Wolf, Canis lupus, Den Site Selection in the Rocky Mountains

Because mortality of Wolves, Canis lupus, is highest during the first six months of life, den site selection may affect reproductive success of Wolf populations. We studied fine-scale denning habitat selection (within 100 m of den site) by comparing field-measured characteristics of 22 dens in Idaho, Montana, and Alberta with 22 paired random contrast locations within pack home ranges. In order of importance, Wolves denned in areas with greater canopy cover, hiding cover, herbaceous ground cover, and woody debris, and were closer to water than paired random sites. Thus Wolves may select den sites for physical protection and available water. We also studied coarse-scale denning habitat selection by comparing 35 Wolf dens with 35 paired contrast locations in Idaho, Montana, and Wyoming with respect to six remotely-sensed variables (elevation, slope, coniferous forest cover, solar radiation, distance to water, and distance to roads). Although these variables did not differ (univariate P > 0.10) between den and contrast locations, a Mahalanobis-distance model using four remotely-sensed variables (slope, elevation, coniferous forest cover, and solar radiation) suggested > 85% of dens would occur in potential denning habitat occupying < 12% of the Wolf recovery areas in the northern Rocky Mountains. This model may be useful for identifying likely den locations in areas not yet occupied by Wolves. Wolf core use areas, including den areas, showed higher intensity of use throughout the year when compared to the entire territory

Comparison of Two Common Outpatient Preparations for Colonoscopy in Children and Youth

Colonoscopies are often performed in children for diagnostic and therapeutic purposes. Our study compared two bowel-cleansing solutions: sodium picosulphate, magnesium oxide, and citric acid (Pico-Salax) with liquid magnesium citrate as preparations for colonoscopy. A retrospective chart review of all patients seen in the Gastroenterology outpatient clinic and who underwent bowel cleansing in preparation for colonoscopy from February to December 2006 was undertaken. Thirty-two children received Pico-Salax and 36 received liquid magnesium citrate. The tolerability of both solutions was similar. Most children in both groups had liquid stools and complete colonoscopies. Bowel preparation for a colonoscopy can be successfully achieved using either Pico-Salax or liquid magnesium citrate

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European American MS patients and 419 ethnically matched controls, using next-generation sequencing. The DRB1*15:01~DQB1*06:02 haplotype was highly predisposing (odds ratio (OR) = 3.98; 95% confidence interval (CI) = 3-5.31; p-value (p) = 2.22E-16), as was DRB1*03:01~DQB1*02:01 (OR = 1.63; CI = 1.19-2.24; p = 1.41E-03). Hardy-Weinberg (HW) analysis in MS patients revealed a significant DRB1*03:01~DQB1*02:01 homozyote excess (15 observed; 8.6 expected; p = 0.016). The OR for this genotype (5.27; CI = 1.47-28.52; p = 0.0036) suggests a recessive MS risk model. Controls displayed no HW deviations. The C*03:04~B*40:01 haplotype (OR = 0.27; CI = 0.14-0.51; p = 6.76E-06) was highly protective for MS, especially in haplotypes with A*02:01 (OR = 0.15; CI = 0.04-0.45; p = 6.51E-05). By itself, A*02:01 is moderately protective, (OR = 0.69; CI = 0.54-0.87; p = 1.46E-03), and haplotypes of A*02:01 with the HLA-B Thr80 Bw4 variant (Bw4T) more so (OR = 0.53; CI = 0.35-0.78; p = 7.55E-04). Protective associations with the Bw4 KIR ligand resulted from linkage disequilibrium (LD) with DRB1*15:01, but the Bw4T variant was protective (OR = 0.64; CI = 0.49-0.82; p = 3.37-04) independent of LD with DRB1*15:01. The Bw4I variant was not associated with MS. Overall, we find specific class I HLA polymorphisms to be protective for MS, independent of the strong predisposition conferred by DRB1*15:01

Spinning Conformal Correlators

We develop the embedding formalism for conformal field theories, aimed at doing computations with symmetric traceless operators of arbitrary spin. We use an index-free notation where tensors are encoded by polynomials in auxiliary polarization vectors. The efficiency of the formalism is demonstrated by computing the tensor structures allowed in n-point conformal correlation functions of tensors operators. Constraints due to tensor conservation also take a simple form in this formalism. Finally, we obtain a perfect match between the number of independent tensor structures of conformal correlators in d dimensions and the number of independent structures in scattering amplitudes of spinning particles in (d+1)-dimensional Minkowski space.Comment: 46 pages, 3 figures; V2: references added; V3: tiny misprint corrected in (A.9

Medical Device Innovation: Prospective Solutions for an Ecosystem in Crisis Adding a Professional Society Perspective

