Uso de Sikadur32 sobre juntas frías para evaluar incidencia en la resistencia a la compresión del concreto f´c 210kg/cm², Bagua Grande

Esta investigación tiene como objetivo general evaluar el uso del Sikadur32 en juntas frías para determinar su incidencia en la resistencia a la compresión de concreto f´c 210 kg/cm², Bagua Grande. Una unión interfacial robusta entre los elementos de concreto es un requisito esencial para garantizar la eficacia de componentes de concreto con otros del mismo material (columna-columna, vigacolumna, losa-viga, etc.). Se probó edades de 2, 4 y 6 horas de diferencia entre el concreto viejo y el nuevo sobre testigos cilíndricos que fueron ensayados a los 7, 14 y 21 días. En los resultados se demostró que a los 21 días se aproxima a los 270 kg/cm², es decir, la aplicación del epóxico representa una mejora del 35% de los resultados son aditivo en las juntas frías. Se concluye que, de los especímenes ensayados a los 21 días, para cada una de las edades de las juntas frías es concluyente que los resultados de la junta de tipo horizontal con la aplicación del aditivo supera al demás tipo de junta, ya que se ha obtenido mejoras de hasta el 26%. Le sigue en valores los de la junta de tipo diagonal

Therapeutic Response After Immunosuppressive Drug Prescription in Non-infectious Uveitis: A Survival Analysis

Immunosuppressive drugs; Response to therapyMedicaments immunosupressors; Resposta al tractamentMedicamentos inmunosupresores; Respuesta al tratamientoIntroduction To identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU). Methods This longitudinal retrospective cohort study included patients from the Hospital Clinico San Carlos Uveitis Clinic diagnosed with NIU from 1992 to 2016. Subjects were followed up from ISD prescription until the achievement of good therapeutic response (GTR), ISD treatment change, or up to 12 months. GTR was defined as the complete resolution of the eye inflammatory manifestations with a corticosteroid dose ≤ 10 or ≤ 5 mg per day of prednisone or equivalent (GTR10 and GTR5, respectively) maintained for at least 28 days. Kaplan–Meier curves were estimated for GTR. Demographic, clinical, and treatment-related factors were analyzed using Cox robust regression. Results A total of 73 patients (100 episodes of ISD prescription) were analyzed. In 44 and 41 episodes, GTR10 and GTR5 were achieved, respectively. A lower hazard for both GTRs was associated with uveitic macular edema at prescription and with a higher “highest oral corticosteroid dose prescribed in the year before ISD prescription”. GTR10 was higher if cyclosporine was prescribed (compared to other ISDs), and if a higher number of ISDs had been previously prescribed. GTR5 hazard was lower for patients with posterior uveitis or if the ISDs were prescribed before 2008, and higher if periocular corticosteroids had been administered before ISD prescription, or if the duration of the posterior segment activity was shorter. Conclusions Factors associated with GTR to ISDs may help to identify patients with NIUs who could benefit from a thorough follow-up.This work was supported by the Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain [ICI19/00020; PI20/01221; RD21/002/0001]. The sponsor or funding organization had no role in the design or conduct of this research. The journal’s Rapid Service Fee was funded by the institution employing the senior author of the manuscript (Fundación Biomédica del Hospital Clínico San Carlos)

Modelo prolab: Paykuna, una propuesta sostenible para mejorar la calidad de vida de las madres de familia del distrito de Pucusana

