Letter from Walter Maddock to Senator Langer Regarding James Hall\u27s Letter Regarding FHA Interest, February 28, 1947

This letter dated February 28, 1947, from Walter Maddock to United States Senator William Langer, responds to Langer\u27s previous letter regarding James Hall\u27s inquiry about waiving FHA interest for people in Elbowoods, North Dakota. Maddock notes that he has been in communication with Hall and the Tribal Council on this matter, and Maddock says that due to complicating factors a decision cannot be made at this time. See Also: Letter from Senator Langer to Walter Maddock Regarding James Hall\u27s Letter Regarding FHA Interest, January 27, 1947https://commons.und.edu/langer-papers/1486/thumbnail.jp

Comparison of the emissions of current expendable launch vehicles and future spaceplanes

This paper compares the environmental impact of two types of launch vehicles, an expendable vertical launcher (Delta IV) and a conceptual SSTO spaceplane. A realistic trajectory for the spaceplane is generated using a multiple-shooting trajectory optimisation method, which integrates physical models and generates an optimal control law minimising the fuel consumption and the emissions of the flight. These were compared with the emissions from a standard Delta IV trajectory. The launch was to a 200 km circular LEO at 27.5° inclination. The chemical investigated is H2O, which contributes to the depletion of the ozone layer in the stratosphere. The study shows that for the ascent trajectory the spaceplane produces a total of 5.0143 x 105 kg of H2O, compared with 2.24 x 105 kg for the Delta IV. The spaceplane has a peak production altitude in the sensitive lower stratosphere, compared to the much lower peak production altitude of the Delta IV

Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis.

Evidence has been accumulating for an immune-based component to the etiology of psychotic disorders. Advancements in diffusion magnetic resonance imaging (MRI) have enabled estimation of extracellular free water (FW), a putative biomarker of neuroinflammation. Furthermore, inflammatory processes may be associated with altered brain levels of metabolites, such as glutathione (GSH). Consequently, we sought to test the hypotheses that FW is increased and associated with decreased GSH in patients with first-episode schizophrenia (SZ) compared with healthy controls (HC). SZ (n = 36) and HC (n = 40) subjects underwent a multi-shell diffusion MRI scan on a Siemens 3T scanner. 1H-MR spectroscopy data were acquired using a GSH-optimized MEGA-PRESS editing sequence and GSH/creatine ratios were calculated for DLPFC (SZ: n = 33, HC: n = 37) and visual cortex (SZ: n = 29, HC: n = 35) voxels. Symptoms and functioning were measured using the SANS, SAPS, BPRS, and GSF/GRF. SZ demonstrated significantly elevated FW in whole-brain gray (p = .001) but not white matter (p = .060). There was no significant difference between groups in GSH in either voxel. However, there was a significant negative correlation between DLPFC GSH and both whole-brain and DLPFC-specific gray matter FW in SZ (r = -.48 and -.47, respectively; both p < .05), while this relationship was nonsignificant in HC and in both groups in the visual cortex. These data illustrate an important relationship between a metabolite known to be important for immune function-GSH-and the diffusion extracellular FW measure, which provides additional support for these measures as neuroinflammatory biomarkers that could potentially provide tractable treatment targets to guide pharmacological intervention

Prehospital critical care is associated with increased survival in adult trauma patients in Scotland

Background Scotland has three prehospital critical care teams (PHCCTs) providing enhanced care support to a usually paramedic-delivered ambulance service. The effect of the PHCCTs on patient survival following trauma in Scotland is not currently known nationally. Methods National registry-based retrospective cohort study using 2011-2016 data from the Scottish Trauma Audit Group. 30-day mortality was compared between groups after multivariate analysis to account for confounding variables. Results Our data set comprised 17 157 patients, with a mean age of 54.7 years and 8206 (57.5%) of male gender. 2877 patients in the registry were excluded due to incomplete data on their level of prehospital care, leaving an eligible group of 14 280. 13 504 injured adults who received care from ambulance clinicians (paramedics or technicians) were compared with 776 whose care included input from a PHCCT. The median Injury Severity Score (ISS) across all eligible patients was 9; 3076 patients (21.5%) met the ISS>15 criterion for major trauma. Patients in the PHCCT cohort were statistically significantly (all p < 0.01) more likely to be male; be transported to a prospective Major Trauma Centre; have suffered major trauma; have suffered a severe head injury; be transported by air and be intubated prior to arrival in hospital. Following multivariate analysis, the OR for 30-day mortality for patients seen by a PHCCT was 0.56 (95% CI 0.36 to 0.86, p=0.01). Conclusion Prehospital care provided by a physician-led critical care team was associated with an increased chance of survival at 30 days when compared with care provided by ambulance clinicians

