5,413 research outputs found
Early weight loss in parkinsonism predicts poor outcomes : evidence from an incident cohort study
This study was funded by Parkinsonâs UK, the Scottish Chief Scientist Office, NHS Grampian endowments, the BMA Doris Hillier award, RS Macdonald Trust, the BUPA Foundation, and the Special Parkinsonâs Research Interest Group (SPRING). The Article Processing Charge was funded by Parkinson's UK.Peer reviewedPublisher PD
Radio-frequency reflectometry on an undoped AlGaAs/GaAs single electron transistor
Radio frequency reflectometry is demonstrated in a sub-micron undoped
AlGaAs/GaAs device. Undoped single electron transistors (SETs) are attractive
candidates to study single electron phenomena due to their charge stability and
robust electronic properties after thermal cycling. However these devices
require a large top-gate which is unsuitable for the fast and sensitive radio
frequency reflectometry technique. Here we demonstrate rf reflectometry is
possible in an undoped SET.Comment: Four pages, three figures, one supplementary fil
Methanol Masers as Tracers of Circumstellar Disks
We show that in many methanol maser sources the masers are located in lines,
with a velocity gradient along them which suggests that the masers are situated
in edge-on circumstellar, or protoplanetary, disks. We present VLBI
observations of the methanol maser source G309.92+0.48, in the 12.2 GHz
transition, which confirm previous observations that the masers in this source
lie along a line. We show that such sources are not only linear in space but,
in many cases, also have a linear velocity gradient. We then model these and
other data in both the 6.7 GHz and the 12.2 GHz transition from a number of
star formation regions, and show that the observed spatial and velocity
distribution of methanol masers, and the derived Keplerian masses, are
consistent with a circumstellar disk rotating around an OB star. We consider
this and other hypotheses, and conclude that about half of these methanol
masers are probably located in edge-on circumstellar disks around young stars.
This is of particular significance for studies of circumstellar disks because
of the detailed velocity information available from the masers.Comment: 38 pages, 13 figures accepted by Ap
Sociomateriality: A Theoretical Framework for Studying Distributed Medical Education
Distributed medical education (DME) is a type of distance learning in which students participate in medical education from diverse geographic locations using Web conferencing, videoconferencing, e-learning, and similar tools. DME is becoming increasingly widespread in North America and around the world. Although relatively new to medical education, distance learning has a long history in the broader field of education and a related body of literature that speaks to the importance of engaging in rigorous and theoretically informed studies of distance learning. The existing DME literature is helpful, but it has been largely descriptive and lacks a critical "lens"-that is, a theoretical perspective from which to rigorously conceptualize and interrogate DME's social (relationships, people) and material (technologies, tools) aspects. The authors describe DME and theories about distance learning and show that such theories focus on social, pedagogical, and cognitive considerations without adequately taking into account material factors. They address this gap by proposing sociomateriality as a theoretical framework allowing researchers and educators to study DME and (1) understand and consider previously obscured actors, infrastructure, and other factors that, on the surface, seem unrelated and even unimportant; (2) see clearly how the social and material components of learning are intertwined in fluid, messy, and often uncertain ways; and (3) perhaps think differently, even in ways that disrupt traditional approaches, as they explore DME. The authors conclude that DME brings with it substantial investments of social and material resources, and therefore needs careful study, using approaches that embrace its complexity
Cost-benefit analysis for commissioning decisions in GEO600
Gravitational wave interferometers are complex instruments, requiring years
of commissioning to achieve the required sensitivities for the detection of
gravitational waves, of order 10^-21 in dimensionless detector strain, in the
tens of Hz to several kHz frequency band. Investigations carried out by the
GEO600 detector characterisation group have shown that detector
characterisation techniques are useful when planning for commissioning work. At
the time of writing, GEO600 is the only large scale laser interferometer
currently in operation running with a high duty factor, 70%, limited chiefly by
the time spent commissioning the detector. The number of observable
gravitational wave sources scales as the product of the volume of space to
which the detector is sensitive and the observation time, so the goal of
commissioning is to improve the detector sensitivity with the least possible
detector down time. We demonstrate a method for increasing the number of
sources observable by such a detector, by assessing the severity of
non-astrophysical noise contaminations to efficiently guide commissioning. This
method will be particularly useful in the early stages and during the initial
science runs of the aLIGO and adVirgo detectors, as they are brought up to
design performance.Comment: 17 pages, 17 figures, 2 table
Variability selected high-redshift quasars on SDSS Stripe 82
The SDSS-III BOSS Quasar survey will attempt to observe z>2.15 quasars at a
density of at least 15 per square degree to yield the first measurement of the
Baryon Acoustic Oscillations in the Ly-alpha forest. To help reaching this
goal, we have developed a method to identify quasars based on their variability
in the u g r i z optical bands. The method has been applied to the selection of
quasar targets in the SDSS region known as Stripe 82 (the Southern equatorial
stripe), where numerous photometric observations are available over a 10-year
baseline. This area was observed by BOSS during September and October 2010.