De acuerdo a lo que expone Casas (2020), la pobreza y la desigualdad son atributos los cuales se encuentran estrechamente vinculados; ya que la existencia de pobreza es un factor de que exista desigualdad. En esa esa línea, en el Perú las personas de escasos recursos tienen menores posibilidades de superar las brechas de pobreza ya que no desigualdad de oportunidades Esto se torna más trágico en el caso de las mujeres en situación de pobreza o pobreza extrema con hijos menores de tres años; ya que, al tener la carga familiar, se le restan las escasas oportunidades laborales que podría obtener para generar ingresos. Dicha situación genera dos grandes problemas; en primer lugar, los hijos de las madres no lograrán acceso a una educación de calidad, servicios de salud decentes y una dieta alimenticia balanceada; en segundo lugar, la madre no podrá desarrollarse personalmente ni cumplir sus objetivos propios, generando una frustración personal. En base a lo anterior, la presente tesis propone incrementar la oferta laboral formal mediante la creación de una empresa que pueda instalarse en una zona cercana a las viviendas de las madres; cuyos perfiles de puestos posean actividades operativas que no requieran de mayor instrucción; y, que brinde facilidades para el cuidado de sus menores hijos. Por ello, se expone la creación de la empresa Paykuna, palabra del quechua cuyo nombre significa “ellas”; la cual tiene como core business la crianza, transformación y comercialización de cuyes en diversas presentaciones (cuy entero, cuy trozado, cuy empanizado y cuy aderezado), en el distrito de Pucusana – Lima. Adicionalmente, la propuesta está alineada a los Objetivos de Desarrollo Humano (ODS) 8 y 10 ya que impacta en la generación de empleo formal para las madres de familia en situación de pobreza e incrementa los ingresos y accesos a servicios de salud. Finalmente, para definir el modelo de negocio, se han formulado distintas hipótesis las cuales evidencian la deseabilidad de las presentaciones; con una demanda aproximada de 4,621,231 personas en Lima Metropolitana. Asimismo, a nivel de viabilidad, se ha identificado una TIR de 68.17%, WACC de 10.878%; un valor actual neto (FCE) de S/3’023,738.3; y, un valor actual (FCF) de S/3’052,732.4. Por otro lado, el resultado final del proyecto arroja un VAN social de S/ 3.3 MM equivalente a USD 885,635 por lo que se puede determinar que existe mercado para posicionar la empresa y que el impacto en la sociedad sí es significativo.According to Casas (2020) poverty and inequality are attributes which are closely linked; since the existence of poverty is a factor of the existence of inequality. In Peru low-income people have fewer possibilities of overcoming the poverty gaps, since they do not have inequality of opportunities. This becomes more tragic in the case of women living in poverty or extreme poverty with children under three years of age; since, having the family burden, the few job opportunities that she could obtain to generate income are subtracted. This situation generates two big problems: First, the children of the mothers will not have access to quality education, decent health services and a balanced diet; and, the mother will not be able to develop personally or meet her own goals, generating personal frustration. Based on the above, this thesis proposes to increase the formal job offer by creating a company that can be installed in an area close to the mothers' homes; whose job profiles have operational activities that do not require further instruction; and that provides facilities for the care of their minor children. For this reason, the creation of the company Paykuna, a Quechua word used to refer to women in the third person, is being considered; which has as its core business the breeding, transformation and commercialization of guinea pigs in various presentations (whole guinea pig, chopped guinea pig, breaded guinea pig and seasoned guinea pig), in the district of Pucusana - Lima. Additionally, the proposal is aligned with Human Development Goals (SDGs) 8 and 10 since it impacts the generation of formal employment for mothers in poverty and increases income and access to health services. Finally, in order to define the business model, differents hypotheses have been formulated which result in the desirability of the presentations; with an approximate demand of 4,621,231 people in Metropolitan Lima. Likewise, at the feasibility level, an IRR of 68.17%, WACC of 10.878% has been identified; a net present value (FCE) of S/3'023,738.3; and a current value (FCF) of S/3'052,732.4. On the other hand, the result of the project shows a social NPV of S/ 3.3 MM equivalent to USD 885,635, therefore it can be determined that there is a market to position the company and that the impact on society is significant

High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

Objective. To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthropometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative RealTime PCR assays. Results. Anthropometric and biochemical parameters were statistically higher in overweigth/ obese children (OW/O) than in lean (NW), Increased TNF-α levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF-α. This is the first study that shows a relation between Firmicute abundance and TNF-α serum concentration in obese children

MADRID (Marco Activo De Recursos de Innovación Docente). Madrid - Comunidad

Fac. de Ciencias BiológicasFALSEsubmitte

Marco activo de recursos de innovación docente: Madrid

Una guía de espacios e instituciones para actividades educativas complementarias en enseñanza secundaria y Formación Profesional

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis

Alzheimer’s disease (AD) is the most common form of dementia, currently affecting 35 million people worldwide. Apolipoprotein E (APOE) ε4 allele is the major risk factor for sporadic, late-onset AD (LOAD), which comprises over 95% of AD cases, increasing the risk of AD 4-12 fold. Despite this, the role of APOE in AD pathogenesis is still a mystery. Aiming for a better understanding of APOE-specific effects, the ADAPTED consortium analysed and integrated publicly available data of multiple OMICS technologies from both plasma and brain stratified by APOE haplotype (APOE2, APOE3 and APOE4). Combining genome-wide association studies (GWAS) with differential mRNA and protein expression analyses and single-nuclei transcriptomics, we identified genes and pathways contributing to AD in both APOE dependent and independent fashion. Interestingly, we characterised a set of biomarkers showing plasma and brain consistent protein profiles and opposite trends in APOE2 and APOE4 AD cases that could constitute screening tools for a disease that lacks specific blood biomarkers. Beside the identification of APOE-specific signatures, our findings advocate that this novel approach, based on the concordance across OMIC layers and tissues, is an effective strategy for overcoming the limitations of often underpowered single-OMICS studies

Jornada de Grandes infraestructuras europeas de Ciencias Sociales y Humanidades en el CSIC: DARIAH y CLARÍN en el horizonte (11 de mayo de 2023)

Peer reviewe

Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía

El PIMCD “Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía” constituye la cuarta edición de un PIMCD que ha recibido financiación en las últimas convocatorias de PIMCD UCM, de los que se han derivado actividades de formación para estudiantes de Grado, Máster y Doctorado y al menos 3 publicaciones colectivas publicadas por Ediciones Complutense, Siglo XXI y Palgrave McMillan