667 research outputs found
New measurements of total ionizing dose in the lunar environment
[1] We report new measurements of solar minimum ionizing radiation dose at the Moon onboard the Lunar Reconnaissance Orbiter (LRO) from June 2009 through May 2010. The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) instrument on LRO houses a compact and highly precise microdosimeter whose design allows measurements of dose rates below 1 micro-Rad per second in silicon achieved with minimal resources (20 g, ā¼250 milliwatts, and ā¼3 bits/second). We envision the use of such a small yet accurate dosimeter in many future spaceflight applications where volume, mass, and power are highly constrained. As this was the first operation of the microdosimeter in a space environment, the goal of this study is to verify its response by using simultaneous measurements of the galactic cosmic ray ionizing environment at LRO, at L1, and with other concurrent dosimeter measurements and model predictions. The microdosimeter measured the same short timescale modulations in the galactic cosmic rays as the other independent measurements, thus verifying its response to a known source of minimum-ionizing particles. The total dose for the LRO mission over the first 333 days was only 12.2 Rads behind ā¼130 mils of aluminum because of the delayed rise of solar activity in solar cycle 24 and the corresponding lack of intense solar energetic particle events. The dose rate in a 50 km lunar orbit was about 30 percent lower than the interplanetary rate, as one would expect from lunar obstruction of the visible sky
Self-assembly of magnetic biofunctional nanoparticles
Spherical, ferromagnetic FePt nanoparticles with a particle size of 3 nm were prepared by the simultaneous polyol reduction of Fe(acac)3Fe(acac)3 and Pt(acac)2Pt(acac)2 in phenyl ether in the presence of oleic acid and oleylamine. The oleic acid ligands can be replaced with 11-mercaptoundecanoic acid, giving particles that can be dispersed in water. Both x-ray diffraction and transmission electron microscopy indicated that FePt particles were not affected by ligands replacement. Dispersions of the FePt particles with 11-mercaptoundecanoic acid ligands and ammonium counter ions gave self-assembled films consisting of highly ordered hexagonal arrays of particles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87511/2/10Q901_1.pd
Determining fluid migration and isolation times in multiphase crustal domains using noble gases
Geochemical characteristics in subsurface fluid systems provide a wealth of information about fluid sources, migration, and storage conditions. Determining the extent of fluid interaction (aquifer-hydrocarbon connectivity) is important for oil and gas production and waste storage applications, but is not tractable using traditional seismic methods. Furthermore, the residence time of fluids is critical in such systems and can vary from tens of thousands to billions of years. Our understanding of the transport length scales in multiphase systems, while equally important, is more limited. Noble gas data from the Rotliegend natural gas field, northern Germany, are used here to determine the length scale and isolation age of the combined water-gas system. We show that geologically bound volume estimates (i.e., gas to water volume ratios) match closed-system noble gas model predictions, suggesting that the Rotliegend system has remained isolated as a closed system since hydrocarbon formation. Radiogenic helium data show that fluid isolation occurred 63ā129 m.y. after rock and/or groundwater deposition (ca. 300 Ma), which is consistent with known hydrocarbon generation from 250 to 140 Ma, thus corroborating long-term geologic isolation. It is critical that we have the ability to distinguish between fluid systems that, despite phase separation, have remained closed to fluid loss from those that have lost oil or gas phases. These findings are the first to demonstrate that such systems remain isolated and fully gas retentive on time scales >100 m.y. over >10 km length scales, and have broad implications for saline aquifer CO2 disposal site viability and hydrocarbon resource prediction, which both require an understanding of the length and time scales of crustal fluid transport pathways
Light noble gas composition of different solar wind regimes: results from genesis
The Genesis mission provided samples of solar wind
(SW) from different regions on the Sun. These SW regime samples are
important in understanding fractionation processes upon formation and
acceleration of the SW to ultimately deduce solar composition from SW
values. We present He and Ne isotopic and elemental compositions of the
bulk SW (SW of entire collection period) and the 3 major SW regimes: slow
(from the ecliptic plane, emanating from above streamers), fast (emanating
from coronal holes), and coronal mass ejections (CME). At the conference
we will also present Ar data
Mass-fractionation induced by the Genesis solar wind concentrator: Analysis of neon isotopes by UV laser ablation
The solar wind (SW) concentrator, a key instrument onboard the
Genesis mission, was designed to provide larger fluences of implanted SW
for precise isotope analyses of oxygen and nitrogen [1]. SW ions in the mass
range 4ā28 amu were accelerated and focused on a āconcentrator targetā by
an electrostatic mirror. This concentration process caused some instrumental
mass fractionation of the implanted SW ions as function of the radial position
on the target. Correction of this fractionation will be based on a combination
of the measured radial fractionation of Ne isotopes with results of simulations
