FeederAnt - An autonomous mobile unit feeding outdoor pigs

Small robots and the concept of decentralized animal husbandry make it possible to renew the principles of organic agriculture. The farm animals will be able to use the same type of housing and are placed integrated with the fields. This is expected to achieve a better utilization of nutrients and a better survival rate for useful insects and micro organisms. The small fields are flexible and could fit to the variation in soil structure topography. This type of precision agriculture has the possibility of increasing biodiversity. The paper presents the concept of an autonomic feeding system for outdoor piglets. Initial results are presented using a remote controlled feeding unit (a prototype of the FeederAnt) to feed several pens with piglets. The FeederAnt drives into the grass paddocks twice a day and position itself in a new location for each feeding. This will help to distribute the manure from the animals evenly over the grass paddock to prevent point leaching of nutrients. The FeederAnt replaces many stationary feeding tables and reduce the amount of daily manual feeding routines. Further, it is expected that the problem with vermins will be solved since no feed residues will be left within the pens.

HortiBot: A System Design of a Robotic Tool Carrier for High-tech Plant Nursing

Danish organic outdoor gardeners today use 50-300 hours per hectare for manual weeding. Through automatic controlling of an existing commercial machine this often heavy and costconsuming weeding will be eliminated. At the same time, a fully-automatic registration of field activities will contribute to the efficient implementation of EU directive 178/2002 concerning traceability in the primary production and thereby enhance the food-safety in the production chain. A radio controlled slope mower is equipped with a new robotic accessory kit. This transforms it into a tool carrier (HortiBot) for high-tech plant nursing for e.g. organic grown vegetables. The HortiBot is capable of passing over several parcels with visible rows autonomously based on a new commercial row detection system from Eco-Dan a/s, Denmark. This paper presents the solutions chosen for the HortiBot with regard to hardware, mechanicalelectrical interfaces and software. Further, the principles from a Quality Function Deployment (QFD) analysis was used to carry out the solicitation, evaluation and selection of most qualified design parameters and specifications attained to a horticultural robotic tool carrier. The QFD analysis provided a specific measure to evaluate each selected parameter in terms of satisfying user requirements and operational performance aspects. Based on a combination of importance rating and competitive priority ratings important user requirements include easy adaptation to field conditions in terms of row distance and parcel size, profitability, minimum crop damage during operation, and reliability. Lesser importance was attributed to affection value, attractive look, the possibility of out of season usage, and the use of renewable energy

Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet

AIM: To investigate patient-reported outcomes from, and adherence to, a low FODMAP diet among patients suffering from irritable bowel syndrome and inflammatory bowel disease. METHODS: Consecutive patients with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) and co-existing IBS fulfilling the ROME. criteria, who previously attended an outpatient clinic for low FODMAP diet (LFD) dietary management and assessment by a gastroenterologist, were invited to participate in a retrospective questionnaire analysis. The questionnaires were sent and returned by regular mail and gathered information on recall of dietary treatment, efficacy, symptoms, adherence, satisfaction, change in disease course and stool type, and quality of life. Before study enrolment all patients had to sign an informed written consent. RESULTS: One hundred and eighty patients were included, 131 (73%) IBS and 49 (27%) IBD patients. Median age was 43 years (range: 18-85) and 147 (82%) were females. Median follow-up time was 16 mo (range: 2-80). Eighty-six percent reported either partial (54%) or full (32%) efficacy with greatest improvement of bloating (82%) and abdominal pain (71%). The proportion of patients with full efficacy tended to be greater in the IBD group than in the IBS group (42% vs 29%, p = 0.08). There was a significant reduction in patients with a chronic continuous disease course in both the IBS group (25%, p < 0.001) and IBD group (23%, p = 0.002) along with a significant increase in patients with a mild indolent disease course of 37% (p < 0.001) and 23% (p = 0.002), respectively. The proportion of patients having normal stools increased with 41% in the IBS group (p < 0.001) and 66% in the IBD group (p < 0.001). One-third of patients adhered to the diet and high adherence was associated with longer duration of dietary course (p < 0.001). Satisfaction with dietary management was seen in 83 (70%) IBS patients and 24 (55%) IBD patients. Eighty-four percent of patients lived on a modified LFD, where some foods rich in FODMAPs were reintroduced, and 16% followed the LFD by the book without deviations. Wheat, dairy products, and onions were the foods most often not reintroduced by patients. CONCLUSION: These data suggest that a diet low in FODMAPs is an efficacious treatment solution in the management of functional bowel symptoms for IBS and IBD patients

Uridine Metabolism in HIV-1-Infected Patients: Effect of Infection, of Antiretroviral Therapy and of HIV-1/ART-Associated Lipodystrophy Syndrome

