22 research outputs found
SAT0631 Inter-observer and intra-observer reliability of the omeract ultrasonographic (US) criteria for the diagnosis of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal (MCP), wrist, acromion-clavicular (AC) and hip joints
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Connective tissue activation. xxxvi. the origin, variety, distribution, and biologic fate of connective tissue activating peptide–iii isoforms: characteristics in patients with rheumatic, renal, and arterial disease
Objective. To determine the origin, distribution, and biologic fate of platelet-derived connective tissue activating peptide–III (CTAP-III), to define the relative amounts of the antigen forms (CTAP-III, betathromboglobulin [Β-TG], neutrophil activating peptide–2 [NAP-2]) in plasma of normal persons and those with rheumatic or end-stage renal disease, and to define the isoforms of CTAP-III in platelets, plasma, transudates, and tissue deposits. Methods. CTAP-III in plasma was measured by enzyme-linked immunosorbent assay, and growth promoting activity of CTAP-III isoforms was tested in synovial and peritoneal cell cultures by measuring increased synthesis of 14 C-glycosaminoglycan ( 14 C-GAG) and 3 H-DNA. Isolated CTAP-III was characterized by Western blotting, microsequencing, and mass spectrometry. Results. CTAP-III was the primary isoform of this antigen family in normal platelets and platelet-rich plasma; Β-TG and NAP-2 accounted for 90%), and Β-TG was the most rare (0–1%). Deposition of CTAP-III in tissues, such as synovium, spleen, and kidney, is associated with partial processing to NAP-2–like isoforms and the potential to induce neutrophil and fibroblast activation in patients with rheumatic or end-stage renal disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37798/1/1780360816_ftp.pd
Use of Noninvasive Gas Exchange to Track pulmonary Vascular Responses to exercise in Heart Failure
We determined whether a non-invasive gas exchange based estimate of pulmonary vascular (PV) capacitance [PV CAP = stroke volume (SV) x pulmonary arterial pressure (Ppa)] (GX CAP ) tracked the PV response to exercise in heart-failure (HF) patients. Pulmonary wedge pressure (Ppw), Ppa, PV resistance (PVR), and gas exchange were measured simultaneously during cycle exercise in 42 HF patients undergoing right-heart catheterization. During exercise, P ET CO 2 and V E /VCO 2 were related to each other ( r = -0.93, P < 0.01) and similarly related to mean Ppa (mPpa) ( r = -0.39 and 0.36; P < 0.05); P ET CO 2 was subsequently used as a metric of mPpa. Oxygen pulse (O 2 pulse) tracked the SV response to exercise (r = 0.91, P < 0.01). Thus, GX CAP was calculated as O 2 pulse x P ET CO 2 . During exercise, invasively determined PV CAP and non-invasive GX CAP were related (r = 0.86, P < 0.01), and GX CAP correlated with mPpa and PVR (r = -0.46 and -0.54; P < 0.01). In conclusion, noninvasive gas exchange measures may represent a simple way to track the PV response to exercise in HF
Should algorithms for minute ventilation based rate adaptive pacemakers compensate for metabolic acidosis during exercise?
Ventilation and Heart Rate Response During Exercise in Normals: Relevance for Rate Variable Pacing
Estimativa da prevalência de neoplasia cerebral na faixa etária pediátrica pelo método de captura-recaptura Estimative prevalence of cerebral neoplasm of childhood from the capture-recapture method
O estudo teve como objetivo estimar a prevalência e a letalidade das neoplasias cerebrais primárias em crianças entre 1-15 anos, Bahia, 1995. O desenho foi de corte transversal, incluindo todos os casos de neoplasia cerebral diagnosticados por múltiplas fontes. A partir dos casos identificados foi utilizado o método de captura-recaptura para estimar o provável número real de casos e medir as prevalências, com intervalos de confiança (IC) a 95%. Por este método estimou-se a existência de 87 casos (IC = 64 ;111) de neoplasias cerebrais no Estado, sendo 72 (IC =54 ; 91) na capital. A prevalência resultante foi 1,85/100 000 crianças entre 1 e 15 anos (IC =1,36; 2,36/100 000) para o Estado e 10,1/100 000 (IC = 7,58 ;12,77/100 000) para a capital. A letalidade foi 5,4% (IC = 4% ; 8%) para a capital e 8,9% (IC =7% ; 13%) para o estado. O método de captura-recaptura mostrou elevada precisão na estimativa do total de casos. PossÃveis causas para o não diagnóstico e/ou tratamento das neoplasias cerebrais são comentadas.<br>The aim of the study was to estimate the prevalence and fatality rate of primary cerebral neoplasms among children between 1 and 15 years old, State of Bahia, Brazil,1995. It was a cross-sectional study which includes all cases of brain tumors diagnosed by several sources. From these cases the capture-recapture method was used to estimate the probable number of cases and measure the prevalence and confidence intervals at 95%. By this method it was estimated the existence of 87 cases (CI = 64 ; 111) of brain tumores in the State, being 72 (CI = 54 ; 91) in the capital. The estimated prevalence was 1.85/100 000 for children between 1 to 15 years old (CI = 1.36 ; 2.36/100 000) for the State, and 10.1/100,000 (CI = 7.58 ; 12.77/100,000) for the capital. The fatality rate was 5.4 percent (CI = 4% ; 8%), and 8.9% (CI = 7% ; 13%) for the capital and the State respectively. The capture-recapture method showed high precision to estimate the total number of cases. Possible causes of no diagnostic nor treatment of cerebral neoplasms are discussed