Performance of taste enhancers mixed with cereal bases and evaluation of the most preferred bait composition for Bandicota bengalensis (Gray)

Baiting technique if appropriately applied is the most reliable strategy to control rodent pests. Behavior modifying components may play a significant role in developing the most attractive baits. An attempt was therefore made to investigate the behavior revolutionizing effect of taste enhancers including peanut oil, peanut butter, egg shell and fishmeal, on exploratory approaches of rodents. Precise role of additives and impact of particle size of cereal bases has been discussed aiming to minimize bait shyness, neophobia and development of the most preferred bait combination for effective control of bandicoot rat Bandicota bengalensis.Key words: Bandicota bengalensis, cereals baits, taste enhancers, shyness, neophobia

Capitalistic Gender Norms and Class Arrogance in Charles Dickens’s Great Expectations: A Marxist Analysis

This research paper seeks to examine the complex influence of capitalism on gender norms and the continuation of class arrogance in society, employing a Marxist analytical framework. This study aims to reveal the intricate mechanisms by which capitalism strengthens traditional gender norms and worsens class disparities by analyzing the interaction between economic systems, gender dynamics, and social hierarchies. Utilizing Marxist ideas of class conflict and exploitation, this paper examines how capitalist systems sustain gender disparity by assigning women to unpaid domestic work positions inside the household. Moreover, it will examine how the bourgeoisie's dominion over the means of production solidifies their authority and sustains class haughtiness, intensifying the marginalization of persons from lower social classes. Besides, this paper analyzes the ways in which characters in Charles Dickens' Great Expectations belonging to various social classes handle and internalize gender stereotypes and class boundaries through a careful examination. This analysis will specifically examine the experiences of female characters in the novel, including Mrs. Joe, Biddy, and Miss Havisham, in order to clarify how their identities and opportunities are influenced by capitalist ideology. The ultimate goal is to provide insight into the lasting impacts of capitalism and how they affect gender equality and class unity in today's society. Keywords: Marxism, Capitalism, Gender Roles, Class Arrogance, Social Hierarchy

Retinoblastoma and vision

The assessment of vision has a growing importance in the management of retinoblastoma in the era of globe-conserving therapy, both prior to and after treatment. As survival rates approach 98-99% and globe salvage rates reach ever-higher levels, it is important to provide families with information regarding the visual outcomes of different treatments. We present an overview of the role of vision in determining the treatment given and the impact of complications of treatment. We also discuss screening and treatment strategies that can be used to maximise vision

Sclero-conjunctival ischaemia secondary to intra-arterial chemotherapy for retinoblastoma

PURPOSE Intra-arterial chemotherapy (IAC), delivered directly to the globe via the internal carotid artery is now an established treatment for retinoblastoma. We report a case of anterior segment ischaemia following treatment with multiple intra-arterial chemotherapy (IAC) infusions. OBSERVATIONS A 5 month old female presented with bilateral retinoblastoma and was treated with 12 infusions of IAC. Her right eye was enucleated at diagnosis. After her seventh IAC treatment, she developed ipsilateral sixth and third cranial nerve palsies. After the twelfth IAC, she developed an area of conjunctival and scleral ischaemia between 12 and 3 o'clock meridians in her left eye. However, she maintained visual acuity of LogMAR 0.34. CONCLUSIONS AND IMPORTANCE The median number of IAC treatments in large studies is three. It is possible that repeated doses of IAC have an accumulative negative effect on the ocular blood supply, risking anterior segment and neurologic sequelae. This case highlights the significant challenge of balancing the salvage of eyes and vision with the potentially significant morbidity associated with IAC

Mechanistic Insight into the Reactivation of BCAII Enzyme from Denatured and Molten Globule States by Eukaryotic Ribosomes and Domain V rRNAs

In all life forms, decoding of messenger-RNA into polypeptide chain is accomplished by the ribosome. Several protein chaperones are known to bind at the exit of ribosomal tunnel to ensure proper folding of the nascent chain by inhibiting their premature folding in the densely crowded environment of the cell. However, accumulating evidence suggests that ribosome may play a chaperone role in protein folding events in vitro. Ribosome-mediated folding of denatured proteins by prokaryotic ribosomes has been studied extensively. The RNA-assisted chaperone activity of the prokaryotic ribosome has been attributed to the domain V, a span of 23S rRNA at the intersubunit side of the large subunit encompassing the Peptidyl Transferase Centre. Evidently, this functional property of ribosome is unrelated to the nascent chain protein folding at the exit of the ribosomal tunnel. Here, we seek to scrutinize whether this unique function is conserved in a primitive kinetoplastid group of eukaryotic species Leishmania donovani where the ribosome structure possesses distinct additional features and appears markedly different compared to other higher eukaryotic ribosomes. Bovine Carbonic Anhydrase II (BCAII) enzyme was considered as the model protein. Our results manifest that domain V of the large subunit rRNA of Leishmania ribosomes preserves chaperone activity suggesting that ribosome-mediated protein folding is, indeed, a conserved phenomenon. Further, we aimed to investigate the mechanism underpinning the ribosome-assisted protein reactivation process. Interestingly, the surface plasmon resonance binding analyses exhibit that rRNA guides productive folding by directly interacting with molten globule-like states of the protein. In contrast, native protein shows no notable affinity to the rRNA. Thus, our study not only confirms conserved, RNA-mediated chaperoning role of ribosome but also provides crucial insight into the mechanism of the process

