A W:B4C multilayer phase retarder for broadband polarization analysis of soft x-ray radiation \ud

A W:B4C multilayer phase retarder has been designed and characterized which shows a nearly constant phase retardance between 640 and 850 eV photon energies when operated near the Bragg condition. This freestanding transmission multilayer was used successfully to determine, for the first time, the full polarization vector at soft x-ray energies above 600 eV, which was not possible before due to the lack of suitable optical elements. Thus, quantitative polarimetry is now possible at the 2p edges of the magnetic substances Fe, Co, and Ni for the benefit of magnetic circular dichroism spectroscopy employing circularly polarized synchrotron radiatio

Spectral information for detection of acoustic time to arrival

The exponential increase of intensity for an approaching sound source provides salient information for a listener to make judgments of time to arrival (TTA). Specifically, a listener will experience a greater rate of increasing intensity for higher than for lower frequencies during a sound source’s approach. To examine the relative importance of this spectral information, listeners were asked to makejudgments about the arrival times of nine 1-octave-band sound sources (the bands were consecutive, nonoverlapping single octaves, ranging from 40–80 Hz to ~10–20 kHz). As is typical in TTA tasks, listeners tended to underestimate the arrival time of the approaching sound source. In naturally occurring and independently manipulated amplification curves, bands with center frequencies between 120 and 250 Hz caused the least underestimation, and bands with center frequencies between 2000 and 7500 Hz caused the most underestimation. This spectral influence appears to be related to the greater perceived urgency of higher-frequency sounds

Suitability of hybrid gravitational waveforms for unequal-mass binaries

This article studies sufficient accuracy criteria of hybrid post-Newtonian (PN) and numerical relativity (NR) waveforms for parameter estimation of strong binary black-hole sources in second- generation ground-based gravitational-wave detectors. We investigate equal-mass non-spinning binaries with a new 33-orbit NR waveform, as well as unequal-mass binaries with mass ratios 2, 3, 4 and 6. For equal masses, the 33-orbit NR waveform allows us to recover previous results and to extend the analysis toward matching at lower frequencies. For unequal masses, the errors between different PN approximants increase with mass ratio. Thus, at 3.5PN, hybrids for higher-mass-ratio systems would require NR waveforms with many more gravitational-wave (GW) cycles to guarantee no adverse impact on parameter estimation. Furthermore, we investigate the potential improvement in hybrid waveforms that can be expected from 4th order post-Newtonian waveforms, and find that knowledge of this 4th post-Newtonian order would significantly improve the accuracy of hybrid waveforms.Comment: 11 pages, 14 figure

OPPORTUNITIES FOR GAS-PHAS MOLECULAR SPECTROSCOPY ON THE VLS-PGM BEAMLINE AT THE CANADIAN LIGHT SOURCE

The VLS-PGM beamline at the Canadian Light Source cover the energy range from 12eV to 250eV with a resolving power better than 10$^{4}$ throughout this range. Associated with this beamline are two endstations designed for gas phase spectroscopy. The first is a dual toroid electrostatic particle energy analyser. Each toroid can (independently) measure the energy and angular distribution of charged particles emitted from the interaction region and can be set for either positive ions or electrons. This allows both photoelectron and ion kinetic energy spectra to be recorded. Recent results from this instrument will be presented including both high resolution photoelectron spectra and photoelectron asymmetry parameter ($beta$) spectra. Coincidence circuitry exists to allow, in favourable circumstances,the measurement of molecular frame photoelectron angular distributions (MFPADs) where the detection of an ion fragment allows orientation of the parent molecule to be deduced. The second is a Wiley-McLaren Time-of-Flight mass spectrometer equipped with multihit electronics. This allows partial ion yield (PIY) spectra to be recorded as well as multi-ion coincidence spectra (PePIPICO). Again recent results will be presented looking at double ionisation in benzene like molecules

First direct comparison of non-disrupting neutron star-black hole and binary black hole merger simulations

