 5.6%. Moderate to severe COVID-19 was associated with eight times higher risk of early onset PE [aOR = 8.13 (1.56–42.46), p = 0.0129] compared to asymptomatic group. Conclusions Risk of early onset PE was higher in pregnant women with symptomatic COVID-19 as compared to asymptomatic women

Management of coronary disease in patients with advanced kidney disease

BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed. The primary outcome was a composite of death or nonfatal myocardial infarction. A key secondary outcome was a composite of death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. RESULTS At a median follow-up of 2.2 years, a primary outcome event had occurred in 123 patients in the invasive-strategy group and in 129 patients in the conservative-strategy group (estimated 3-year event rate, 36.4% vs. 36.7%; adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.79 to 1.29; P=0.95). Results for the key secondary outcome were similar (38.5% vs. 39.7%; hazard ratio, 1.01; 95% CI, 0.79 to 1.29). The invasive strategy was associated with a higher incidence of stroke than the conservative strategy (hazard ratio, 3.76; 95% CI, 1.52 to 9.32; P=0.004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04 to 2.11; P=0.03). CONCLUSIONS Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction

Health status after invasive or conservative care in coronary and advanced kidney disease

BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1.73 m2 or receipt of dialysis). A secondary objective of the trial was to assess angina-related health status. METHODS We assessed health status with the Seattle Angina Questionnaire (SAQ) before randomization and at 1.5, 3, and 6 months and every 6 months thereafter. The primary outcome of this analysis was the SAQ Summary score (ranging from 0 to 100, with higher scores indicating less frequent angina and better function and quality of life). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate the treatment effect with the invasive strategy. RESULTS Health status was assessed in 705 of 777 participants. Nearly half the participants (49%) had had no angina during the month before randomization. At 3 months, the estimated mean difference between the invasive-strategy group and the conservative-strategy group in the SAQ Summary score was 2.1 points (95% credible interval, 120.4 to 4.6), a result that favored the invasive strategy. The mean difference in score at 3 months was largest among participants with daily or weekly angina at baseline (10.1 points; 95% credible interval, 0.0 to 19.9), smaller among those with monthly angina at baseline (2.2 points; 95% credible interval, 122.0 to 6.2), and nearly absent among those without angina at baseline (0.6 points; 95% credible interval, 121.9 to 3.3). By 6 months, the between-group difference in the overall trial population was attenuated (0.5 points; 95% credible interval, 122.2 to 3.4). CONCLUSIONS Participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease did not have substantial or sustained benefits with regard to angina-related health status with an initially invasive strategy as compared with a conservative strategy