678 research outputs found
Monographies on drugs, which are frequently analysed in the course of Therapeutic Drug Monitoring Monographien ĂŒber Medikamente, die regelmĂ€ssig im Rahmen des Therapeutic Drug Monitorings analysiert werden
In 1995 the working group "Drug Monitoringâ of the Swiss Society of Clinical Chemistry (SSCC) has already published a printed version of drug monographs, which are now newly compiled and presented in a standardised manner. The aim of these monographs is to give an overview on the most important informations that are necessary in order to request a drug analysis or is helpful to interpret the results. Therefore, the targeted audience are laboratory health professionals or the receivers of the reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half life time and elimination routes as well as information on therapeutic or toxic concentrations. Because preanalytical considerations are of particular importance for therapeutic drug monitoring, there is also information given at which time the determination of the drug concentration is reasonable and when steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s), respectively, after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for you handling therapeutic drug monitoring and look forward to comments of the audienc
Formation of Liesegang patterns: A spinodal decomposition scenario
Spinodal decomposition in the presence of a moving particle source is
proposed as a mechanism for the formation of Liesegang bands. This mechanism
yields a sequence of band positions x_n that obeys the spacing law
x_n~Q(1+p)^n. The dependence of the parameters p and Q on the initial
concentration of the reagents is determined and we find that the functional
form of p is in agreement with the experimentally observed Matalon-Packter law.Comment: RevTex, 4 pages, 4 eps figure
Next-to-Leading Order Constituent Quark Structure and Hadronic Structure Functions
We calculate the partonic structure of a constituent quark in the
Next-to-Leading Order framework. The structure of any hadron can be obtained
thereafter using a convolution method. Such a procedure is used to generate the
structure function of proton and pion in NLO, neglecting certain corrections to
. It is shown that while the constituent quark structure is
generated purely perturbatively and accounts for the most part of the hadronic
structure, there is a few percent contributions coming from the nonperturbative
sector in the hadronic structure. This contribution plays the key role in
explaining the SU(2) symmetry breaking of the nucleon sea and the observed
violation of Gottfried sum rule. These effects are calculated. We obtained an
Excellent agreement with the experimental data in a wide range of and for the proton structure function. We
have also calculated Pion structure and compared it with the existing data.
Again, the model calculations agree rather well with the data from experiment.Comment: 32 pages,10 figures, Accepted to publish in Phys. Rev.
Localization-delocalization transition of a reaction-diffusion front near a semipermeable wall
The A+B --> C reaction-diffusion process is studied in a system where the
reagents are separated by a semipermeable wall. We use reaction-diffusion
equations to describe the process and to derive a scaling description for the
long-time behavior of the reaction front. Furthermore, we show that a critical
localization-delocalization transition takes place as a control parameter which
depends on the initial densities and on the diffusion constants is varied. The
transition is between a reaction front of finite width that is localized at the
wall and a front which is detached and moves away from the wall. At the
critical point, the reaction front remains at the wall but its width diverges
with time [as t^(1/6) in mean-field approximation].Comment: 7 pages, PS fil
Recent evolution of an iceâcored moraine at the Gentianes Pass, Valais Alps, Switzerland
International audienceLateral moraines located in permafrost environments often preserve large amounts of both glacier and periglacial ice. To understand how iceâcored moraines located in high alpine environments evolve in a context of both glacier retreat and permafrost degradation, we performed 11 terrestrial laserâscanning measurement campaigns between 2007 and 2014 on a highly anthropogenic overprinted moraine prone to instability. Resulting comparison of the subsequent 3D models allowed to qualitatively and quantitatively analyze the morphological evolution of the moraine. The comparisons indicate a very high geomorphic activity of the moraine including large areas affected by downslope movements of blocks and 10 landslides with a volume between 24 ± 1 and 1,138 ± 47 m3. Data also indicated a very strong ice melt with a loss of ice thickness locally reaching 17.7 m at the foot of the moraine. These results, compared with resistivity and thermal measurements of the ground, suggest the combined role of ice loss at the foot of the moraine and the permafrost activity/warming in triggering these processes
Investigating the Contribution of Mature Collagen Crosslinks to Cooked Meat Toughness Using a Stewed Beef Shank Model
Objective: The objective of this study was to investigate mature collagen crosslink densities and their relationship to connective tissue texture using a stewed beef shank model.