Hematological and Biochemical Parameters of Pregnant and Lactating Goats in Rangeland of Cholistan Desert, Bahawalpur, Pakistan

Jattal goats (n=90) of approximately 2-6 years of age being reared in Cholistan desert of Pakistan were studied during January to December, 2015 to examine the alterations in hematochemical parameters of Jattal goats at different reproductive phases while feeding on natural vegetations of desert areas of Cholistan. These were divided into three equal groups (non-pregnant, pregnant and lactating). Blood samples were collected by jugular vein puncture from goats of these three groups. Hematological parameters, white blood cells (WBC), lymphocytes (LYM), monocytes (MON), granulocytes (GRA), red blood cells ( RBC), hemoglobin (Hb), hematocrit ( HCT), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration ( MCHC) and red cell distribution width RDW were recorded. The results obtained revealed that all these parameters were generally lower in non-pregnant goats. The study revealed that significant higher values of hemoglobin (Hb), mean cell hemoglobin (MCH) and mean corpuscular volume (MCV) were observed in the lactating goats (P<0.05). Pregnant goats showed a significantly (P<0.05) higher values of leucocytes (WBC) than lactating and non-pregnant goats. Plasma sodium (Na) and potassium (K) concentration were markedly lower in lactating goats. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly lower in pregnant goats. The Plasma concentration of cholesterol and triglycerides were higher in pregnant goats. In conclusion in present study changes in some hematochemical parameters have been determined in pregnant, non-pregnant and lactating goats of Jattal breed.Jattal goats (n=90) of approximately 2-6 years of age being reared in Cholistan desert of Pakistan were studied during January to December, 2015 to examine the alterations in hematochemical parameters of Jattal goats at different reproductive phases while feeding on natural vegetations of desert areas of Cholistan. These were divided into three equal groups (non-pregnant, pregnant and lactating). Blood samples were collected by jugular vein puncture from goats of these three groups. Hematological parameters, white blood cells (WBC), lymphocytes (LYM), monocytes (MON), granulocytes (GRA), red blood cells ( RBC), hemoglobin (Hb), hematocrit ( HCT), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration ( MCHC) and red cell distribution width RDW were recorded. The results obtained revealed that all these parameters were generally lower in non-pregnant goats. The study revealed that significant higher values of hemoglobin (Hb), mean cell hemoglobin (MCH) and mean corpuscular volume (MCV) were observed in the lactating goats (P<0.05). Pregnant goats showed a significantly (P<0.05) higher values of leucocytes (WBC) than lactating and non-pregnant goats. Plasma sodium (Na) and potassium (K) concentration were markedly lower in lactating goats. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly lower in pregnant goats. The Plasma concentration of cholesterol and triglycerides were higher in pregnant goats. In conclusion in present study changes in some hematochemical parameters have been determined in pregnant, non-pregnant and lactating goats of Jattal breed

Number, frequency and time interval of examinations under anesthesia in bilateral retinoblastoma

PURPOSE: Current practice in retinoblastoma (Rb) has transformed this malignancy into a curable disease. More attention should therefore be given to quality of life considerations, including measures related to examinations under anesthesia (EUAs). We aimed to investigate EUA measures in bilateral Rb patients and compare the findings to EUAs in unilateral Rb. METHODS: A retrospective analysis of bilateral Rb patients that presented to the London Rb service from 2006 to 2013, were treated and had long-term follow-up. RESULTS: A total of 62 Rb patients, 15 (24.2%) of which had International Intraocular Retinoblastoma Classification (IIRC) group A/B/no Rb at presentation, 26 (41.9%) C/D, and 21 (33.9%) were E in at least one eye. The mean number of EUAs was 35.8 ± 21.5, mean time from first to last EUA was 50.6 ± 19.9 months, and mean EUA frequency was 0.715 ± 0.293 EUAs/month. IIRC group was found not to correlate with any of the EUA measures. Age at presentation inversely correlated with time interval from first to last EUA and to EUA frequency (p ≤ 0.029). Rb family history correlated with the latter measure (p = 0.005) and intraophthalmic artery chemotherapy and brachytherapy correlated with all EUA measures (p ≤ 0.029). Mean follow-up time was 80.1 ± 24.3 months. When compared with a previously reported cohort of unilateral Rb, the present group underwent 3× more EUAs (p < 0.001) over nearly double the time (p < 0.001). CONCLUSIONS: Families should be counselled on anticipated EUA burden associated with bilateral Rb. In this respect, age at presentation and family history were found to have a predictive role, whereas IIRC group did not