Life course socioeconomic position and DNA methylation age acceleration in mid-life

BACKGROUND: Ageing biomarkers can help us better understand how well-established socioeconomic position (SEP) disparities in ageing occur. A promising new set of DNAm methylation (DNAm)-based ageing biomarkers indicate through their age acceleration (AA) measures if biological ageing is slower or faster than chronological ageing. Few studies have investigated the association between SEP and DNAm AA. METHODS: We used linear regression to examine the sex-adjusted relationships between childhood social class, adult social class, intergenerational social class change, education and adult household earnings with first (Horvath AA and Hannum AA) and second generation (PhenoAge AA and GrimAge AA) DNAm AA markers using data from the MRC National Survey of Health and Development. RESULTS: In the first-generation biomarkers, there was little evidence of any associations with Horvath AA but associations of childhood social class and income with Hannum AA were observed. Strong associations were seen between greater disadvantage in childhood and adult SEP and greater AA in the second generation biomarkers. For example, those with fathers in an unskilled occupational social class in childhood had 3.6 years greater PhenoAge AA (95% CI 1.8 to 5.4) than those with fathers from a professional social class. Individuals without qualifications had higher AA compared with those with higher education (4.1 years greater GrimAge AA (95% CI 3.1 to 5.0)). CONCLUSION: Our findings highlight the importance of exposure to social disadvantage in childhood to the biological ageing process. The second generation clocks appear to be more sensitive to the accumulation of social disadvantage across the life course

Enhancing breadth of knowledge within multidisciplinary doctoral research: reflections from the Cambridge Generic Nutrition Training course for non-nutritionist postgraduates and professionals

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Increasing the Value of the Round and Sirloin Through Pre-Rigo Skeletal Separations

Thirty crossbred steers were utilized to explore and compare tenderness improvements in beef round and sirloin muscles resulting from various methods of pre-rigor skeletal separations. Animals were slaughtered according to industry procedures and at 60 min postmortem one of six treatments were randomly applied to each side: A) control, B) saw pelvis at the sirloin-round junction, C) separate the pelvic-femur joint, D) saw femur at mid-point, E) combination of B and C, and F) combination of B and D. After 48-h, the following muscles were excised from each side: semimembranosis (SM), biceps femoris (BF-R), semitendinosis (ST), and adductor (AD) from the round; vastus lateralis (VL) and rectus femoris (RF) from the knuckle; and gluteus medius (GM), biceps femoris (BF-S) and psoas major (PM) from the sirloin. Following a 10 d ageing period, samples were removed from each muscle to determine the effect of treatments on sarcomere length and Warner-Bratzler shear force. Sarcomere lengths differed between treatments for SM, AD, ST, GM, and PM. Treatment C resulted in longer sarcomeres than controls for SM, AD, and ST. All pre-rigor skeletal separation treatments yielded shorter sarcomeres for the PM as compared to controls. Warner-Bratzler shear force differed between treatments for RF, ST and PM. For RF, all treatments, except B, resulted in lower (P \u3c 0.05) shear values than for controls. Treatment F resulted in higher shear force values for the PM than controls (P \u3c 0.05). Also, treatments B, D, and F increased shear force of the ST relative to controls (P \u3c 0.05). Correlations between sarcomere length and shear force were found to be low and quite variable between muscles. In general, treatments increased sarcomere length of several muscles from the sirloin/round region, but had mixed effects on shear force values