Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease

The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of these diseases remains poorly understood. One pathway that these neurodegenerative diseases share is the accumulation of pathologic proteins which are not only harmful in their soluble form but may go on to form toxic aggregates. In many cases, a consensus has yet to be reached concerning the mechanism for protein aggregation. Therefore, the exploration of the roles of these proteins and their possible mechanisms, along with potential techniques for treatment, are more important than ever

Money and Taxes: The Relationship Between Financial Sector Development and Taxation

Requiring taxes to be paid in domestic money provides a legal tender basis for money demand and hence to the development of a financial system. In emerging markets, the level of taxation is a positive factor boosting financial development. At higher tax rates, however, taxation provides an incentive to reduce money demand and reduces the size of the financial sector. There is also evidence of re-switching in high-tax developed countries, where financial deepening increases with the tax rate. Such financial deepening represents a form of capital market repression, not unlike the growth-depressing effects of financial repression in many poor countries.Taxation; financial development; money demand; money multiplier; emerging markets

A perspective on the economics of natural gas decontrol

Natural gas ; Natural resources ; Energy policy

Derived Equivalences of K3 Surfaces and Twined Elliptic Genera

We use the unique canonically-twisted module over a certain distinguished super vertex operator algebra---the moonshine module for Conway's group---to attach a weak Jacobi form of weight zero and index one to any symplectic derived equivalence of a projective complex K3 surface that fixes a stability condition in the distinguished space identified by Bridgeland. According to work of Huybrechts, following Gaberdiel--Hohenegger--Volpato, any such derived equivalence determines a conjugacy class in Conway's group, the automorphism group of the Leech lattice. Conway's group acts naturally on the module we consider. In physics the data of a projective complex K3 surface together with a suitable stability condition determines a supersymmetric non-linear sigma model, and supersymmetry preserving automorphisms of such an object may be used to define twinings of the K3 elliptic genus. Our construction recovers the K3 sigma model twining genera precisely in all available examples. In particular, the identity symmetry recovers the usual K3 elliptic genus, and this signals a connection to Mathieu moonshine. A generalization of our construction recovers a number of the Jacobi forms arising in umbral moonshine. We demonstrate a concrete connection to supersymmetric non-linear K3 sigma models by establishing an isomorphism between the twisted module we consider and the vector space underlying a particular sigma model attached to a certain distinguished K3 surface.Comment: 62 pages including 7 pages of tables; updated references and minor editing in v.2; to appear in Research in the Mathematical Science

The Moonshine Module for Conway's Group

We exhibit an action of Conway's group---the automorphism group of the Leech lattice---on a distinguished super vertex operator algebra, and we prove that the associated graded trace functions are normalized principal moduli, all having vanishing constant terms in their Fourier expansion. Thus we construct the natural analogue of the Frenkel--Lepowsky--Meurman moonshine module for Conway's group. The super vertex operator algebra we consider admits a natural characterization, in direct analogy with that conjectured to hold for the moonshine module vertex operator algebra. It also admits a unique canonically-twisted module, and the action of the Conway group naturally extends. We prove a special case of generalized moonshine for the Conway group, by showing that the graded trace functions arising from its action on the canonically-twisted module are constant in the case of Leech lattice automorphisms with fixed points, and are principal moduli for genus zero groups otherwise.Comment: 54 pages including 11 pages of tables; minor revisions in v2, submitte

Confinement by Monopoles in the Positive Plaquette Model of SU(2) Lattice Gauge Theory

Confinement via 't Hooft-Mandelstam monopoles is studied for the positive plaquette model in SU(2) lattice gauge theory. Positive plaquette model configurations are projected into the maximum abelian gauge and the magnetic current extracted. The resulting magnetic current is used to compute monopole contributions to Wilson loops and extract a monopole contribution to the string tension. As was previously found for the Wilson action, the monopole contribution to the string tension agrees with the string tension calculated directly from the SU(2) links. The fact that the positive plaquette model suppresses Z2 monopoles and vortices is discussed.Comment: 8 pages, one Postscript figure, Latex, uses psfig files: posplaq.tex,posplaq.aux,pp_1_3.ps packaged with uufile

The New Open Forum: Social Media Use in Georgia Gubernatorial Elections

In 2018, Georgia saw one of the most contested elections in recent memory with Brian Kemp narrowly defeating Stacey Abrams. As a part of that election, social media would play a critical role in how campaigns are run. This thesis takes a look at previous literature on voter turnout and social media. This thesis asks: How did the campaigns use social media to spread their message, and in what stage of the election was social media most effective? To answer that question this thesis features a content analysis of Facebook posts and Tweets from the 2018 elections compared to posts in the 2014 elections to answer my question and to see how campaigning on social media has evolved since 2014. The results are that campaigns are more likely to post from the campaign trail and Get Out the Vote messages and during the final days of the general election campaign