A Call for the Structured Physicist Report

Introduction: The field of diagnostic radiology continues to struggle with the clinical adoption of the structured interpretive report, with many radiologists preferring a semistructured, free-text dictation style to a more rigid, highly structured approach that some professional leaders have promoted [1]. Although structured reporting compliance in the radiologist community has been difficult to achieve, diagnostic radiologists have been thinking about and discussing this important issue for many years; it is also a part of the ACR’s Imaging 3.0_ campaign [2]. In the breast imaging community, the well-established BI-RADS_ recommendations produce a very structured report, with a discussion of interpretive findings culminating in a numeric BI-RADS score ranging from 0 to 6 [3]. Unlike some interpretive radiology reports, which can be ambiguous in terms of the next course of action, the BI-RADS scale is not only a diagnostic scale but also prescriptive of what the necessary follow-up should be

Kinetics of Oxidation of Cinnamyl Alcohol with Chloramine- T in Hydrochloric Acid Medium

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Kinetics and mechanism of oxidation of erythro-series pentoses and hexoses by N-chloro-p-toluenesulfonamide

The kinetics and mechanism of oxidation of D-glucose, D-mannose, D-fructose, D-arabinose, and D-ribose with chloramine-T in alkaline medium were studied. The rate law, rate = k Chloramine-T] Sugar] HO-](2), was observed. The rate of the reaction was influenced by a change in ionic strength of the medium, and the dielectric effect was found to be negative. The latter enabled the computation of d(AB), the size of the activated complex. The reaction rate was almost doubled in deuterium oxide. Activation energies were calculated from the Arrhenius plots. HPLC and GLC-MS analyses of the products indicated that the sugars were oxidized to a mixture of aldonic acids, consisting of arabinonic, ribonic, erythronic, and glyceric acids. Based on these data, a plausible mechanism involving the aldo-enolic anions of pentoses and keto-enolic anions of hexoses is suggested. (C) 1998 Elsevier Science Ltd. All rights reserved

Simulation of Electrode-Tissue Interface with Biphasic Pulse Train for Epiretinal Prosthesis

Abstract: Retinitis Pigmentosa (RP) and Agerelated Macular Degeneration (AMD) are diseases causing blindness in a large number of people. In this type of degenerative disease, mostly the photoreceptors are damaged, and thus attempts have been made to electrically stimulate the surviving inner retinal neurons and retinal ganglion cells (RGC) in order to restore vision. In this paper, the electrode-tissue interface is modeled to study the effect of electrode size and distance between the electrode and retina by applying biphasic pulse trains similar to in-vitro experiments and in-vivo trials. Simulations were carried out using the AC/DC module of COMSOL v4.3a with planer electrodes placed over the constitutive layers of retina. Biphasic pulses with varying pulse width, inter pulse interval and amplitude were applied to the stimulating electrode. The model is solved for time and frequency domain. Electric potential in the RGC layer was found to vary both as a function of electrode diameter and distance of the electrode

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P < 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P < 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training

For reproductive justice in an era of Gates and Modi – the violence of India’s population policies

This article addresses India’s contemporary population control policies and practices as a form of gendered violence perpetrated by the state and transnational actors, arguing that the targeting of poor, Adivasi and Dalit women for coercive mass sterilizations and unsafe injectable and implantable contraceptives is made possible by the long-term construction of particular women’s lives as devalued and disposable, and of their bodies as excessively fertile and therefore inimical to development and progress. It further considers how population policy is currently embedded in the neoliberal framework of development being pursued by the Indian state. In particular, it argues that the violence of population policies is being deepened as a result of three central and interrelated aspects of this framework: corporate dispossession and displacement, the intensification and extension of women’s labour for global capital, and the discourses and embodied practices of Hindu supremacism. At the same time, India’s population policies cannot be understood in isolation from the global population control establishment, which is increasingly corporate led, and from broader structures of racialised global capital accumulation. The gendered violence of India’s contemporary population policies and the practices they produce operates at several different scales, all of which involve the construction of certain bodies as ‘unfit’ to reproduce and requiring intervention and control

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. Platelet aggregation and calcium mobilization induced by the PAR4 thrombin receptor were significantly greater in black subjects. Numerous differentially expressed RNAs were associated with both race and PAR4 reactivity, including PCTP (encoding phosphatidylcholine transfer protein), and platelets from black subjects expressed higher levels of PC-TP protein. PC-TP inhibition or depletion blocked PAR4- but not PAR1-mediated activation of platelets and megakaryocytic cell lines. miR-376c levels were differentially expressed by race and PAR4 reactivity and were inversely correlated with PCTP mRNA levels, PC-TP protein levels and PAR4 reactivity. miR-376c regulated the expression of PC-TP in human megakaryocytes. A disproportionately high number of microRNAs that were differentially expressed by race and PAR4 reactivity, including miR-376c, are encoded in the DLK1-DIO3 locus and were expressed at lower levels in platelets from black subjects. These results suggest that PC-TP contributes to the racial difference in PAR4-mediated platelet activation, indicate a genomic contribution to platelet function that differs by race and emphasize a need to consider the effects of race when developing anti-thrombotic drugs

Kinetics of oxidation of glycine and valine by chloramine-T in hydrochloric acid medium

The kinetics of oxidation of glycine and valine by chloramine-T in hydrochloric acid medium has been studied. The rate of disappearance of chloramine-T shows a first order dependence on both chloramine-T and the amino acid, and an inverse first order with respect to [H+]. The solvent isotope effect was studied using heavy water. The kinetic parameters, Ea, Arrhenius factor A, ΔH≠ and ΔS≠ and ΔG≠ have been calculated. A rate law in agreement with experimental results has been derived. A mechanism is proposed