Local multipunctual corticosteroid injections for medial tibial stress syndrome: a novel approach.

El síndrome de estrés medial de la tibia (SEMT) constituye una de las afecciones más comunes del miembro inferior. Los resultados obtenidos con terapias convencionales en esta patología son dispares. La infiltración local de corticoides ha mostrado producir efectos favorables en el tratamiento de diversos problemas musculoesqueléticos. Elefecto de la infiltración local multipuntual de un corticoide encombinación con un anestésico se estudió en 47 pacientes (29 hombres y 18 mujeres, con una edad media de 23.8) afectos de SEMT. La consulta directa y el examen físico se emplearon para valorar los resultados. Los pacientes fueron valorados una vez a la semana tras la primera aplicación durante las primeras cuatro semanas y 3 meses después del tratamiento. El nivel de actividad en ausencia de síntomas fue registrado en cada caso. Los resultados de la infiltración multipuntual se determinaron comparando los niveles de actividad en ausencia de síntomas preintervención y posintervención y la capacidad de los deportistas para volver a los niveles de actividad presintomáticos. Los resultados sugieren que este tratamiento reduce el tiempo de recuperación y mejora los resultados funcionales

The Lennard-Jones-Devonshire cell model revisited

We reanalyse the cell theory of Lennard-Jones and Devonshire and find that in addition to the critical point originally reported for the 12-6 potential (and widely quoted in standard textbooks), the model exhibits a further critical point. We show that the latter is actually a more appropriate candidate for liquid-gas criticality than the original critical point.Comment: 5 pages, 3 figures, submitted to Mol. Phy

Automated goal operationalisation based on interpolation and SAT solving

Goal oriented methods have been successfully employed for eliciting and elaborating software requirements. When goals are assigned to an agent, they have to be operationalised: the agent’s operations have to be refined, by equipping them with appropriate enabling and triggering conditions, so that the goals are fulfilled. Goal operationalisation generally demands a significant effort of the engineer. Although there exist approaches that tackle this problem, they are either in-formal or at most semi automated, requiring the engineer to assist in the process. In this paper, we present an approach for goal operationalisation that automatically computes required preconditions and required triggering conditions for operations, so that the resulting operations establish the goals. The process is iterative, is able to deal with safety goals and particular kinds of liveness goals, and is based on the use of interpolation and SAT solving

Expression of Distinct Desmocollin Isoforms in Human Epidermis

Previous evidence suggested the presence of two distinct desmocollin isoforms in human epidermis. These isoforms have now been distinguished at the protein level using monoclonal and polyclonal antibodies against N-terminal fragments of desmosomal glycoprotein (DG) IV/V isolated from plantar callus and antibodies against a fusion protein containing the extracellular domain of DGII/III. Immune blotting of glycoprotein fractions from whole epidermis, plantar callus, psoriatic scales and cultured keratinocytes showed that intact DGIV/V and its proteolytic fragments consistently migrated faster than DGII/III during SDS-PAGE. The apparent Mr difference between the two isoforms was in the range 2-5 kD. DGIV/V was the predominant species in epidermal tissue but was much less prominent in cultured cells by immune-blotting and immune precipitation. This is consistent with the differentiation-related expression of desmocollins revealed by immunofluorescence. DGIV/V was strongly expressed in the upper spinous/granular layer of the epidermis whereas DGII/III was more prominent in the basal layers of he tissue. The DGIV/V monoclonal (LH50) recognized an N-terminal, Ca++-sensitive epitope, because its staining of unfixed epidermal tissue was makedly influenced by Ca++ levels. Ca++ inhibition was observed at concentrations as low as 50 μM, suggesting its possible physiologic significance. Ca++ inhibition of LH50 binding was also observed in an enzyme-linked immunosorbent assay system using denatured glycoproteins although higher concentrations were required. It remains to be seen whether direct effects of Ca++ on desmocollin conformation are involved in the regulations of keratinization by extracellular Ca++

Surviving Supergentrification in Inner City Sydney: Adaptive Spaces and Makeshift Economies of Cultural Production