of the implantation process using the actual performance of the concentrator
and the SW conditions during exposure. Here we present He and Ne
abundance and Ne isotopic composition data along one arm of the gold cross
that framed the 4 concentrator subtargets
School librarians as literacy educators within a complex role
Librarians in schools are expected to play an important role as literacy educators, and have a positive impact on young peopleās literacy learning. However in the context of their diverse workload, relatively little is known about how this aspect of their role sits within its competing demands, and the exact scope of the literacy educator requirements. Using a hybrid approach to content analysis, this article analyses 40 recent job description documents to identify the nature and prevalence of different aspects of the role, and to explore the literacy educator aspect of this profession. Findings suggest that while the literacy educator aspect is one of the most common role requirements, it sits within a complex workload, and the literacy educator aspect is itself multi-faceted and demanding
Syntaxin 1 Ser14 phosphorylation is required for nonvesicular dopamine release
Amphetamine (AMPH) is a psychostimulant that is commonly abused. The stimulant properties of AMPH are associated with its ability to increase dopamine (DA) neurotransmission. This increase is promoted by nonvesicular DA release mediated by reversal of DA transporter (DAT) function. Syntaxin 1 (Stx1) is a SNARE protein that is phosphorylated at Ser(14) by casein kinase II. We show that Stx1 phosphorylation is critical for AMPH-induced nonvesicular DA release and, in Drosophila melanogaster, regulates the expression of AMPH-induced preference and sexual motivation. Our molecular dynamics simulations of the DAT/Stx1 complex demonstrate that phosphorylation of these proteins is pivotal for DAT to dwell in a DA releasing state. This state is characterized by the breakdown of two key salt bridges within the DAT intracellular gate, causing the opening and hydration of the DAT intracellular vestibule, allowing DA to bind from the cytosol, a mechanism that we hypothesize underlies nonvesicular DA release
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Digital Epidemiology
Mobile, social, real-time: the ongoing revolution in the way people communicate has given rise to a new kind of epidemiology. Digital data sources, when harnessed appropriately, can provide local and timely information about disease and health dynamics in populations around the world. The rapid, unprecedented increase in the availability of relevant data from various digital sources creates considerable technical and computational challenges
Lineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales.
Betalain pigments are unique to the Caryophyllales and structurally and biosynthetically distinct from anthocyanins. Two key enzymes within the betalain synthesis pathway have been identified: 4,5-dioxygenase (DODA) that catalyzes the formation of betalamic acid and CYP76AD1, a cytochrome P450 gene that catalyzes the formation of cyclo-DOPA. We performed phylogenetic analyses to reveal the evolutionary history of the DODA and CYP76AD1 lineages and in the context of an ancestral reconstruction of pigment states we explored the evolution of these genes in relation to the complex evolution of pigments in Caryophylalles. Duplications within the CYP76AD1 and DODA lineages arose just before the origin of betalain pigmentation in the core Caryophyllales. The duplications gave rise to DODA-Ī± and CYP76AD1-Ī± isoforms that appear specific to betalain synthesis. Both betalain-specific isoforms were then lost or downregulated in the anthocyanic Molluginaceae and Caryophyllaceae. Our findings suggest a single origin of the betalain synthesis pathway, with neofunctionalization following gene duplications in the CYP76AD1 and DODA lineages. Loss of DODA-Ī± and CYP76AD1-Ī± in anthocyanic taxa suggests that betalain pigmentation has been lost twice in Caryophyllales, and exclusion of betalain pigments from anthocyanic taxa is mediated through gene loss or downregulation. [Correction added after online publication 13 May 2015: in the last two paragraphs of the Summary the gene name CYP761A was changed to CYP76AD1.].S.C. was supported by a grant to IRRI from the Bill and Melinda Gates Foundation and UKAID. This work was supported by a National Science Foundation award (grant numbers DEB 1354048 and DEB 1352907) to S.F.B., M.J.M. and S.A.S., and a NERC Independent Research Fellowship to S.F.B. The 1000 Plants (1KP) initiative, led by G.K.S.W., is funded by the Alberta Ministry of Enterprise and Advanced Education, Alberta Innovates Technology Futures (AITF), Innovates Centre of Research Excellence (iCORE), Musea Ventures and BGI-Shenzhen.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/nph.1344
Solar neon released from Genesis aluminum collector duriung stepped uv-laser extraction and step-wise pyrolysis
Earlier this year we reported results of UV-laser stepped raster extractions of Ne and He from Genesis' Al-collector [l]. Since then, using pyrolysis of a 0.005 cm^2 fragment of this material left from the earlier study, we have estimated the efficiency of the UV-laser extraction to be at least 95%. We also analyzed Ne released from the Al-collector by means of stepped pyrolysis. Here we compare these new data with stepped UV-laser extraction and the CSSE results [2]. Figure 1 shows the ^(20)Ne/^(22)Ne ratio extracted from Genesis collectors using these three techniques
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