15 research outputs found
Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines
- Author
- C Hirota
- E Kopp
- E M J Boon
- EM Boon
- F M Giardiello
- FM Giardiello
- FM Giardiello
- FM Giardiello
- G Hawcroft
- G J A Offerhaus
- G Winde
- GA Piazza
- J J Keller
- JJ Keller
- JJ Keller
- K Schmeiser
- KP Nugent
- KW Kinzler
- L Picariello
- M Bienz
- M Cruz-Correa
- M Shtutman
- MF McEntee
- ML Smith
- MM Entius
- MT Spagnesi
- PJ Pasricha
- R Hanif
- R van der Neut
- RN DuBois
- S Dihlmann
- S T Pals
- SJ Baek
- SJ Shiff
- T A M Wormhoudt
- TC He
- WA Brown
- WJ Thompson
- X Zhang
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2004
- Field of study
Nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive potential against colorectal carcinomas (CRCs). Inhibition of cyclooxygenase (COX)-2 underlies part of this effect, although COX-2-independent mechanisms may also exist. Nonsteroidal anti-inflammatory drugs appear to inhibit the initial stages of the adenoma-carcinoma sequence, suggesting a link to the APC/beta-catenin/TCF pathway (Wnt-signalling pathway). Therefore, the effect of the NSAID sulindac on nuclear (nonphosphorylated) beta-catenin and beta-catenin/TCF-mediated transcription was investigated. Nuclear #946;-catenin expression was assessed in pretreatment colorectal adenomas and in adenomas after treatment with sulindac from five patients with familial adenomatous polyposis (FAP). Also, the effect of sulindac sulphide on beta-catenin/TCF-mediated transcription was studied. Adenomas of FAP patients collected after treatment with sulindac for up to 6 months showed less nuclear beta-catenin expression compared to pretreatment adenomas of the same patients. Sulindac sulphide abrogated beta-catenin/TCF-mediated transcription in the CRC cell lines DLD1 and SW480, and decreased the levels of nonphosphorylated beta-catenin. As a result, the protein levels of the positively regulated TCF targets Met and cyclin D1 were downregulated after sulindac treatment. This study provides in vivo and in vitro evidence that nuclear beta-catenin localisation and beta-catenin/TCF-regulated transcription of target genes can be inhibited by sulindac. The inhibition of Wnt-signalling provides an explanation for the COX-2-independent mechanism of chemoprevention by NSAID
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
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- Aimoniotou-Georgiou E
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- Akerman N
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- Akring I
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- Wang T
- Wang W
- Wang X-L
- Wang Y
- Wang Y
- Wang Z
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- Wang Z
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- Ward J
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- Watanabe Oliveira HR
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- Wendling PR
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- Wilscott-Davids C
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- Wong JY
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- Wong KWK
- Wong SM
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- Woon YL
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- Wright S
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- Wu C
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- Wu J