Artists and creative workers have long been recognized as playing an important role in gentrification, being often portrayed as forerunners of urban change and displacement in former industrial and working-class suburbs of ‘post-Fordist’ cities. However, as is well represented by recent research, the relationship between the arts, gentrification and displacement has been called into question. The purpose of this article, which draws on 30 case studies of creative spaces in Sydney's inner suburbs, is to chart some of the strategies of spatial adaptation and makeshift economies of solidarity that cultural workers adopt in order to keep living and working in areas of ‘supergentrification’. We document how cultural infrastructure is transformed by the gentrification process and argue that these alterations are critical to the survival of arts and culture in the city. Such makeshift economies contribute, in a practical way, to preserving the diversity that gentrification is sometimes deemed to destroy or displace. While the survival of creative spaces is a much less researched phenomenon than other forms of resistance or displacement, we suggest that it has important consequences for both research and policy decisions around gentrification, infrastructural development and urban cultural economies

Probing the Dawn of Galaxies at z~9-12: New Constraints from HUDF12/XDF and CANDELS Data

We present a comprehensive analysis of z>8 galaxies based on ultra-deep WFC3/IR data. We constrain the evolution of the UV luminosity function (LF) and luminosity densities from z~11 to z~8 by exploiting all the WFC3/IR data over the Hubble Ultra-Deep Field from the HUDF09 and the new HUDF12 program, in addition to the HUDF09 parallel field data, as well as wider area WFC3/IR imaging over GOODS-South. Galaxies are selected based on the Lyman Break Technique in three samples centered around z~9, z~10 and z~11, with seven z~9 galaxy candidates, and one each at z~10 and z~11. We confirm a new z~10 candidate (with z=9.8+-0.6) that was not convincingly identified in our first z~10 sample. The deeper data over the HUDF confirms all our previous z>~7.5 candidates as genuine high-redshift candidates, and extends our samples to higher redshift and fainter limits (H_160~29.8 mag). We perform one of the first estimates of the z~9 UV LF and improve our previous constraints at z~10. Extrapolating the lower redshift UV LF evolution should have revealed 17 z~9 and 9 z~10 sources, i.e., a factor ~3x and 9x larger than observed. The inferred star-formation rate density (SFRD) in galaxies above 0.7 M_sun/yr decreases by 0.6+-0.2 dex from z~8 to z~9, in good agreement with previous estimates. The low number of sources found at z>8 is consistent with a very rapid build-up of galaxies across z~10 to z~8. From a combination of all current measurements, we find a best estimate of a factor 10x decrease in the SFRD from z~8 to z~10, following (1+z)^(-11.4+-3.1). Our measurements thus confirm our previous finding of an accelerated evolution beyond z~8, and signify a rapid build-up of galaxies with M_UV<-17.7 within only ~200 Myr from z~10 to z~8, in the heart of cosmic reionization.Comment: 21 pages, 13 figures, 6 tables; submitted to Ap

Mass-Selection and the Evolution of the Morphology-Density Relation from z=0.8 to z=0

We examined the morphology-density relations for galaxy samples selected by luminosity and by mass in each of five massive X-ray clusters from z=0.023 to 0.83 for 674 spectroscopically-confirmed members. Rest-frame optical colors and visual morphologies were obtained primarily from Hubble Space Telescope images. Morphology-density relations (MDR) are derived in each cluster from a complete, luminosity-selected sample of 452 galaxies with a magnitude limit M_V < M^{*}_{V} + 1. The change in the early-type fraction with redshift matches previous work for massive clusters of galaxies. We performed a similar analysis, deriving MDRs for complete, mass-selected samples of 441 galaxies with a mass-limit of 10^{10.6} M_{\sun}. Our mass limit includes faint objects, the equivalent of =~1 mag below L^{*} for the red cluster galaxies, and encompasses =~70% of the stellar mass in cluster galaxies. The MDRs in the mass-selected sample at densities of Sigma > 50 galaxies Mpc^{-2} are similar to those in the luminosity-selected sample but show larger early-type fractions. However, the trend with redshift in the fraction of elliptical and S0 galaxies with masses > 10^{10.6} M_{\sun} differs significantly between the mass- and luminosity-selected samples. The clear trend seen in the early-type fraction from z=0 to z=~ 0.8 is not found in mass-selected samples. The early-type galaxy fraction changes much less, and is consistent with being constant at 92% +/- 4% at \Sigma> 500 galaxies Mpc^{-2} and 83 +/- 3% at 50 < \Sigma < 500 galaxies Mpc^{-2}. This suggests that galaxies of mass lower than > 10^{10.6} M_{\sun} play a significant role in the evolution of the early-type fraction in luminosity-selected samples. (Abstract abridged)Comment: 18 pages in emulate ApJ format, with 10 color figures, Accepted to ApJ. Version updated to reflect published version, includes new references and a correction to table