Three-dimensional physics and the pressure of hot QCD

We update Monte Carlo simulations of the three-dimensional SU(3) + adjoint Higgs theory, by extrapolating carefully to the infinite volume and continuum limits, in order to estimate the contribution of the infrared modes to the pressure of hot QCD. The sum of infrared contributions beyond the known 4-loop order turns out to be a smooth function, of a reasonable magnitude and specific sign. Unfortunately, adding this function to the known 4-loop terms does not improve the match to four-dimensional lattice data, in spite of the fact that other quantities, such as correlation lengths, spatial string tension, or quark number susceptibilities, work well within the same setup. We outline possible ways to reduce the mismatch.Comment: 14 page

Equation of state in 2+1 flavor QCD with improved Wilson quarks by the fixed scale approach

We study the equation of state in 2+1 flavor QCD with nonperturbatively improved Wilson quarks coupled with the RG-improved Iwasaki glue. We apply the $T$-integration method to nonperturbatively calculate the equation of state by the fixed-scale approach. With the fixed-scale approach, we can purely vary the temperature on a line of constant physics without changing the system size and renormalization constants. Unlike the conventional fixed-$N_t$ approach, it is easy to keep scaling violations small at low temperature in the fixed scale approach. We study 2+1 flavor QCD at light quark mass corresponding to $m_\pi/m_\rho \simeq 0.63$, while the strange quark mass is chosen around the physical point. Although the light quark masses are heavier than the physical values yet, our equation of state is roughly consistent with recent results with highly improved staggered quarks at large $N_t$.Comment: 14 pages, 12 figures, v2: Table I and Figure 3 are corrected, reference updated. Main discussions and conclusions are unchanged, v3: version to appear in PRD, v4: reference adde

An effective thermodynamic potential from the instanton with Polyakov-loop contributions

We derive an effective thermodynamic potential (Omega_eff) at finite temperature (T>0) and zero quark-chemical potential (mu_R=0), using the singular-gauge instanton solution and Matsubara formula for N_c=3 and N_f=2 in the chiral limit. The momentum-dependent constituent-quark mass is also obtained as a function of T, employing the Harrington-Shepard caloron solution in the large-N_c limit. In addition, we take into account the imaginary quark chemical potential mu_I = A_4, translated as the traced Polayakov-loop (Phi) as an order parameter for the Z(N_c) symmsetry, characterizing the confinement (intact) and deconfinement (spontaneously broken) phases. As a result, we observe the crossover of the chiral (chi) order parameter sigma^2 and Phi. It also turns out that the critical temperature for the deconfinment phase transition, T^Z_c is lowered by about (5-10)% in comparison to the case with a constant constituent-quark mass. This behavior can be understood by considerable effects from the partial chiral restoration and nontrivial QCD vacuum on Phi. Numerical calculations show that the crossover transitions occur at (T^chi_c,T^Z_c) ~ (216,227) MeV.Comment: 15 pages, 7 figure

Molecular Line Observations of Carbon-Chain-Producing Regions L1495B and L1521B

We present the first comprehensive study on physical and chemical properties of quiescent starless cores L1495B and L1521B, which are known to be rich in carbon-chain molecules like the cyanopolyyne peak of TMC-1 and L1521E. We have detected radio spectral lines of various carbon-chain molecules such as CCS, C$_{3}$S, C$_{4}$H, HC$_{3}$N, and HC$_{5}$N. On the other hand, the NH$_{3}$ lines are weak and the N$_{2}$H$^{+}$ lines are not detected. According to our mapping observations of the HC$_{3}$N, CCS, and C$_{3}$S lines, the dense cores in L1495B and L1521B are compact with the radius of 0.063 and 0.044 pc, respectively, and have a simple elliptical structure. The distributions of CCS seem to be different from those of well-studied starless cores, L1498 and L1544, where the distribution of CCS shows a shell-like structure. Since the H$^{13}$CO$^{+}$, HN$^{13}$C, and C$^{34}$S lines are detected in L1495B and L1521B, the densities of these cores are high enough to excite the NH$_{3}$ and N$_{2}$H$^{+}$ lines. Therefore, the abundances of NH$_{3}$ and N$_{2}$H$^{+}$ relative to carbon-chain molecules are apparently deficient, as observed in L1521E. We found that longer carbon-chain molecules such as HC$_{5}$N and C$_{4}$H are more abundant in TMC-1 than L1495B and L1521B, while those of sulfur-bearing molecules such as C$^{34}$S, CCS, and C$_{3}$S are comparable. Both distributions and abundances of the observed molecules of L1495B and L1521B are quite similar to those of L1521E, strongly suggesting that L1495B and L1521B is in a very early stage of physical and chemical evolution.Comment: 19 pages, 6 figures, accepted to The Astrophysical Journa