Only 8% of the objects selected via variability are not quasars, while 90% of
the previously identified high-redshift quasar population is recovered. The
method allows for a significant increase in the z>2.15 quasar density over
previous strategies based on optical (ugriz) colors, achieving a density of
24.0 deg^{-2} on average down to g~22 over the 220 deg^2 area of Stripe 82. We
applied this method to simulated data from the Palomar Transient Factory and
from Pan-STARRS, and showed that even with data that have sparser time sampling
than what is available in Stripe 82, including variability in future quasar
selection strategies would lead to increased target selection efficiency in the
z>2.15 redshift range. We also found that Broad Absorption Line quasars are
preferentially present in a variability than in a color selection.Comment: 14 pages, 21 figures, accepted for publication in A&
The Type I Superluminous Supernova PS16aqv: Lightcurve Complexity and Deep Limits on Radioactive Ejecta in a Fast Event
[Abridged] We present UV/optical observations of PS16aqv (SN 2016ard), a Type
I superluminous supernova (SLSN-I) classified as part of our search for low-
SLSNe. PS16aqv is a fast evolving SLSNe-I that reached a peak absolute
magnitude of . The lightcurves exhibit a significant
undulation at 30 rest-frame days after peak, with a behavior similar to
undulations seen in the slowly fading SLSN-I SN 2015bn. This similarity
strengthens the case that fast and slow SLSNe-I form a continuum with a common
origin. At days after peak, the lightcurves exhibit a transition
to a slow decline, followed by significant subsequent steepening, indicative of
a plateau phase or a second significant undulation. Deep limits at
days after peak imply a tight constraint on the nickel mass, M (lower than for previous SLSNe-I), and indicate that
some SLSNe-I do not produce significantly more nickel than normal Type Ic SNe.
Using MOSFiT, we model the lightcurve with a magnetar central engine model and
find ms, G, and
M. The implied rapid spin-down time and large
reservoir of available energy coupled with the high ejecta mass may account for
the fast evolving lightcurve and slow spectroscopic evolution. We also study
the location of PS16aqv in its host galaxy and find that it occurred at an
offset of kpc from the central star-forming region. We find the
host galaxy exhibits low metallicity and spatially varying extinction and star
formation rate, with the explosion site exhibiting lower values than the
central region. The complexity seen in the lightcurves of PS16aqv and other
events highlights the importance of obtaining well-sampled lightcurves for
exploring deviations from a uniform decline.Comment: 16 pages, 10 figures, submitted to Ap
Systematic review and meta-analysis of temozolomide in animal models of glioma:was clinical efficacy predicted?
Background:Malignant glioma is an aggressive tumour commonly associated with a dismal outcome despite optimal surgical and radio-chemotherapy. Since 2005 temozolomide has been established as first-line chemotherapy. We investigate the role of in vivo glioma models in predicting clinical efficacy.Methods:We searched three online databases to systematically identify publications testing temozolomide in animal models of glioma. Median survival and number of animals treated were extracted and quality was assessed using a 12-point scale; random effects meta-analysis was used to estimate efficacy. We analysed the impact of study design and quality and looked for evidence of publication bias.Results:We identified 60 publications using temozolomide in models of glioma, comprising 2443 animals. Temozolomide prolonged survival by a factor of 1.88 (95% CI 1.74-2.03) and reduced tumour volume by 50.4% (41.8-58.9) compared with untreated controls. Study design characteristics accounted for a significant proportion of between-study heterogeneity, and there was evidence of a significant publication bias.Conclusion:These data reflect those from clinical trials in that temozolomide improves survival and reduces tumour volume, even after accounting for publication bias. Experimental in vivo glioma studies of temozolomide differ from those of other glioma therapies in their consistent efficacy and successful translation into clinical medicine
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