Reseña histórica de la Universidad de Salamanca

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

Iliotibial band friction syndrome in triathletes: A systematic review

RESUMEN: Introducción: El síndrome de fricción de la banda iliotibial (SFBIT) es una lesión común en corredores y ciclistas de larga distancia que supone una lesión de la parte lateral externa de la rodilla, que se produce por compresión contra una capa de grasa altamente inervada entre la cintilla y el epicóndilo. Es importante diferenciar la lesión de las distintas patologías que producen dolor en la zona lateral de la rodilla como la condropatía rotuliana, el menisco externo, el ligamento lateral o distintas ramas nerviosas como el ciático poplíteo externo. Objetivo: El propósito de este artículo es, dentro de lo que permita la literatura publicada, la realización de una revisión sistemática de los diferentes tratamientos del SFBIT. Metodología: Se realizó una búsqueda en las bases de datos Cochrane, PEDro y Medline, a través de Pubmed para identificar artículos referentes a la banda iliotibial y su patología. Para la valoración de los estudios seleccionados se emplearon la escala PEDro y la escala MINCIR. Resultados: Con respecto al tratamiento, las cinco intervenciones seleccionadas incluyeron el uso de AINEs, el empleo de corticoesteroides, el masaje de fricción transversa profunda, la bursectomía y la prevención mediante una plantilla personalizada. Discusión: La revisión posee una calidad metodológica limitada para sugerir que estos tratamientos ofrecen algún beneficio significante en el tratamiento de ITBFS. Los futuros estudios necesitarán mejorar metodológicamente incluyendo en los estudios grupos control y alguna clase de ciegos para mejorar la metodología. Además deberá investigar más sobre los tratamientos quirúrgicos para los casos crónicos de SFBIT.ABSTRACT: Introduction: Iliotibial band friction syndrome (ITBFS) is a common injury in long distance runners and cyclists representing a lesion of the outer side of the knee, which is produced by compression against a layer of highly innervated fat between tract and the epicondyle. It is important to differentiate the lesion from different diseases which cause pain in the lateral side of the knee like patellar chondropathy, the lateral meniscus, or different lateral nerve branches as the external popliteal sciatic ligament. Objective: The purpose of this paper is, as far as allow the published literature, conduct a systematic review of the different treatments in ITBFS. Methods: A search was made on the data bases of Cochrane, PEDro and Medline through PubMed to identify articles about the iliotibial band and its pathology. For the assessment of the selected studies MINCIR and the PEDro scales were used. Results: With regard to treatment, the five selected interventions included in the systematic review were the use of NSAIDs, corticosteroid use, the deep transverse friction massage, bursectomy and prevention using a custom foot orthotic. Discussion: The review has a limited methodological quality, which suggest that these treatments don’t offer a significant benefit in the treatment of ITBFS. Future studies will need to improve methodological quality including control groups and some kind of blind to improve the methodology. You should also investigate more about surgical treatments for chronic cases of ITBFS.Grado en Fisioterapi

Neurosonology: An Update

Recent technological advances in diagnostic ultrasound have resulted in the development of high-resolution, portable real-time scanners. In neurological ultrasound, these devices have been particularly useful for detecting intracranial hemorrhage in premature infants. Sonography is now being used during neurosurgical procedures to help in localizing masses for resection and biopsy, as well as in the placement of shunt catheters. The applications of neurosonology and our experience with intraoperative neurosonology are reported in this review

Discursos pronunciados en la Real Academia de Ciencias Morales y Políticas en la recepción pública del señor don Santiago Diego Madrazo en 18 de diciembre de 1864

Contestación de Manuel Colmeir

Multiple particle tracking analysis in isolated nuclei reveals the mechanical phenotype of leukemia cells.

The nucleus is fundamentally composed by lamina and nuclear membranes that enclose the chromatin, nucleoskeletal components and suspending nucleoplasm. The functional connections of this network integrate external stimuli into cell signals, including physical forces to mechanical responses of the nucleus. Canonically, the morphological characteristics of the nucleus, as shape and size, have served for pathologists to stratify and diagnose cancer patients; however, novel biophysical techniques must exploit physical parameters to improve cancer diagnosis. By using multiple particle tracking (MPT) technique on chromatin granules, we designed a SURF (Speeded Up Robust Features)-based algorithm to study the mechanical properties of isolated nuclei and in living cells. We have determined the apparent shear stiffness, viscosity and optical density of the nucleus, and how the chromatin structure influences on these biophysical values. Moreover, we used our MPT-SURF analysis to study the apparent mechanical properties of isolated nuclei from patients of acute lymphoblastic leukemia. We found that leukemia cells exhibited mechanical differences compared to normal lymphocytes. Interestingly, isolated nuclei from high-risk leukemia cells showed increased viscosity than their counterparts from normal lymphocytes, whilst nuclei from relapsed-patient's cells presented higher density than those from normal lymphocytes or standard- and high-risk leukemia cells. Taken together, here we presented how MPT-SURF analysis of nuclear chromatin granules defines nuclear mechanical phenotypic features, which might be clinically relevant.post-print1994 K

