4,377 research outputs found

    Isolation and characterization of enterotoxin-deficient mutants of Escherichia coli.

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    Atomic dynamics in evaporative cooling of trapped alkali atoms in strong magnetic fields

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    We investigate how the nonlinearity of the Zeeman shift for strong magnetic fields affects the dynamics of rf field induced evaporative cooling in magnetic traps. We demonstrate for the 87-Rb and 23-Na F=2 trapping states with wave packet simulations how the cooling stops when the rf field frequency goes below a certain limit (for the 85-Rb F=2 trapping state the problem does not appear). We examine the applicability of semiclassical models for the strong field case as an extension of our previous work [Phys. Rev. A 58, 3983 (1998)]. Our results verify many of the aspects observed in a recent 87^{87}Rb experiment [Phys. Rev. A 60, R1759 (1999)].Comment: 9 pages, RevTex, eps figures embedde

    Between-centre differences and treatment effects in randomized controlled trials: A case study in traumatic brain injury

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    BACKGROUND: In Traumatic Brain Injury (TBI), large between-centre differences in outcome exist and many clinicians believe that such differences influence estimation of the treatment effect in randomized controlled trial (RCTs). The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI. METHODS: We used data from the MRC CRASH trial on the efficacy of corticosteroid infusion in patients with TBI. We analyzed the effect of the treatment on 14 day mortality with fixed effect logistic regression. Next we used random effects logistic regression with a random intercept to estimate the treatment effect taking into account between-centre differences in outcome. Between-centre differences in outcome were expressed with a 95% range of odds ratios (OR) for centres compared to the average, based on the variance of the random effects (tau2). A random effects logistic regression model with random slopes was used to allow the treatment effect to vary by centre. The variation in treatment effect between the centres was expressed in a 95% range of the estimated treatment ORs. RESULTS: In 9978 patients from 237 centres, 14-day mortality was 19.5%. Mortality was higher in the treatment group (OR = 1.22, p = 0.00010). Using a random effects model showed large between-centre differences in outcome (95% range of centre effects: 0.27- 3.71), but did not substantially change the estimated treatment effect (OR = 1.24, p = 0.00003). There was limited, although statistically significant, between-centre variation in the treatment effect (OR = 1.22, 95% treatment OR range: 1.17-1.26). CONCLUSION: Large between-centre differences in outcome do not necessarily affect the estimated treatment effect in RCTs, in contrast to current beliefs in the clinical area of TBI

    Post-AGB stars with hot circumstellar dust: binarity of the low-amplitude pulsators

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    While the first binary post-AGB stars were serendipitously discovered, the distinct characteristics of their Spectral Energy Distribution (SED) allowed us to launch a more systematic search for binaries. We selected post-AGB objects which show a broad dust excess often starting already at H or K, pointing to the presence of a gravitationally bound dusty disc in the system. We started a very extensive multi-wavelength study of those systems and here we report on our radial velocity and photometric monitoring results for six stars of early F type, which are pulsators of small amplitude. To determine the radial velocity of low signal-to-noise time-series, we constructed dedicated auto-correlation masks. The radial velocity variations were subjected to detailed analysis to differentiate between pulsational variability and variability due to orbital motion. Finally orbital minimalisation was performed to constrain the orbital elements. All of the six objects are binaries, with orbital periods ranging from 120 to 1800 days. Five systems have non-circular orbits. The mass functions range from 0.004 to 0.57 solar mass and the companions are likely unevolved objects of (very) low initial mass. We argue that these binaries must have been subject to severe binary interaction when the primary was a cool supergiant. Although the origin of the circumstellar disc is not well understood, the disc is generally believed to be formed during this strong interaction phase. The eccentric orbits of these highly evolved objects remain poorly understood. With the measured orbits and mass functions we conclude that the circumbinary discs seem to have a major impact on the evolution of a significant fraction of binary systems.Comment: 13 pages, 15 figures, accepted for Astronomy and Astrophysic

    Gluons at finite temperature in Landau gauge Yang--Mills theory

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    The infrared behavior of Yang-Mills theory at finite temperature provides access to the role of confinement. In this review recent results on this topic from lattice calculations and especially Dyson-Schwinger studies are discussed. These indicate persistence of a residual confinement even in the high-temperature phase. The confinement mechanism is very similar to the one in the vacuum for the chromomagnetic sector. In the chromoelectric sector screening occurs at the soft scale g^2T, although not leading to a perturbative behavior.Comment: 15 pages, 4 figures, invited brief review for MPL