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- Wylie K
- Xia J
- Xia Y
- Xia Z-Y
- Xiao W
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- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
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- Yuan J
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- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
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- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
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- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors
- Author
- A Ristmäski
- BS Reddy
- C Creminon
- CE Eberhart
- CW Williams
- D Labayle
- FM Giardiello
- Jeon-Uk Lee
- K Fujimoto
- K Ohhashi
- Koji Fujimoto
- M Oshima
- M Takahashi
- M Tsujii
- Masayuki Imamura
- Michihiko Wada
- MJ Thun
- MJ Thun
- MT Spagnesi
- RJ Coffey
- RN DuBois
- RN DuBois
- Ryo Hosotani
- Ryuichiro Doi
- Sanae Nakajima
- Shoichiro Tsuji
- SL Kargman
- T Koshiba
- Takatomo Koshiba
- XH Liu
- Yoshiharu Miyamoto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis
- Author
- A Lerner
- AA Irving
- Angelo Pietro Femia
- AP Femia
- AP Femia
- AP Femia
- Augusto Giannini
- B Agarwal
- B Kim
- BS Reddy
- Cristina Luceri
- CV Rao
- CV Rao
- DE Corpet
- EJ Greenspan
- FM Giardiello
- FM Giardiello
- G Xu
- Giovanna Caderni
- GP Collett
- GP Collett
- HF Vasen
- HL Newmark
- HS Samaha
- JJ Johnson
- JM Amos-Landgraf
- K Yang
- M Cruz-Correa
- M Zeineldin
- Maura Lodovici
- MK Washington
- MT Spagnesi
- N Arber
- N Bhatnagar
- NN Mahmoud
- Paulo Victoria Soares
- PJ Pasricha
- S Reagan-Shaw
- SM Plummer
- W Park
- X Huang
- YH Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer
- Author
- A Paganini-Hill
- AD Muller
- B Morson
- BS Reddy
- CA Garay
- CE Eberhart
- CE Eberhart
- CS Williams
- CV Rao
- CW Heath Jr
- D Labayle
- DM Parkin
- DM Schreinemachers
- DM Schreinemachers
- DS Alberts
- E Giovannucci
- E Giovannucci
- EA Meade
- ER Fearon
- ER Greenberg
- FM Giardiello
- FM Giardiello
- G Gridley
- G Tsioulias
- GA Piazza
- GA Piazza
- GJ Tsioulias
- H Sano
- H Sheng
- H Sheng
- H Vainio
- II Peleg
- II Peleg
- J Cibere
- J Landenheim
- J Singh
- JA DiSario
- JE Muscat
- JE Muscat
- JR Vane
- KA Kune
- KP Nugent
- L Rosenberg
- L Rosenberg
- LJ Hixson
- LJ Hixson
- LJ Marnett
- LJ Marnett
- M Fukutake
- M Kauppi
- M Oshima
- M Tsujii
- M Tsujii
- M. M Taketo
- ME Martinez
- MJ Reeves
- MJ Thun
- MJ Wargovich
- MM Taketo
- MT Spagnesi
- N Arber
- Nadir Arber
- O Suh
- PH Gann
- PJ Pasricha
- R S Sandler
- Raymond N. DuBois
- RF Logan
- RN DuBois
- RN DuBois
- RN DuBois
- S Kargman
- S.J Winawer
- SJ Shiff
- SJ Shiff
- SJ Shiff
- SR Hamilton
- T Kudo
- T Sturmer
- TA Chan
- W Smalley
- W Smalley
- WR Waddell
- WR Waddell
- WR Waddell
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Chemoprevention of hereditary colon cancers: time for new strategies
- Author
- A Hallak
- AD Spigelman
- AG Thorson
- AK Samadi
- AP Femia
- ASoP Committee
- B Kim
- B Kortum
- CA Kotwall
- CD Lao
- D Colussi
- D Labayle
- Dennis J. Ahnen
- DJ Gouma
- DL Edelstein
- DR Lewis
- E Hawk
- EM Stoffel
- FL Meyskens Jr
- FM Giardiello
- FM Giardiello
- G Steinbach
- GM Petersen
- H Ishikawa
- HF Vasen
- HJ Bussey
- I Heo
- I Nishisho
- J Burn
- J Burn
- J Burn
- J Groden
- JA Baron
- JF Haanstra
- JG Dowty