Cost analysis of chronic obstructive pulmonary disease (COPD): a systematic review

Background Chronic Obstructive Pulmonary Disease (COPD) is a treatable disease with a high prevalence, and high morbidity associated with significant socioeconomic costs. Objective To carry out a systematic review of the literature to analyze the main cost studies associated with COPD, in order to determine the main factors that influence the costs of the disease. Methods Searches were conducted in PubMed, SCOPUS and Web of Science databases for cost studies on COPD published in English, between the years 2015 and 2020. The search terms were ?COPD? OR ?pulmonary disease, chronic obstructive?, ?cost*? OR ?cost of illness?, ?economic impact? AND ?burden of disease?. The inclusion criteria included the identification of reported cost of the disease, economic burden, medical care expenses or use resources for COPD, the methodology used, data sources, and variables studied. Results 18 publications were analyzed: 17 included direct health costs, 6 included direct non-medical costs, 12 analyzed indirect costs and two reported intangible costs. Most of the studies reported data for developed and European countries, with direct costs being the most studied. Trends were observed in multiple studies of direct and healthcare costs for European countries measured by patient and year, where the higher costs were associated with more severe COPD and a frequent history of exacerbations. The highest costs reported corresponded to hospitalizations and the associated pharmacological treatment. The importance of the loss of productivity and premature retirement within the profile of the COPD patient was also highlighted as the main generator of indirect costs of the disease. Conclusion COPD generates substantial costs for the health system, mainly related to moderate to severe stages and the exacerbations and complications entailed. It is important to strengthen health systems with monitoring, evaluation and health education models that allow these patients to remain stable to avoid decompensation and subsequent hospitalizations

E-cadherin expression is associated with somatostatin analogue response in acromegaly

Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs) represent the primary medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy after unsuccessful pituitary surgery. However, a considerable proportion of patients do not adequately respond to SSAs treatment, and therefore, there is an urgent need to identify biomarkers predictors of response to SSAs. The aim of this study was to examine E‐cadherin expression by immunohistochemistry in fifty‐five GH‐producing pituitary tumours and determine the potential association with response to SSAs as well as other clinical and histopathological features. Acromegaly patients with tumours expressing low E‐cadherin levels exhibit a worse response to SSAs. E‐cadherin levels are associated with GH‐producing tumour histological subtypes. Our results indicate that the immunohistochemical detection of E‐cadherin might be useful in categorizing acromegaly patients based on the response to SSAs.ISCIII‐Subdirección General de Evaluación y Fomento de la Investigación PI13/02043 PI16/00175FEDER PI13/02043 PI16/00175Junta de Andalucía A‐0023‐2015 A‐0003‐2016 CTS‐1406 BIO‐0139Andalusian Ministry of Health C‐0015‐2014CIBERobn PI13/ 02043 PI16/0017

Compress sensing algorithm for estimation of signals in sensor networks

ARTICULO DE INVESTIGACION IDEXADO EN JCR CON FACTOR DE IMPACTO 2.4In this research, we present a data recovery scheme for wireless sensor networks. In some sensor networks, each node must be able to recover the complete information of the network, which leads to the problem of the high cost of energy in communication and storage of information. We proposed a modified gossip algorithm for acquire distributed measurements and communicate the information across all nodes of the network using compressive sampling and Gossip algorithms to compact the data to be stored and transmitted through a network. The experimental results on synthetic data show that the proposed method reconstruct better the signal and in less iterations than with a similar method using a thresholding algorithm

Demographic variables associated with Covid-19 mortality

Objectives: Covid-19 is a betacoronavirus that was initially transmitted to humans from an animal host. It enters the cell by binding its protein S with angiotensin-converted enzyme receptors. It is transmitted through direct contact and respiratory drops. The most affected population so far are older adults and people with chronic conditions. The objective of this research is to analyze the possible association between the structure of the population pyramid, the Gross Domestic Product, the type of isolation and screening used to detect Covid-19 in the countries with the highest and lowest mortality from this disease.Design and Methods: Some variables take part in the Covid-19 mortality worldwide, such as the population structure, expressed in the population pyramid by country, the type of isolation adopted in each nation, the Gross Domestic Product (GDP) as well as the type of screening that is implemented in the different countries analyzed.Results: After analyzing the mean difference in the countries with a regressive and progressive population pyramid, an association was identified between the regressive population pyramid structure and the higher mortality rate (p<0.001).Conclusions: The countries with a progressive population pyramid are the most benefited by making their population more screened since the mortality rate decreases significantly compared to the countries with less attribution (p<0.036)