We present the first direct comparison of numerical simulations of neutron star-black hole and black hole-black hole mergers in full general relativity. We focus on a configuration with non spinning objects and within the most likely range of mass ratio for neutron star-black hole systems (q=6). In this region of the parameter space, the neutron star is not tidally disrupted prior to merger, and we show that the two types of mergers appear remarkably similar. The effect of the presence of a neutron star on the gravitational wave signal is not only undetectable by the next generation of gravitational wave detectors, but also too small to be measured in the numerical simulations: even the plunge, merger and ringdown signals appear in perfect agreement for both types of binaries. The characteristics of the post-merger remnants are equally similar, with the masses of the final black holes agreeing within dM< 5 10^{-4}M_BH and their spins within da< 10^{-3}M_BH. The rate of periastron advance in the mixed binary agrees with previously published binary black hole results, and we use the inspiral waveforms to place constraints on the accuracy of our numerical simulations independent of algorithmic choices made for each type of binary. Overall, our results indicate that non-disrupting neutron star-black hole mergers are exceptionally well modeled by black hole-black hole mergers, and that given the absence of mass ejection, accretion disk formation, or differences in the gravitational wave signals, only electromagnetic precursors could prove the presence of a neutron star in low-spin systems of total mass ~10Msun, at least until the advent of gravitational wave detectors with a sensitivity comparable to that of the proposed Einstein Telescope.Comment: 13 pages, 9 figure

Microfluidic device for drug delivery

A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual

Maximum Strength, Rate of Force Development, Jump Height, and Peak Power Alterations in Weightlifters across Five Months of Training

The purpose of this monitoring study was to investigate how alterations in training affect changes in force-related characteristics and weightlifting performance. Subjects: Seven competitive weightlifters participated in the study. Methods: The weightlifters performed a block style periodized plan across 20 weeks. Force plate data from the isometric mid-thigh pull and static jumps with 0 kg, 11 kg, and 20 kg were collected near the end of each training block (weeks 1, 6, 10, 13, 17, and 20). Weightlifting performance was measured at weeks 0, 7, 11, and 20. Results: Very strong correlations were noted between weightlifting performances and isometric rate of force development (RFD), isometric peak force (PF), peak power (PP), and jump height (JH). Men responded in a more predictable manner than the women. During periods of higher training volume, RFD was depressed to a greater extent than PF. JH at 20 kg responded in a manner reflecting the expected fatigue response more so than JH at 0 kg and 11 kg. Conclusions: PF appears to have been more resistant to volume alterations than RFD and JH at 20 kg. RFD and JH at 20 kg appear to be superior monitoring metrics due to their “sensitivity.

An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification

We have created a novel chip-based diagnostic tools based upon quantification of metabolites using enzymes specific for their chemical conversion. Using this device we show for the first time that a solid-state circuit can be used to measure enzyme kinetics and calculate the Michaelis-Menten constant. Substrate concentration dependency of enzyme reaction rates is central to this aim. Ion-sensitive field effect transistors (ISFET) are excellent transducers for biosensing applications that are reliant upon enzyme assays, especially since they can be fabricated using mainstream microelectronics technology to ensure low unit cost, mass-manufacture, scaling to make many sensors and straightforward miniaturisation for use in point-of-care devices. Here, we describe an integrated ISFET array comprising 216 sensors. The device was fabricated with a complementary metal oxide semiconductor (CMOS) process. Unlike traditional CMOS ISFET sensors that use the Si3N4 passivation of the foundry for ion detection, the device reported here was processed with a layer of Ta2O5 that increased the detection sensitivity to 45 mV/pH unit at the sensor readout. The drift was reduced to 0.8 mV/hour with a linear pH response between pH 2 – 12. A high-speed instrumentation system capable of acquiring nearly 500 fps was developed to stream out the data. The device was then used to measure glucose concentration through the activity of hexokinase in the range of 0.05 mM – 231 mM, encompassing glucose’s physiological range in blood. Localised and temporal enzyme kinetics of hexokinase was studied in detail. These results present a roadmap towards a viable personal metabolome machine