Overground vs. Treadmill Running: Do Runners Use the Same Strategy to Adjust Stride Length and Frequency While Running at Different Velocities?

Running speed is determined by stride frequency and stride length. As running speed is adjusted, runners make greater adjustments in stride length at slower speeds with a shift to stride frequency adjustments at the faster speeds. The relationship between stride frequency and stride length is largely based on overground research which leads to the purpose of this study to analyze whether the connection of stride frequency and stride length will adjust similar due to changes in running velocity during overground and treadmill running. The protocol was recently approved by The Institutional Review Board and data collection is currently in progress; - thus the following present abstract does not contain data. In order to compare runner’s gait pattern responses to velocity changes, two wearable technologies (Garmin Fenix2, Garmin, Kansas, USA; runScribe, Scribe Lab, San Francisco, USA) designed to measure stride length and stride frequency will be utilized. Subjects will run at a variety of velocities overground and then on the treadmill with speeds ranging from slow, preferred, and fast. The main dependent variables will be stride frequency and stride length. The null hypothesis is: The relationship between stride length and stride frequency is similar while running overground and on a treadmill at different velocities. The results of this study will be helpful to runners as well as development of wearable technology used to quantify run metrics

ISOWN: accurate somatic mutation identification in the absence of normal tissue controls.

BackgroundA key step in cancer genome analysis is the identification of somatic mutations in the tumor. This is typically done by comparing the genome of the tumor to the reference genome sequence derived from a normal tissue taken from the same donor. However, there are a variety of common scenarios in which matched normal tissue is not available for comparison.ResultsIn this work, we describe an algorithm to distinguish somatic single nucleotide variants (SNVs) in next-generation sequencing data from germline polymorphisms in the absence of normal samples using a machine learning approach. Our algorithm was evaluated using a family of supervised learning classifications across six different cancer types and ~1600 samples, including cell lines, fresh frozen tissues, and formalin-fixed paraffin-embedded tissues; we tested our algorithm with both deep targeted and whole-exome sequencing data. Our algorithm correctly classified between 95 and 98% of somatic mutations with F1-measure ranges from 75.9 to 98.6% depending on the tumor type. We have released the algorithm as a software package called ISOWN (Identification of SOmatic mutations Without matching Normal tissues).ConclusionsIn this work, we describe the development, implementation, and validation of ISOWN, an accurate algorithm for predicting somatic mutations in cancer tissues in the absence of matching normal tissues. ISOWN is available as Open Source under Apache License 2.0 from https://github.com/ikalatskaya/ISOWN

Improving Proficiency in Central Venous Catheter Insertion: Standardized Simulation Based Training for Internal Medicine House Staff

Objectives: The objectives of this study are to assess residents\u27 pre-workshop ability and comfort with CVC placement, undergo a standardized online didactic and hands-on clinical training simulation workshop, and subsequently undergo a proficiency test using simulation models to assess competency. The goal of a standardized training module is to create a universal approach to CVC placement in our institution and improve comfort and technical ability of house staff. We hypothesize that this will reduce complications and improve patient care and safety.https://jdc.jefferson.edu/patientsafetyposters/1063/thumbnail.jp

The Association Between Opioid-Related Industry Payments and Opioid Prescribing at the Individual and Ecological Level in Pennsylvania

Objective: to understand how industry payments related to opioid products are associated with opioid prescribing in Pennsylvania. Methods: we merged the Open Payments data, Medicare Part D public use file, and Dartmouth Hospital Atlas of Health Care Hospital Service Areas from 2015 to analyze relationships between opioid related payments and opioid prescribing. We used a binomial regression model to investigate individual-level trends and a log-linear model to investigate Hospital Service Area-level trends. We mapped the distribution of opioid-related payments in Pennsylvania using GIS software. Results: One additional payment to a physician was associated with 4.2% higher opioid-prescribing rate (OR = 1.0418, 95% CI 1.0416-1.0420, Chi-Square(1) = 122678, p Conclusions: We found a positive association between opioid-related payments to physicians and opioid prescribing. Policy makers and administrators should consider revising rules related to pharmaceutical company marketing tactics and promote judicious opioid prescribing

The Role of Rural Hospitals in Addressing Opioid and Other Substance Use Problems

Webinar presentation to the Small Rural Hospital Transition project addressing issues of rural opioid and other substance use issues, focusing on the role of rural hospitals, and the importance of community engagement. Component parts of an effective opioid/substance use system of care include prevention, treatment, and recovery. Models must be adapted to the geographic, resource, and cultural realities of rural areas. Examples of strategies are provided

Strategies to Combat Opioid Use in Rural Communities

Webinar presentation discussing Opioid use across rural settings Drivers of rural opioid use Burden of opioid use in rural communities Evidence-based prevention, treatment, and recovery strategies to address rural opioid us

Rural America: A look beyond the images

The issues faced by patients and providers in rural health care differ greatly from those of urban counterparts. They also differ across rural communities. Understanding these differences, and the differences among rural populations across America, is critical to providing health services to rural Americans, who are often impeded by economic factors, cultural and social differences, educational shortcomings and isolation in their efforts to lead normal, healthy lives. The challenges provide opportunities for Catholic health care to make a difference in the lives and health of some of the nation\u27s most vulnerable citizens

Prevention of Drug Use and Treatment of Drug Use Disorders in Rural Settings

This Guide on Prevention of Drug Use and Treatment of Drug Use Disorders in Rural Settings was prepared by the United Nations Office on Drugs and Crime (UNODC) Drug Prevention and Health Branch (DHB), in the context of the global project Treatnet II: OFID-UNODC Programme to prevent HIV/AIDS through Treatnet Phase II, with the aim of providing an awareness-raising tool and guidance for policymakers, public health officials, local authorities and other stakeholders in dealing with substance use issues in rural settings in their respective countries. This Guide will serve as an awareness-raising tool and guidance for policymakers, public health officials, local authorities and other stakeholders in dealing with substance use issues in rural settings in their respective countries. It will “set the stage” for the identification, assessment, planning and implementation of both prevention interventions and policies, as well as interventions targeting rural drug users, by: Describing substance use problems in rural settings and factors contributing to them. Identifying tools that can be used to assess the scope of rural substance use in their countries. Describing evidence-based prevention, treatment and recovery strategies that can be implemented in rural areas. Providing examples of successful promising and evidence-based strategies implemented in diverse rural areas worldwide. This Guide is intended to be shared widely with policymakers and other stakeholders concerned with the problems of substance use in rural settings. It provides an understanding of several key economic and social disparities driving rural substance use and the barriers to treatment experienced by rural people with substance use disorders

Barriers to Exercise: Fitness Made Simple

Lifestyle modification is a necessary component of managing chronic illnesses in order to obtain the best outcomes. Exercise has been shown to be efficacious at improving outcomes in a number of different clinical contexts. Patient adherence to exercise as a lifestyle modification is lower than desired due to multifactorial etiology including socioeconomic constraints, disability, chronic pain, and motivation. This project attempts to address all four with a site specific educational pamphlet