3 research outputs found
Sedentary behaviour and brain health in middle-aged and older adults: A systematic review
Sedentary behaviour may increase the risk of dementia. Studying physiological effects of sedentary behaviour on cerebral health may provide new insights into the nature of this association. Accordingly, we reviewed if and how acute and habitual sedentary behaviour relate to brain health factors in middle-aged and older adults (≥45 years). Four databases were searched. Twenty-nine studies were included, with mainly cross-sectional designs. Nine studies examined neurotrophic factors and six studied functional brain measures, with the majority of these studies finding no associations with sedentary behaviour. The results from studies on sedentary behaviour and cerebrovascular measures were inconclusive. There was a tentative association between habitual sedentary behaviour and structural white matter health. An explanatory pathway for this effect might relate to the immediate vascular effects of sitting, such as elevation of blood pressure. Nevertheless, due to the foremost cross-sectional nature of the available evidence, reverse causality could also be a possible explanation. More prospective studies are needed to understand the potential of sedentary behaviour as a target for brain health
PulseNet news ; v. 2, issue 2, spring 2003
The National Molecular Subtyping Network ofr Foodborne Disease Surveillance.State & local public health laboratories in the United States and PulseNet Canada.Welcome to Texas -- Expanding the Net to Vector Borne Diseases -- Prioritization of PFGE Subtyping -- Excess Mortality Paper -- Asia Pacific Update -- Lab Profile: Houston -- News from PulseNet National Database -- Training -- In the News/Pubs and Abstracts -- Farewells/Welcomes -- Newsletter Surve
The Association of Sedentary Behaviour and Cognitive Function in People Without Dementia: A Coordinated Analysis Across Five Cohort Studies from COSMIC
BackgroundBesides physical activity as a target for dementia prevention,
sedentary behaviour is hypothesized to be a potential target in its own
right. The rising number of persons with dementia and lack of any
effective treatment highlight the urgency to better understand these
modifiable risk factors. Therefore, we aimed to investigate whether
higher levels of sedentary behaviour are associated with reduced global
cognitive functioning and slower cognitive decline in older persons
without dementia.MethodsWe used five population cohorts from Greece,
Australia, USA, Japan, and Singapore (HELIAD, PATH, SALSA, SGS, and
SLAS2) from the Cohort Studies of Memory in an International Consortium.
In a coordinated analysis, we assessed the relationship between
sedentary behaviour and global cognitive function with the use of linear
mixed growth model analysis (mean follow-up range of 2.0-8.1
years).ResultsBaseline datasets combined 10,450 older adults without
dementia with a mean age range between cohorts of 66.7-75.1 years. After
adjusting for multiple covariates, no cross-sectional association
between sedentary behaviour and cognition was found in four studies. One
association was detected where more sedentary behaviour was
cross-sectionally linked to higher cognition levels (SLAS2, B=0.118
(0.075; 0.160), P<0.001). Longitudinally, there were no associations
between baseline sedentary behaviour and cognitive decline
(P>0.05).ConclusionsOverall, these results do not suggest an association
between total sedentary time and lower global cognition in older persons
without dementia at baseline or over time. We hypothesize that specific
types of sedentary behaviour may differentially influence cognition
which should be investigated further. For now, it is, however, too early
to establish undifferentiated sedentary time as a potential effective
target for minimizing cognitive decline in older adults without
dementia