Background Uridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood. Methods Plasma uridine concentrations were measured in 35 controls and 221 HIV-1-infected patients and fat uridine in 15 controls and 19 patients. The diagnosis of HALS was performed following the criteria of the Lipodystrophy Severity Grading Scale. Uridine was measured by a binary gradient-elution HPLC method. Analysis of genes encoding uridine metabolizing enzymes in fat was performed with TaqMan RT-PCR. Results Median plasma uridine concentrations for HIV-1-infected patients were 3.80 µmol/l (interquartile range: 1.60), and for controls 4.60 µmol/l (IQR: 1.8) (P = 0.0009). In fat, they were of 6.0 (3.67), and 2.8 (4.65) nmol/mg of protein, respectively (P = 0.0118). Patients with a mixed HALS form had a median plasma uridine level of 4.0 (IC95%: 3.40-4.80) whereas in those with isolated lipoatrophy it was 3.25 (2.55-4.15) µmol/l/l (P = 0.0066). The expression of uridine cytidine kinase and uridine phosphorylase genes was significantly decreased in all groups of patients with respect to controls. A higher expression of the mRNAs for concentrative nucleoside transporters was found in HIV-1-infected patients with respect to healthy controls. Conclusions HIV-1 infection is associated with a decrease in plasma uridine and a shift of uridine to the adipose tissue compartment. Antiretroviral therapy was not associated with plasma uridine concentrations, but pure lipoatrophic HALS was associated with significantly lower plasma uridine concentrations

A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions

OBJECTIVE: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions.STUDY DESIGN AND SETTING: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups.RESULTS: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age, sex, patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention, timing, control intervention, cointerventions); and outcome (definition of outcome, timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters.CONCLUSION: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.</p

HortiBot: A System Design of a Robotic Tool Carrier for High-tech Plant Nursing

Rosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 9 (2007): HortiBot: A System Design of a Robotic Tool Carrier for High-tech Plant Nursing. Manuscript ATOE 07 006. Vol. IX. July, 2007

Educational training requirements for general practice/family medicine specialty training: recommendations for trainees, trainers and training institutions.

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Ivabradine for coronary artery disease and/or heart failure—a protocol for a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Abstract Background Coronary artery disease and heart failure are both highly prevalent diseases with a global prevalence of 93 million and 40 million. These patients are at increased risk of morbidity and mortality. The management of these patients involves medical therapy, and both diseases can be treated using the heart rate-lowering drug ivabradine. However, the evidence regarding the use of ivabradine in the treatment of coronary artery disease and/or heart failure is unclear. Our objective is to assess the beneficial and harmful effects of ivabradine in the treatment of coronary artery disease and/or heart failure. Methods This protocol for a systematic review was undertaken using the recommendations of The Cochrane Collaboration, the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P), and the eight-step assessment procedure suggested by Jakobsen and colleagues. We plan to include all relevant randomised clinical trials assessing the use of ivabradine in the treatment of coronary artery disease and/or heart failure. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Latin American and Caribbean Health Sciences Literature (LILACS), Science Citation Index Expanded on Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science Journal Database (VIP), and BIOSIS in order to identify relevant trials. We will begin the searches in February 2019. All included trials will be assessed and classified at low risk of bias or at high risk of bias. Our primary conclusions will be based on the results from the primary outcomes at low risk of bias. Extracted data will be analysed using Review Manager 5.3 and Trial Sequential Analysis 0.9.5.10. We will create a ‘Summary of Findings’ table in which we will present our primary and secondary outcomes, and we will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Discussion The systematic review will have the potential to aid clinicians in decision-making regarding ivabradine and to benefit patients with coronary artery disease and/or heart failure. Systematic review registration PROSPERO CRD4201811208

Assessing familiy medicine trainees - what can we learn from European neighbours?

Contains fulltext : 152872.pdf (publisher's version ) (Open Access

Conceptual and user-centric design guidelines for a plant nursing robot

Current service robots have relatively primitive behaviours and limited interaction with the environment. Technological foresights have indicated that the next generation of service robots will demonstrate a high degree of autonomy and reliability, have minimal impact on the environment, and will interact in a flexible way with the user. It is necessary therefore, to determine the functional requirements for a future energy-efficient robotic bioproduction system from the perspective of various stakeholders, together with the development of a high-level framework for designing and prototyping the common functionalities of mobile robots. This study presents technical guidelines for the design of a plant nursing robot. The methodology uses Quality Function Deployment (QFD) functionalities involving the identification of relationships between identified user requirements and the derived design parameters. Extracted important user requirements included: 1) adjustable to row distance and parcel size, 2) profitable, 3) minimize damage to crops, and 4) reliable. Lower ratings were attributed to requirements such as: 1) affection value, prestige, 2) look attractive, 3) out of season operations, and 4) use of renewable energy. Subsequent important derived design parameters included: 1) PreparedForModularTools, 2) ControlableByExternalModules, 3) SemiAutonomous, and 4) Local- and GlobalPositioningSystem. The least important design parameters included: 1) OpenStandardSoftware, 2) Well-builtAppearance, 3) Wheels- With Infinite Steering Rotation, and 4) Internal Safety System. The study demonstrates the feasibility of applying a systematic design technique and procedures for translating the ‘consumer’s voice’ into the design and technical specifications of a robotic tool carrier to be used in bioproduction