Study Description: Connective tissue texture, Warner-Bratzler shear force, and collagen content and characteristics were measured for six different beef shank cuts from eight U.S. Department of Agriculture Low Choice beef carcasses (n = 48).
Results: Deep digital flexor from the foreshank had the toughest connective tissue texture, greatest Warner-Bratzler shear force value, most cooked collagen content, one of the greatest insoluble collagen percentages, as well as greatest raw and cooked pyridinoline densities among all the beef shank cuts (P \u3c 0.05). Correlation analysis showed that cooked collagen content, percent insoluble collagen, as well as raw pyridinoline densities had positive correlations with connective tissue texture (r = 0.550, 0.498, and 0.560, respectively; P \u3c 0.01) and Warner-Bratzler shear force (r = 0.615, 0.392 and 0.730, respectively; P \u3c 0.05).
The Bottom Line: Pyridinoline is a heat stable collagen crosslink that is difficult to degrade even with extensive heat treatment. As a result, raw pyridinoline density is a good indicator for heat insoluble collagen content, cooked beef connective tissue texture, and ultimately, tenderness in beef cuts with high concentration of connective tissue prepared with moist heat cookery
A High Statistics Measurement of the Lambdac+ Lifetime
A high statistics measurement of the Lambdac+ lifetime from the Fermilab
fixed-target FOCUS photoproduction experiment is presented. We describe the
analysis technique with particular attention to the determination of the
systematic uncertainty. The measured value of 204.6 +/- 3.4 (stat.) +/- 2.5
(syst.) fs from 8034 +/- 122 Lambdac -> pKpi decays represents a significant
improvement over the present world average.Comment: Submitted to Physical Review Letter
Search for CP Violation in the decays D+ -> K_S pi+ and D+ -> K_S K+
A high statistics sample of photo-produced charm from the FOCUS(E831)
experiment at Fermilab has been used to search for direct CP violation in the
decays D+->K_S pi+ and D+ -> K_S K+. We have measured the following asymmetry
parameters relative to D+->K-pi+pi+: A_CP(K_S pi+) = (-1.6 +/- 1.5 +/- 0.9)%,
A_CP(K_S K+) = (+6.9 +/- 6.0 +/- 1.5)% and A_CP(K_S K+) = (+7.1 +/- 6.1 +/-
1.2)% relative to D+->K_S pi+. The first errors quoted are statistical and the
second are systematic. We also measure the relative branching ratios:
\Gamma(D+->\bar{K0}pi+)/\Gamma(D+->K-pi+pi+) = (30.60 +/- 0.46 +/- 0.32)%,
\Gamma(D+->\bar{K0}K+)/\Gamma(D+->K-pi+pi+) = (6.04 +/- 0.35 +/- 0.30)% and
\Gamma(D+->\bar{K0}K+)/\Gamma(D+->\bar{K0}pi+) = (19.96 +/- 1.19 +/- 0.96)%.Comment: 4 pages, 3 figure
A measurement of branching ratios of and hadronic decays to four-body final states containing a
We have studied hadronic four-body decays of and mesons with a
in the final state using data recorded during the 1996-1997 fixed-target
run at Fermilab high energy photoproduction experiment FOCUS. We report a new
branching ratio measurement of . We make the first observation
of three new decay modes with branching ratios ,
\Gamma(D^+\to\K_S K^+ K^-\pi^+)/\Gamma(D^+\to K_S
\pi^+\pi^+\pi^-)=0.0077\pm0.0015\pm0.0009, and , where
in each case the first error is statistical and the second error is systematic.Comment: 4 pages, 1 table, 2 figures, submitted to Physical Review Letter
A Measurement of the Ds+ Lifetime
A high statistics measurement of the Ds+ lifetime from the Fermilab
fixed-target FOCUS photoproduction experiment is presented. We describe the
analysis of the two decay modes, Ds+ -> phi(1020)pi+ and Ds+ ->
\bar{K}*(892)0K+, used for the measurement. The measured lifetime is 507.4 +/-
5.5 (stat.) +/- 5.1 (syst.) fs using 8961 +/- 105 Ds+ -> phi(1020)pi+ and 4680
+/- 90 Ds+ -> \bar{K}*(892)0K+ decays. This is a significant improvement over
the present world average.Comment: 5 pages, 3 figures, 2 tables, submitted to PR
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