Prevention of psychopathology in children:Interventions for intergenerational transmission

Children of parents with anxiety or mood disorders have an increased risk of developing an anxiety or mood disorder themselves. A qualitative review of different components of well-studied prevention programs shows that all programs use elements of psychoeducation. Programs that primarily target children often use elements of cognitive behavioral therapy. Programs aimed at the whole family contain components focused on communication between family members and parenting skills. In general, these prevention programs are effective in preventing short- and long-term anxiety/mood disorders and reducing existing symptoms in children. Future research should pay more attention to how and for whom the prevention programs are effective. Primary health care plays an important role in identifying children at risk, underscoring the importance of training professionals in early signaling psychopathology in parents and children. Children with mild complaints could be identified earlier, possibly preventing more serious problems and intensive treatment processes.</p

Prevention of psychopathology in children:Interventions for intergenerational transmission

Children of parents with anxiety or mood disorders have an increased risk of developing an anxiety or mood disorder themselves. A qualitative review of different components of well-studied prevention programs shows that all programs use elements of psychoeducation. Programs that primarily target children often use elements of cognitive behavioral therapy. Programs aimed at the whole family contain components focused on communication between family members and parenting skills. In general, these prevention programs are effective in preventing short- and long-term anxiety/mood disorders and reducing existing symptoms in children. Future research should pay more attention to how and for whom the prevention programs are effective. Primary health care plays an important role in identifying children at risk, underscoring the importance of training professionals in early signaling psychopathology in parents and children. Children with mild complaints could be identified earlier, possibly preventing more serious problems and intensive treatment processes.</p

Prevention of psychopathology in children:Interventions for intergenerational transmission

Children of parents with anxiety or mood disorders have an increased risk of developing an anxiety or mood disorder themselves. A qualitative review of different components of well-studied prevention programs shows that all programs use elements of psychoeducation. Programs that primarily target children often use elements of cognitive behavioral therapy. Programs aimed at the whole family contain components focused on communication between family members and parenting skills. In general, these prevention programs are effective in preventing short- and long-term anxiety/mood disorders and reducing existing symptoms in children. Future research should pay more attention to how and for whom the prevention programs are effective. Primary health care plays an important role in identifying children at risk, underscoring the importance of training professionals in early signaling psychopathology in parents and children. Children with mild complaints could be identified earlier, possibly preventing more serious problems and intensive treatment processes.</p

Weighing poor immunometabolic health in relatives for severity of affective symptoms:A study of patients with depressive and anxiety disorders and their siblings

BACKGROUND: Affective (i.e. depressive and anxiety) disorders often co-occur with immunometabolic diseases and related biological pathways. Although many large population-based and meta-analytic studies have confirmed this link in community and clinical samples, studies in at-risk samples of siblings of persons with affective disorders are lacking. Furthermore, this somatic-mental co-occurrence may be partially explained by familial clustering of the conditions. First, we examined whether the association between a wide range of immunometabolic diseases and related biomarker based risk-profiles with psychological symptoms replicates in at-risk siblings of probands with affective disorders. Second, leveraging on a sibling-pair design, we disentangled and quantified the effect of probands' immunometabolic health on siblings' psychological symptoms and on the association between immunometabolic health and these symptoms in siblings.METHODS: The sample included 636 participants (M age = 49.7; 62.4% female) from 256 families, each including a proband with lifetime depressive and/or anxiety disorders and at least one of their sibling(s) (N = 380 proband-sibling pairs). Immunometabolic health included cardiometabolic and inflammatory diseases, body mass index (BMI), and composite metabolic (based on the five metabolic syndrome components) and inflammatory (based on interleukin-6 and C-reactive protein) biomarker indices. Overall affective symptoms and specific atypical, energy-related depressive symptoms were derived from self-report questionnaires. Mixed-effects analyses were used to model familial clustering. RESULTS: In siblings, inflammatory disease (γ = 0.25, p = 0.013), higher BMI (γ = 0.10, p = 0.033) and metabolic index (γ = 0.28, p &lt; 0.001) were associated with higher affective symptoms, with stronger associations for atypical, energy-related depressive symptoms (additionally associated with cardiometabolic disease; γ = 0.56, p = 0.048). Immunometabolic health in probands was not independently associated with psychological symptoms in siblings nor did it moderate the association between immunometabolic health and psychological symptoms estimated in siblings.CONCLUSIONS: Our findings demonstrate that the link between later life immunometabolic health and psychological symptoms is consistently present also in adult siblings at high risk for affective disorders. Familial clustering did not appear to have a substantial impact on this association. Instead, individual lifestyle, rather than familial factors, may have a relatively higher impact in the clustering of later life immunometabolic conditions with psychological symptoms in at-risk adult individuals. Furthermore, results highlighted the importance of focusing on specific depression profiles when investigating the overlap with immunometabolic health.</p

Prevention programmes for children of parents with a mood/anxiety disorder:Systematic review of existing programmes and meta-analysis of their efficacy

Objectives: To systematically describe the characteristics and techniques of prevention programmes for children of parents with mood/anxiety disorders. In addition, recruitment approache

The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-Injuries

Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age\ua0=\ua042.4\ua0years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p\ua0=\ua00.008, explained variance ranging from 0.10 to 0.16\ua0%) and, less consistently, in suicide attempts (lowest p\ua0=\ua00.04, explained variance ranging from 0.12 to 0.23\ua0%). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI

Familial risk for depressive and anxiety disorders:associations with genetic, clinical, and psychosocial vulnerabilities

BACKGROUND: In research and clinical practice, familial risk for depression and anxiety is often constructed as a simple Yes/No dichotomous family history (FH) indicator. However, this measure may not fully capture the liability to these conditions. This study investigated whether a continuous familial loading score (FLS), incorporating family- and disorder-specific characteristics (e.g. family size, prevalence of depression/anxiety), (i) is associated with a polygenic risk score (PRS) for major depression and with clinical/psychosocial vulnerabilities and (ii) still captures variation in clinical/psychosocial vulnerabilities after information on FH has been taken into account. METHODS: Data came from 1425 participants with lifetime depression and/or anxiety from the Netherlands Study of Depression and Anxiety. The Family Tree Inventory was used to determine FLS/FH indicators for depression and/or anxiety. RESULTS: Persons with higher FLS had higher PRS for major depression, more severe depression and anxiety symptoms, higher disease burden, younger age of onset, and more neuroticism, rumination, and childhood trauma. Among these variables, FH was not associated with PRS, severity of symptoms, and neuroticism. After regression out the effect of FH from the FLS, the resulting residualized measure of FLS was still associated with severity of symptoms of depression and anxiety, rumination, and childhood trauma. CONCLUSIONS: Familial risk for depression and anxiety deserves clinical attention due to its associated genetic vulnerability and more unfavorable disease profile, and seems to be better captured by a continuous score that incorporates family- and disorder-specific characteristics than by a dichotomous FH measure