Barriers to medical device innovation compromise timelines and costs from bench to bedside. Fragmented strategies by individual competitors are no longer sustainable. Pragmatically focused pre-competitive collaboration across stakeholders approaches innovation as an ecosystem. Desiloing experience and expertise encourages high-impact infrastructure efficiencies unique to pre-competitive constructs. Alignment of processes and objectives across the regulatory, reimbursement, clinical research, and clinical practice enterprises, with particular attention to the total product life cycle and continuous accrual of safety information, promotes more predictable equipoise for speed of access relative to residual safety concerns. Professional societies are well positioned to convene pre-competitive dialogue, facilitate alignment, and add perspective to equipoise within the innovation ecosystem

Calibration Changes to Terra MODIS Collection-5 Radiances for CERES Edition 4 Cloud Retrievals

Previous research has revealed inconsistencies between the Collection 5 (C5) calibrations of certain channels common to the Terra and Aqua MODerate-resolution Imaging Spectroradiometers (MODIS). To achieve consistency between the Terra and Aqua MODIS radiances used in the Clouds and the Earths Radiant Energy System (CERES) Edition 4 (Ed4) cloud property retrieval system, adjustments were developed and applied to the Terra C5 calibrations for channels 1-5, 7, 20, and 26. These calibration corrections were developed independently of those used for MODIS Collection 6 (C6) data, which became available after the CERES Ed4 processing had commenced. The comparisons demonstrate that the corrections applied to the Terra C5 data for CERES Edition 4 generally resulted in Terra- Aqua radiance consistency that is as good as or better than that of the C6 datasets. The C5 adjustments resulted in more consistent Aqua and Terra cloud property retrievals than seen in the previous CERES edition. Other calibration artifacts were found in one of the corrected channels and in some of the uncorrected thermal channels after Ed4 began. Where corrections were neither developed nor applied, some artifacts are likely to have been introduced into the Ed4 cloud property record. For example, the degradation in the Aqua MODIS 0.65- m channel in both the C5 and C6 datasets affects trends in cloud optical depth retrievals. Thus, despite the much-improved consistency achieved for the Terra and Aqua datasets in Ed4, the CERES Ed4 cloud property datasets should be used cautiously for cloud trend studies because of those remaining calibration artifacts

Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice

Objective. Retrospective studies have found that noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) exhibits highly indolent clinical behavior. We studied the clinical features of our patients with noninvasive EFVPTC tumors culled from a community endocrine surgical practice registry over the past four years. Methods. We interrogated the Memorial Center for Integrative Endocrine Surgery (MCIES) Registry for all recorded encapsulated follicular variant of papillary cancer pathologic diagnoses. We identified a subgroup of patients without capsular or vascular invasion and studied their clinical characteristics. Results. Thirty-seven patients met inclusion and exclusion criteria. The typical patient was young and female. Nodules averaged 3.1 cm in greatest dimension by ultrasound evaluation. Thirteen patients were found to have synchronous malignancies elsewhere in the thyroid (35%). At the time of this writing, we have not seen a clinical recurrence in any of our 37 noninvasive EFVPTC patients. Conclusions. Early clinical follow-up data suggests that the majority of noninvasive EFVPTC tumors exhibit indolent behavior, but clinical decision-making with regard to completion thyroidectomy, central lymph node dissection, and adjunctive radioiodine therapy often depends on the amount and type of synchronous thyroid cancer detected elsewhere in the thyroid gland and the central neck

Risk Profile and 3-Year Outcomes From the SYNTAX Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting Nested Registries

ObjectivesThe aim of this study was to evaluate the use of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in “real-world” patients unsuitable for the alternative treatment.BackgroundNo data are available on the risk profile and outcomes of patients that can only undergo PCI or CABG.MethodsIn the SYNTAX (Synergy between PCI with TAXUS and Cardiac Surgery) trial, a multidisciplinary Heart Team reached a consensus on whether PCI and CABG could result in clinical equipoise; if so, the patient was randomized. If not, the patient was enrolled in a CABG-ineligible PCI registry or PCI-ineligible CABG registry. A proportion (60%) of patients in the CABG registry was randomly assigned to be followed up for 5 years. No statistical comparisons were performed between randomized and registry patients. Major adverse cardiac or cerebrovascular event (MACCE) rates are presented as observational only.ResultsA total of 3,075 patients were treated in the SYNTAX trial; 198 (6.4%) and 1,077 (35.0%) patients were included in PCI and CABG registries, respectively. The main reason for inclusion in the CABG registry was too complex coronary anatomy (70.9%), and the main reason for inclusion in the PCI registry was too high-risk for surgery (70.7%). Three-year MACCE was 38.0% after PCI and 16.4% after CABG. Stratification by SYNTAX score terciles demonstrated a step-wise increase of MACCE rates in both PCI and CABG registries.ConclusionsThe SYNTAX Heart Team concluded that PCI and CABG remained the only treatment options for 6.4% and 35.0% of patients, respectively. Inoperable patients with major comorbidities that underwent PCI had high MACCE rates. In patients not suitable for PCI, surgical results were excellent. (SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries, NCT00114972