Design and Operation of 1000-fold Voltage Multiplier based on Double-flux-quantum Amplifier

AbstractRapid-single-flux-quantum digital-to-analogue converters (RSFQ-DACs) are now under development for ac voltage standard applications. The voltage multiplier (VM), which precisely amplifies the input voltage, is a key component for RSFQ-DACs. Because the amount of bias current for a conventional VM increases in proportion to its multiplication factor, we have been looking for a VM device which is operated on a different principle. In this paper, we report our design of a 1000-fold VM comprising double flux quantum amplifiers (DFQAs) of which the amount of bias current is independent of its multiplication factor. Test circuits were fabricated using a 2.5 kA/cm2 Nb process. We confirm that the experimental results demonstrate the 1000-fold operation up to 13.2 GHz input SFQ pulse repetition frequency

Self-similar solution of fast magnetic reconnection: Semi-analytic study of inflow region

An evolutionary process of the fast magnetic reconnection in ``free space'' which is free from any influence of outer circumstance has been studied semi-analytically, and a self-similarly expanding solution has been obtained. The semi-analytic solution is consistent with the results of our numerical simulations performed in our previous paper (see Nitta et al. 2001). This semi-analytic study confirms the existence of self-similar growth. On the other hand, the numerical study by time dependent computer simulation clarifies the stability of the self-similar growth with respect to any MHD mode. These results confirm the stable self-similar evolution of the fast magnetic reconnection system.Comment: 15 pages, 7 figure

Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease.

ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing neuroinflammation.MethodsTo determine if KCa3.1 is relevant to AD, we tested if treating cultured microglia or hippocampal slices with Aβ oligomer (AβO) activated KCa3.1 in microglia, and if microglial KCa3.1 was upregulated in 5xFAD mice and in human AD brains. The expression/activity of KCa3.1 was examined by qPCR, Western blotting, immunohistochemistry, and whole-cell patch-clamp. To investigate the role of KCa3.1 in AD pathology, we resynthesized senicapoc, a clinically tested KCa3.1 blocker, and determined its pharmacokinetic properties and its effect on microglial activation, Aβ deposition and hippocampal long-term potentiation (hLTP) in 5xFAD mice.ResultsWe found markedly enhanced microglial KCa3.1 expression/activity in brains of both 5xFAD mice and AD patients. In hippocampal slices, microglial KCa3.1 expression/activity was increased by AβO treatment, and its inhibition diminished the proinflammatory and hLTP-impairing activities of AβO. Senicapoc exhibited excellent brain penetrance and oral availability, and in 5xFAD mice, reduced neuroinflammation, decreased cerebral amyloid load, and enhanced hippocampal neuronal plasticity.InterpretationOur results prompt us to propose repurposing senicapoc for AD clinical trials, as senicapoc has excellent pharmacological properties and was safe and well-tolerated in a prior phase-3 clinical trial for sickle cell anemia. Such repurposing has the potential to expedite the urgently needed new drug discovery for AD

Magnetic and electric contributions to the energy loss in a dynamical QCD medium

The computation of radiative energy loss in a finite size QCD medium with dynamical constituents is a key ingredient for obtaining reliable predictions for jet quenching in ultra-relativistic heavy ion collisions. It was previously shown that energy loss in dynamical QCD medium is significantly higher compared to static QCD medium. To understand this difference, we here analyze magnetic and electric contributions to energy loss in dynamical QCD medium. We find that the significantly higher energy loss in the dynamical case is entirely due to appearance of magnetic contribution in the dynamical medium. While for asymptotically high energies, the energy loss in static and dynamical medium approach the same value, we find that the physical origin of the energy loss in these two cases is different.Comment: 6 pages, 4 figure