131 research outputs found

    "La Grande Vasière" mid-shelf mud belt : Holocene sedimentary structure, natural and anthropogenic impacts

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    The Quaternary sequence of the Armorican continental shelf in the Bay of Biscay is setting down above one regional erosion surface, which has been produced by successive transgressions that occurred during the last deglaciations. The few meters of the sequence covers the Holocene period and it is composed by two clean and sandy units at the base followed by thin (few decimetres) clayed sand unit and mud (few millimetres) unit in the top. The two upper units form the improperly called "La Grande Vasière" area over 8,000 km2. The settlement of these sedimentary units occurred since 8,000 C14 years BP, previously to other coastal mud fields setting of the shelf. Historical grain size data show that the mud field has lost part of the fine content during the last 30 years. "La Grande Vasière" evolves at the rhythm of the cycles of deposition and remobilization. Fluvial supplies and tide currents are the major control factors of the deposition. Bioturbation enhances the homogenization of the surficial sediments. Waves and anthropogenic actions are the main factors for the remobilization of the fine particles. The action of both the storms and the bottom trawls are tentatively quantified

    A multidisciplinary approach to the spatial dimension in ecosystem-based fisheries management

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    This study considers how to reconcile different spatial scales to find the best common denominator to be used as an ecosystem-based management unit. For this, two fishery production zones differing ecologically, economically, legally and institutionally were investigated. The first case study is located within French territorial waters, in a MPA created in 2007- the Parc Naturel Marin d'Iroise (PNMI). The second case study, the Bay of Biscay, covers both territorial waters and the French exclusive economic zone. The paper adopts a multidisciplinary approach. Relevant questions concern how marine space is shared between exploited species and fishing fleets, especially the spatial mobility strategies they employ. An assessment of the institutional system established for the PNMI contributes to the discussion of changes in coastal space use. It is obvious that the area in need of protection, defined on the basis of essential fish habitats, does not solely concern the fisheries located within the coastal zone. Experiments conducted by scientists and professionals in the Bay of Biscay provide other key points for the discussion in terms of what institutional frameworks to promote

    Mutational analysis of the PLCE1 gene in steroid-resistant nephrotic syndrome

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    International audienceBackground: Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCε1) have been recently described in patients with early-onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS). In addition, two cases of PLCE1 mutations associated with focal segmental glomerulosclerosis (FSGS) and later NS onset have been reported. Methods: In order to better assess the spectrum of phenotypes associated with PLCE1 mutations, we performed mutational analysis in a worldwide cohort of 139 patients (95 familial cases belonging to 68 families and 44 sporadic cases) with steroid-resistant NS presenting at a median age of 23.0 months (range 0-373). Results: We identified homozygous or compound heterozygous mutations in 33% (8/24) of DMS cases. PLCE1 mutations were found in 8% (6/78) of FSGS cases without NPHS2 mutations. Nine were novel mutations. No clear genotype-phenotype correlation was observed, with either truncating or missense mutations detected in both DMS and FSGS, and leading to a similar renal evolution. Surprisingly, 3 unaffected and unrelated individuals were also found to carry the homozygous mutations identified in their respective families. Conclusion: PLCE1 is a major gene of DMS and is mutated in a non-negligible proportion of FSGS cases without NPHS2 mutations. Although we did not identify additional variants in 19 candidate genes (16 other PLC genes, BRAF, IQGAP1 and NPHS1), we speculate that other modifier genes or environmental factors may play a role in the renal phenotype variability observed in individuals bearing PLCE1 mutations. This observation needs to be considered in the genetic counselling offered to patients
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