- JJ DeCosse
- JM Amos-Landgraf
- JM Carethers
- KA van Balkom
- KM Schmeler
- KP Nugent
- KW Jasperson
- KW Kinzler
- L Fini
- L Moreira
- L Zhang
- Luigi Ricciardiello
- M Cruz-Correa
- M Oshima
- M Song
- MA Jenkins
- MA McIlhatton
- MD Johnson
- MH Kucherlapati
- MM Bertagnolli
- MM Taketo
- MT Spagnesi
- N Arber
- NJ Samadder
- NJ West
- O Itano
- OJ Sansom
- P Van Duijvendijk
- Patrick M. Lynch
- PM Lynch
- PM Lynch
- PM Lynch
- PM Rothwell
- R van Stolk
- RK Phillips
- RW Burt
- S Cohen
- SG Rajaratnam
- T Higuchi
- WA Klein
- WF Bodmer
- WM Grady
- WR Waddell
- WR Waddell
- X Wu
- Y Niv
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Role of Arachidonic Acid Regulatory Enzymes in Colorectal Disease
- Author
- A Bennett
- A Kornbluth
- A Lanas
- AC Rosam
- AH Tashjian Jr
- AJ Morris
- AT Chan
- AW Bak
- B Samuelsson
- BI Hirschowitz
- BI Hirschowitz
- BK Reuter
- CA Lesch
- CA Speed
- CC Leslie
- CE Eberhart
- CJ Hawkey
- CJ Hawkey
- CJ Hawkey
- CJ Woolverton
- CS Kaza
- CS Smith
- CW Hendrickse
- D Labayle
- D Rachmilewitz
- DJ Elder
- DM Schreinemachers
- DV Gopal
- E Giovannucci
- E Giovannucci
- E Smecuol
- EA Lobos
- F Karmeli
- FM Giardiello
- G Ara
- G Olaison
- G Olaison
- G Steinbach
- GD Hooker
- GF Bonner
- GJ Tsioulias
- GR Gibson
- H Allgayer
- H Berkel
- H Saito
- H Sano
- H Wang
- HE Mulcahy
- HR Herschman
- I Bjarnason
- I Bjarnason
- I Shureiqi
- I Shureiqi
- I Sobhani
- II Singer
- J Lang
- JA Baron
- JA Dominitz
- JA Smith
- JA Tangrea
- JB Felder
- JG Filep
- JL Wallace
- JL Wallace
- JL Wallace
- JL Wallace
- JL Wallace
- JL Wallace
- JL Williams
- JM Evans
- JR Vane
- JV Esplugues
- K Sperber
- K Takaku
- KH Hong
- KW Kinzler
- L Laine
- LA Garcia-Rodriguez
- LE LeDuc
- LL Stoll
- M Cruz-Correa
- M Murakami
- M Oshima
- M Pollard
- M Pollard
- M Snoj
- M Tsujii
- MC Allison
- MF Byrne
- MJ Thun
- MK Jones
- MM Wolfe
- MR Wright
- MS Phillips
- MT Spagnesi
- N Svartz
- NJ Shaheen
- NK Boughton-Smith
- NM Davies
- P Arvind
- P Emery
- P Sharon
- PA Janne
- R Eliakim
- RA Gupta
- RJ Spencer
- RS Sandler
- S Yamashita
- S Yamashita
- SB Hanauer
- SH Landis
- SJ Shiff
- SJ Shiff
- SL Kargman
- SL Parker
- SM Prescott
- T Abe
- T Kawamori
- TK Asano
- U Mahadevan
- W Smalley
- WM O’Brien
- WR Waddell
- Y Rayyan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Profiles of COX-2 inhibitors: present and future
- Author
- ABOU-ISSA HM
- AISEN PS
- ALYSON F
- BELTON
- BIAS P
- BIRBARA CA
- BOILEAU C
- BOMBARDIER C
- BOON EM
- BRATER DC
- BRATER DC
- CAMPBELL JA
- CANNON GW
- CATELLA-LAWSON F
- CATURLA F JIMENEZ J-M
- CHAN G
- CHENG Y
- CHOW LW WONG JL
- CHOY H
- Cl-JAN TA
- CSIKI I
- CURTIS SP
- DADIS TW O&
- DE LEVAL X
- DEGNER F
- DELIGEOROGLOU E
- DERKSEN E
- DEWITT DL
- DIXON DA
- DUBOIS RN
- EGAN KM
- EIBL G
- FARKOUH ME
- FIORUCCI S
- FISCHER SM
- FITZGERALD GA
- FLETCHER BS
- FU J-Y MASFERRER JL, SEIBERT K, RAZ A, NEEDLEMAN
- FUJITA T
- FUNKHOUSER EM
- GAMBARO G
- GASPARINI L
- GEIS GS
- GOLDENBERG MM
- GRETZER B
- GRUBBS CJ
- GUSTAFSON-SVARD C
- HABENICHT AJ
- HAN J-W SADOWSKI H, YOUNG
- HARRIS RE
- HARRIS RE
- HERNANSANZ MAC ROY RS, ORGAZ AC et al.
- HET-C CHAN TA
- HIDA T KOZAKI K-I
- HLA T
- HRACHOVEC JB
- HSU A-L CHING T-T, WANG
- IKEDA Y
- J
- KANIS JA
- KATZ N
- KAWAMORI T
- KEEBLE JE
- KELLSTEIN D
- KISMET K
- KRYMCHANTOWSKI AV
- KUBATKA P
- KUNE GA
- LANA A
- LASKIN JJ
- LEE JC
