Expanded Search for z~10 Galaxies from HUDF09, ERS, and CANDELS Data: Evidence for Accelerated Evolution at z>8?

We search for z~10 galaxies over ~160 arcmin^2 of WFC3/IR data in the Chandra Deep Field South, using the public HUDF09, ERS, and CANDELS surveys, that reach to 5sigma depths ranging from 26.9 to 29.4 in H_160 AB mag. z>~9.5 galaxy candidates are identified via J_125-H_160>1.2 colors and non-detections in any band blueward of J_125. Spitzer IRAC photometry is key for separating the genuine high-z candidates from intermediate redshift (z~2-4) galaxies with evolved or heavily dust obscured stellar populations. After removing 16 sources of intermediate brightness (H_160~24-26 mag) with strong IRAC detections, we only find one plausible z~10 galaxy candidate in the whole data set, previously reported in Bouwens et al. (2011). The newer data cover a 3x larger area and provide much stronger constraints on the evolution of the UV luminosity function (LF). If the evolution of the z~4-8 LFs is extrapolated to z~10, six z~10 galaxies are expected in our data. The detection of only one source suggests that the UV LF evolves at an accelerated rate before z~8. The luminosity density is found to increase by more than an order of magnitude in only 170 Myr from z~10 to z~8. This increase is >=4x larger than expected from the lower redshift extrapolation of the UV LF. We are thus likely witnessing the first rapid build-up of galaxies in the heart of cosmic reionization. Future deep HST WFC3/IR data, reaching to well beyond 29 mag, can enable a more robust quantification of the accelerated evolution around z~10.Comment: 13 pages, 11 figures, ApJ resubmitted after referee repor

Implementation of Vascularized Composite Allografts in the United States: Recommendations From the ASTS VCA Ad Hoc Committee and the Executive Committee

Like all other areas of transplantation, vascularized composite allografts (VCA) has the capacity to transform the lives of patients, for the better or for the worse. It is this duality that mandates VCA be performed in centers prepared for the intricacies accompanying other transplant procedures. Similarly, the complexities of VCA require that the procedures be driven by surgeons and physicians with experience in the multidisciplinary management of immunocompromised postsurgical patients. Furthermore, the grafts should be considered as organs rather than tissues from a regulatory and a biological standpoint. The ASTS supports the field of VCA and has demonstrated its support and leadership by actively formulating a strategy for its systematic development. The goal of this document is to provide a framework for the prospective, thoughtful realization of VCA in the United States from the American Society of Transplant Surgeons (ASTS) perspective.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79113/1/j.1600-6143.2010.03374.x.pd

UV Luminosity Functions from 132 z~7 and z~8 Lyman-Break Galaxies in the ultra-deep HUDF09 and wide-area ERS WFC3/IR Observations

We identify 73 z~7 and 59 z~8 candidate galaxies in the reionization epoch, and use this large 26-29.4 AB mag sample of galaxies to derive very deep luminosity functions to <-18 AB mag and the star formation rate density at z~7 and z~8. The galaxy sample is derived using a sophisticated Lyman-Break technique on the full two-year WFC3/IR and ACS data available over the HUDF09 (~29.4 AB mag, 5 sigma), two nearby HUDF09 fields (~29 AB mag, 14 arcmin) and the wider area ERS (~27.5 AB mag) ~40 arcmin**2). The application of strict optical non-detection criteria ensures the contamination fraction is kept low (just ~7% in the HUDF). This very low value includes a full assessment of the contamination from lower redshift sources, photometric scatter, AGN, spurious sources, low mass stars, and transients (e.g., SNe). From careful modelling of the selection volumes for each of our search fields we derive luminosity functions for galaxies at z~7 and z~8 to <-18 AB mag. The faint-end slopes alpha at z~7 and z~8 are uncertain but very steep at alpha = -2.01+/-0.21 and alpha=-1.91+/-0.32, respectively. Such steep slopes contrast to the local alpha<~-1.4 and may even be steeper than that at z~4 where alpha=-1.73+/-0.05. With such steep slopes (alpha<~-1.7) lower luminosity galaxies dominate the galaxy luminosity density during the epoch of reionization. The star formation rate densities derived from these new z~7 and z~8 luminosity functions are consistent with the trends found at later times (lower redshifts). We find reasonable consistency, with the SFR densities implied from reported stellar mass densities, being only ~40% higher at z<7. This suggests that (1) the stellar mass densities inferred from the Spitzer IRAC photometry are reasonably accurate and (2) that the IMF at very high redshift may not be very different from that at later times.Comment: 38 pages, 21 figures, 20 tables, ApJ, accepted for publicatio

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

The abundance of lysozyme on mucosal surfaces suggests that successful colonizers must be able to evade its antimicrobial effects. Lysozyme has a muramidase activity that hydrolyzes bacterial peptidoglycan and a non-muramidase activity attributable to its function as a cationic antimicrobial peptide. Two enzymes (PgdA, a N-acetylglucosamine deacetylase, and Adr, an O-acetyl transferase) that modify different sites on the peptidoglycan of Streptococcus pneumoniae have been implicated in its resistance to lysozyme in vitro. Here we show that the antimicrobial effect of human lysozyme is due to its muramidase activity and that both peptidoglycan modifications are required for full resistance by pneumococci. To examine the contribution of lysozyme and peptidoglycan modifications during colonization of the upper respiratory tract, competition experiments were performed with wild-type and pgdAadr mutant pneumococci in lysozyme M-sufficient (LysM+/+) and -deficient (LysM−/−) mice. The wild-type strain out-competed the double mutant in LysM+/+, but not LysM−/− mice, indicating the importance of resistance to the muramidase activity of lysozyme during mucosal colonization. In contrast, strains containing single mutations in either pgdA or adr prevailed over the wild-type strain in both LysM+/+ and LysM−/− mice. Our findings demonstrate that individual peptidoglycan modifications diminish fitness during colonization. The competitive advantage of wild-type pneumococci in LysM+/+ but not LysM−/− mice suggests that the combination of peptidoglycan modifications reduces overall fitness, but that this is outweighed by the benefits of resistance to the peptidoglycan degrading activity of lysozyme