Web Based Postgraduate Thesis/Dessertation System - A Prototype

With the advancement of information communication technology in Malaysia, education field should take advantage to upgrade their learning and management techniques. Students should be allowed to learn anytime, anywhere and at their own place. However administration and lecture should be able to manage their work more effective and flexible. The web-based system is effective way to learning and managing education works. This report outlines the development of a web-based postgraduate thesis/dissertation management system (WPTS), which aimed to assist thesis/dissertation administration, supervisor and students in the better integration during students doing the thesis/dissertation works. This prototype system base on case study with a group of MSC(IT), administration, lecturer and students who participate in thesis/dissertation management activities. This report also presenting the tests conducted with users, it also contributed some perspective regarding benefits that gain by administration, supervisor and students, and recommends future application of the approach

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

The Molecular Landscape of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): A Literature Review

The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding overtreatment of patients with NIFTP lesions who in the past were diagnosed with thyroid carcinoma and typically received completion thyroidectomy followed by radioactive iodine ablation. The pathologic diagnosis of NIFTP requires surgical removal of the thyroid lesion or the lobe harboring it, and thorough sampling of the complete interface between the tumor capsule and the thyroid parenchyma, to exclude foci of invasion. From a cytologic point of view, the unequivocal differential diagnosis between NIFTP and infiltrative follicular variant of papillary thyroid carcinoma in fine-needle aspiration is close to impossible based on cellular and architectural features. Therefore, use of adjunct molecular testing on fine-needle aspiration specimens may be essential for the preoperative diagnosis of low-risk tumors such as NIFTP for appropriate patient management. This review discusses and summarizes the existing known literature on molecular characteristics of NIFTP tumors, so far reported, including cases retrospectively classified or prospectively diagnosed as NIFTP. Brief reference is also made to new and promising approaches applicable to the diagnosis of this tumor

Monte Croce - Guardia. 2016

Si forniscono informazioni preliminari a riguardo della campagna di scavo 2016 dal Dipartimento di Scienze dell'Atchità - Università sapienza- Roma.Preliminary information about the archeaological excavation conducted during 2016 by Department of Antiquity - Sapienza University of Rome

A Late Onset of Wernicke-Korsakoff Encephalopathy After Biliopancreatic Diversion: a Case Report

Wernicke-Korsakoff encephalopathy (WKE) is a neurologic disease due to a severe thiamine deficiency. This vitamin, an essential cofactor for cellular metabolism, is not produced by the human organism, so its total supply comes from diet, being absorbed from the duodenum. Wernicke described its acute onset in 1881; its classic form is characterized by the triad of ataxia, abnormal mental state, and ocular abnormalities (especially nystagmus). Although it is most commonly associated with chronic alcohol misuse (90% of all cases in USA), other medical conditions resulting in inadequate thiamine intake, such as gastrointestinal disease (vomiting, diarrhea), hyperemesis gravidarum, hemodialysis, sepsis, GI cancer, Crohn’s disease, psychiatric disorders, HIV infection, and malnutrition can determinate the onset of the disease. Another well-established cause of WKE is bariatric surgery. However, in most bariatric surgery-related cases, there were no specific neurological symptoms and no definitive neuroimaging markers were established. Moreover, a recent review upon the most common bariatric procedures showed that the large majority of cases develop in a range of onset between 4 and 12 weeks post-surgery (12 days up to 18 months). No significant difference in the time of onset in the different surgical procedures was observed. Roux-en-Y gastric bypass was the most related procedure (52%), followed by sleeve gastrectomy (21%); biliopancreatic diversion was associated with a small percentage of cases of WKE (3%). Biliopancreatic diversion is a single surgical procedure combining a sleeve gastrectomy and gut bypass, connecting the reduced stomach (about the 20% of the former organ) and the second tract of duodenum with the last part of the small intestine, with the aim to reduce calorie and nutrient absorption. Precipitating factors were persistent vomiting, diarrhea, rapid weight loss, anorexia, minimal food intake or glucose-containing intravenous feeding, alcohol misuse, and noncompliance with vitamin supplements

The fifth cranial nerve in headaches

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists

Neutrophil-to-lymphocyte ratio but not monocyte-to-HDL cholesterol ratio nor platelet-to-lymphocyte ratio correlates with early stages of lower extremity arterial disease: An ultrasonographic study

Objective: The role of inflammatory markers as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-high-density lipoprotein-cholesterol ratio (MHR), and platelet-to-lymphocyte ratio (PLR) in cardiovascular diseases has been widely investigated in recent years. In the context of lower extremity arterial disease (LEAD), this association has been mainly studied in the advanced stages. The aim of our study was to investigate the role of these inflammatory markers in all stages of LEAD, including early ones, using ultrasonography as diagnostic tool, together with ankle- brachial index (ABI) determination. Patients and Methods: In this cross-sectional observational study, we enrolled 240 patients undergoing ultrasonographic evaluation of the lower limb arteries and ABI determination because of symptoms suggestive of LEAD or presence of known cardiovascular risk factors. Results: In our study population, we found that ultrasonographic categories of LEAD were associated with NLR, but not with MHR and PLR. Conclusions: These results confirm that a specific pattern of inflammation can be found in all stages of LEAD, including early ones