- LI J
- LIM GP
- LIU CH
- LOBO BL
- LYNCH PM
- MAGGOS C
- MAGGOS C
- MAIER TJ
- MALIMSTROM K
- MAREN TH
- MARTIN BK
- MASFERRER JL
- MCADAM BF
- MCCORMACK K
- MELK A
- MERCADANTE S
- MILAS L
- MUKHERJEE D
- MUNKARAH AR
- MUNKARAH AR
- NACHEMSON AL
- NAKATA E
- NAKATSUGI S
- O'BANION MK
- OSHIMA M
- PARAIVIASHIVAPPA R
- PATEL VA
- RANATUNGE RR
- RANATUNGE RR
- REUBEN SS
- RIENDEAU D
- RIOUX N
- RODRIGUEZ G
- ROSENBERG L
- ROSENBERG L
- ROSSAT J
- RUBINFELD B
- SABINO MA
- SAPER J
- SAWAOKA H
- SCALI C
- SCHREINEMACHERS DM
- SCHWAB JM
- SCOTT G
- SHENG H
- SHIOTANI H
- SIMMONS DL
- SINGH SK
- SINGH SK
- SPAGNESI MT
- SUBBARAIVIAIAH K
- SUBBARAMAIAH K
- SUBBARAMAIAH K
- SULK VOGELSTEIN
- SUPURAN CT
- TAYLOR DW
- TERRY MB
- THUN MJ
- THUN MJ
- TIANO HF
- TOMOZAWA S
- UDDIN JM RAO PNP
- VANE JR
- VANHOEFER U
- WALLACE JL
- WEAVER A
- WEBER A
- WEGGEN S
- WET M
- WHELTON A
- WHELTON A
- WILLIAMS CS
- YOSHIMURA R
- ZANDI PP
- ZHAO Y
- ZIMMERMANN KC
- Publication venue
- 'Informa Healthcare'
- Publication date
- Field of study
The Role of Inflammation in Colon Cancer
- Author
- A Goel
- A Mohammed
- A Tenesa
- A Ukil
- AF Cicero
- AJ Dannenberg
- AL Cheng
- AL Colon
- AM Westbrook
- AN Freedman
- AT Chan
- AT Gewirtz
- AV Nguyen
- B Ahn
- B Shpitz
- BD Goldstein
- BG Bhat
- BS Reddy
- BS Reddy
- BS Reddy
- C Bortuzzo
- C Vecchia La
- CC Ziegler
- CE Trebino
- CF Babbs
- CH Cottart
- CN Serhan
- CN Serhan
- CS Kwon
- CV Rao
- CV Rao
- CV Rao
- CV Rao
- CV Rao
- CV Rao
- CV Rao
- D Ahnen
- D Laybayle
- D Rachmilewitz
- D Wang
- DM Schreinemachers
- DS Alberts
- E Giovannucci
- E Giovannucci
- E Szaleczky
- EL Campbell
- ER Greenberg
- ET Hawk
- F Cannizzo Jr
- FE Silverstein
- FM Giardello
- FS Velayos
- G Bartosz
- G Calviello
- G Canny
- G Garcea
- G Haklar
- G Wan
- G Winde
- GA Orner
- GP Dunn
- H Hammad
- H Ohshima
- I Alfaras
- I Alfaras
- I Atreya
- I Atreya
- I Avis
- II Peleg
- IS Son
- J Askling
- J Claria
- J Liu
- J Martel-Pelletier
- J Raju
- J Raju
- J Rigau
- J Vanamala
- JA Baron
- JA Crowell
- JA Lagares-Garcia
- JE Muscat
- JF Ohd
- JL Goulet
- JR Brown
- KR Patel
- KT Nam
- L Laine
- L Qiao
- L Tessitore
- LA Feagins
- LB Meira
- LJ Hofseth
- LJ Marnett
- M Arita
- M Jang
- M Moorghen
- M Moorghen
- M Moreau
- M Oshima
- M Oshima
- M Oshima
- M Pollard
- M Pollard
- M Pollard
- M Sengottuvelan
- MA Al-Salihi
- MA Juarez-Oropeza
- MA McAnuff
- MD Boudreau
- MD Castellone
- ME Juan
- ME Juan
- ME Martinez
- MH Thun
- MJ Waldner
- MT Spagnesi
- MV Swamy
- N Nalini
- N Nieto
- N Pizato
- N Suh
- N Yagihashi
- NA Nussmeier
- NB Janakiram
- NB Janakiram
- NB Janakiram
- NN Mahmoud
- O Suh
- P Bansal
- P Belliveau
- P Bias
- P Cerutti
- P Piyachaturawat
- PC Chulada
- PC Chulada
- PL Lakatos
- R Schleiffer
- RA Gupta
- RA Sharma
- RA Sharma
- RC Mund
- RE Harris
- RF Jacoby
- RF Jacoby
- RF Logan
- RJ Griffiths
- RS Bresalier
- RS Byrum
- RS Sandler
- RW Waddel
- S Bajad
- S Darshan
- S Fiorucci
- S Sale
- S Tamir
- SB Mahato
- SD Solomon
- SE Erdman
- SF Oh
- SH Hong
- SK Boolbol
- T Ishida
- T Ishida
- T Kato
- T Kawamori
- T Kawamori
- T Kawamori
- T Kawamori
- T Kudo
- T Murata
- T Narisawa
- T Narisawa
- T Walle
- T Yamada
- U Metzger
- V Togni
- W Xu
- WE Smalley
- WG Tong
- WL Smith
- WL Smith
- XP Hao
- XZ Ding
- XZ Ding
- Y Abe
- Y Schneider
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study