Avaliação da Água Subterrânea nos Aquíferos Cenozóico e Guarani em São Gabriel do Oeste-MS: Subsídios à Gestão Integrada

http://dx.doi.org/10.5902/2179460X13174The Cenozoic aquifer in São Gabriel do Oeste-MS occupies approximately 48% of the total area of the municipality. It consists of sandy clay and debris-lateritic Tertiary-Quaternary deposits, overlying the Guarani, Serra Geral and Aquidauna aquifers. The urban area and the main economic activities of the municipality, agriculture and swine, are located on this aquifer. Public and private water supply use exclusively groundwater, mainly from Cenozoic Aquifer, shallow wells, and Guarani Aquifer, deep wells. Economic activities, direct recharge and characteristics of permeability and porosity of this unit indicate the vulnerability of the aquifers in that region.http://dx.doi.org/10.5902/2179460X13174O Aquífero Cenozóico em São Gabriel do Oeste-MS, ocupa aproximadamente 48% da área total do município. É formado por depósitos areno-argilosos e detrito-lateríticos de idade Terciário-Quaternário, sotopostos aos Aquíferos Guarani, Serra Geral e Aquidauana. As principais atividades econômicas do município, a agricultura e a suinocultura, bem como sua sede e agroindústrias, localizam-se sobre este Aquífero. O abastecimento público e privado utilizam exclusivamente águas dos mananciais subterrâneos, explotando o Aquífero Cenozóico e as maiores vazões no Guarani subjacente ou aflorante. As atividades econômicas, a recarga direta e as características de permo-porosidade desta unidade apontam para a vulnerabilidade dos Aquíferos Cenozóico e Guarani naquela região

Ansiedade em universitários iniciantes de cursos da área da saúde / Anxiety in university beginners of health courses

O transtorno de ansiedade é considerado uma associação de sentimentos, como o medo, a angústia e a preocupação. Esse transtorno vem sendo considerado o mal do último século, dadas as mudanças significativas ocorridas na atual sociedade moderna, tecnológica e competitiva. A entrada do estudante no ensino superior é cercada de muita expectativa, nesse contexto, o ambiente universitário gera um cenário desgastante que pode provocar transtornos ansiosos nos estudantes. Dessa forma, objetivou-se investigar os níveis de ansiedade em alunos universitários de 1º período nos cursos da área da saúde da UniFacema. Esse estudo trata-se de uma pesquisa de campo, exploratória, descritiva, de corte transversal, com abordagem quantitativa. A amostra desse estudo foi constituída por 199 acadêmicos de ambos os sexos, dos primeiros períodos de cursos na área da saúde. Utilizou-se como instrumentos de coleta de dados um questionário sociodemográfico e a Escala de Ansiedade de Zung. Como resultados constatou-se que ser do sexo feminino, ser divorciado, mudar da sua localidade para estudar, cursar Odontologia ou Educação Física configuraram-se como fator de risco para ansiedade. Conclui-se que o início da graduação é um momento novo e que muitas vezes podem deixar o sujeito ansioso, diante disso, foram observados níveis normais de ansiedade e ainda, ansiedade leve. Neste ponto, observa-se a importância de uma abordagem multidisciplinar a estes acadêmicos, com ênfase nos cuidados psicológicos, destacando o papel do psicólogo para a prevenção de quadros de ansiedade patológica

In VitroImmunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-02-21T19:11:48Z No. of bitstreams: 1 Carvalho NB In Vitro Immunomodulatory Activity....pdf: 814459 bytes, checksum: fbc26d0956ea00ebc93858d871681615 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-02-21T19:27:04Z (GMT) No. of bitstreams: 1 Carvalho NB In Vitro Immunomodulatory Activity....pdf: 814459 bytes, checksum: fbc26d0956ea00ebc93858d871681615 (MD5)Made available in DSpace on 2018-02-21T19:27:05Z (GMT). No. of bitstreams: 1 Carvalho NB In Vitro Immunomodulatory Activity....pdf: 814459 bytes, checksum: fbc26d0956ea00ebc93858d871681615 (MD5) Previous issue date: 2017Ministry of Health, National Council for Scientific and Technological Development (CNPq) from Brazil (467207/2014-3), and Coordination for the Improvement of Higher Education Personnel (CAPES).Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilPontifícia Universidade Católica do Rio Grande do Sul. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, BrasilPontifícia Universidade Católica do Rio Grande do Sul. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, BrasilPontifícia Universidade Católica do Rio Grande do Sul. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, BrasilPontifícia Universidade Católica do Rio Grande do Sul. Centro de Pesquisas em Biologia Molecular e Funcional. Porto Alegre, RS, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilCutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused byLeishmania(Viannia)braziliensis. CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising agent in the treatment of diseases associated with T cell activation. Herein, we evaluated thein vitroimmunomodulatory activity of DI4G in cells of patients presenting with CL. Peripheral blood mononuclear cells (PBMC) from CL patients were stimulated with soluble leishmania antigen (SLA), in the presence or absence of DI4G, and IFN-γ, TNF, CXCL9, and CXCL10 levels were determined by ELISA. Lymphocyte proliferation in the presence or absence of DI4G was also evaluated, using flow cytometry. DI4G was able to decrease (p< 0.05) IFN-γproduction but did not change the TNF, CXCL9, and CXCL10 levels. DI4G decreased (p< 0.05) the lymphoproliferative response mediated by CD8+T cells, but not that by CD4+T cells. DI4G is able to attenuate the exaggerated immune response in CL, exhibiting immunomodulatory activity in IFN-γproduction and in CD8+T cell proliferation

Tamoxifen and meglumine antimoniate combined therapy in cutaneous leishmaniasis patients: a randomised trial

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-08-15T14:30:21Z No. of bitstreams: 1 Machado PRLTamoxifen and meglumine antimoniate....pdf: 120712 bytes, checksum: 5db0d648aa70b8a43463d2aab5a87f37 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-08-15T16:34:59Z (GMT) No. of bitstreams: 1 Machado PRLTamoxifen and meglumine antimoniate....pdf: 120712 bytes, checksum: 5db0d648aa70b8a43463d2aab5a87f37 (MD5)Made available in DSpace on 2018-08-15T16:34:59Z (GMT). No. of bitstreams: 1 Machado PRLTamoxifen and meglumine antimoniate....pdf: 120712 bytes, checksum: 5db0d648aa70b8a43463d2aab5a87f37 (MD5) Previous issue date: 2018Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP 2015/09080-2). SRBU is the recipient of a sênior researcher scholarship from CNPqUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, BrasilUniversidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, BrasilThere is a clear need for new strategies of leishmaniasis treatment. This work was conducted to evaluate the efficacy of the co-administration of tamoxifen and meglumine antimoniate (SbV ) in a phase II pilot clinical trial in localised cutaneous leishmaniasis patients. methods A randomised controlled pilot clinical trial was conducted to evaluate the efficacy and safety of oral (40 mg/day for 20 days) or topical tamoxifen (0.1% tamoxifen citrate for 20 days) combined with meglumine antimoniate (20 mg SbV/kg/day for 20 days) vs. a standard SbV protocol (20 mg/kg/day for 20 days) for the treatment of cutaneous leishmaniasis. Primary outcome was complete epithelisation of the lesion 6 months after the end of treatment. Secondary outcomes were lesion healing 2 months after the end of treatment and frequency and severity of adverse events. results A total of 38 subjects were included in the trial, 15 were treated with standard SbV and 23 with the combination of tamoxifen and SbV. Of the patients treated with the co-administration scheme, 12 received tamoxifen orally and 11 were treated with topical tamoxifen. Tamoxifen administered by the oral or topical routes was well tolerated. Cure rates 6 months after the end of treatment per intention to treat were 40% in the group treated with the standard SbV scheme, and 36.4% and 58%, respectively, for groups treated with SbV plus topical or oral tamoxifen. conclusions In the doses and schemes used in this study, co-administration of oral tamoxifen and SbV resulted in higher cure rates in comparison with the standard scheme of treatment, although not to statistically significant levels

Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial

Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P <.01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P =.15). Secondary end points did not differ between groups after follow-up. Conclusions: The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death. © 2019 The Author