    String Indexing for Patterns with Wildcards

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    We consider the problem of indexing a string tt of length nn to report the occurrences of a query pattern pp containing mm characters and jj wildcards. Let occocc be the number of occurrences of pp in tt, and σ\sigma the size of the alphabet. We obtain the following results. - A linear space index with query time O(m+σjloglogn+occ)O(m+\sigma^j \log \log n + occ). This significantly improves the previously best known linear space index by Lam et al. [ISAAC 2007], which requires query time Θ(jn)\Theta(jn) in the worst case. - An index with query time O(m+j+occ)O(m+j+occ) using space O(σk2nlogklogn)O(\sigma^{k^2} n \log^k \log n), where kk is the maximum number of wildcards allowed in the pattern. This is the first non-trivial bound with this query time. - A time-space trade-off, generalizing the index by Cole et al. [STOC 2004]. We also show that these indexes can be generalized to allow variable length gaps in the pattern. Our results are obtained using a novel combination of well-known and new techniques, which could be of independent interest

    Measurement of Strange Quark Contributions to the Nucleon's Form Factors at Q^2=0.230 (GeV/c)^2

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    We report on a measurement of the parity-violating asymmetry in the scattering of longitudinally polarized electrons on unpolarized protons at a Q2Q^2 of 0.230 (GeV/c)^2 and a scattering angle of \theta_e = 30^o - 40^o. Using a large acceptance fast PbF_2 calorimeter with a solid angle of \Delta\Omega = 0.62 sr the A4 experiment is the first parity violation experiment to count individual scattering events. The measured asymmetry is A_{phys} =(-5.44 +- 0.54_{stat} +- 0.27_{\rm sys}) 10^{-6}. The Standard Model expectation assuming no strangeness contributions to the vector form factors is A0=(6.30+0.43)106A_0=(-6.30 +- 0.43) 10^{-6}. The difference is a direct measurement of the strangeness contribution to the vector form factors of the proton. The extracted value is G^s_E + 0.225 G^s_M = 0.039 +- 0.034 or F^s_1 + 0.130 F^s_2 = 0.032 +- 0.028.Comment: 5 pages, 3 figures, submitted to Phys. Rev. Letters on Dec 11, 200

    The HypHI project: Hypernuclear spectroscopy with stable heavy ion beams and rare isotope beams at GSI and FAIR

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    The HypHI collaboration aims to perform a precise hypernuclear spectroscopy with stable heavy ion beams and rare isotope beams at GSI and fAIR in order to study hypernuclei at extreme isospin, especially neutron rich hypernuclei to look insight hyperon-nucleon interactions in the neutron rich medium, and hypernuclear magnetic moments to investigate baryon properties in the nuclei. We are currently preparing for the first experiment with 6^6Li and 12^{12}C beams at 2 AGeV to demonstrate the feasibility of a precise hypernuclear spectroscopy by identifying Λ3^{3}_{\Lambda}H, Λ4^{4}_{\Lambda}H and Λ5^{5}_{\Lambda}He. The first physics experiment on these hypernuclei is planned for 2009. In the present document, an overview of the HypHI project and the details of this first experiment will be discussed.Comment: 5 pages, 2 figures, French-Japanese symposium 2008, Paris (France

    International Federation of Clinical Chemistry (IFCC): Scientific Division, Committee on pH, Blood Gases and Electrolytes: Guidelines for Transcutaneouspo2andpco2 Measurement

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    This document provides guidelines for the terminology, methodology, and for the interpretation of data obtained from the use of skin (transcutaneous) po2 and pco2 electrodes. The transcutaneous technique has found special application in newborn infants. The causes of analytical bias with respect to arterial blood gas values, and imprecision obtained with transcutaneous pco2 electrodes, are reviewed. Electrode temperatures above 44°C should not be used routinely, and, at a measuring temperature of 44°C, the measuring site should be changed at least every 4 h to avoid skin burns

    The Muonium Atom as a Probe of Physics beyond the Standard Model

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    The observed interactions between particles are not fully explained in the successful theoretical description of the standard model to date. Due to the close confinement of the bound state muonium (M=μ+eM = \mu^+ e^-) can be used as an ideal probe of quantum electrodynamics and weak interaction and also for a search for additional interactions between leptons. Of special interest is the lepton number violating process of sponteanous conversion of muonium to antimuonium.Comment: 15 pages,6 figure
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