95 research outputs found

    Overscreening Diamagnetism in Cylindrical Superconductor-Normal Metal-Heterostructures

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    We study the linear diamagnetic response of a superconducting cylinder coated by a normal-metal layer due to the proximity effect using the clean limit quasiclassical Eilenberger equations. We compare the results for the susceptibility with those for a planar geometry. Interestingly, for RdR\sim d the cylinder exhibits a stronger overscreening of the magnetic field, i.e., at the interface to the superconductor it can be less than (-1/2) of the applied field. Even for RdR\gg d, the diamagnetism can be increased as compared to the planar case, viz. the magnetic susceptibility 4πχ4\pi\chi becomes smaller than -3/4. This behaviour can be explained by an intriguing spatial oscillation of the magnetic field in the normal layer

    Rho GTPase activating protein 21-mediated regulation of prostate cancer associated 3 gene in prostate cancer cell

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    The overexpression of the prostate cancer antigen 3 (PCA3) gene is well-defined as a marker for prostate cancer (PCa) diagnosis. Although widely used in clinical research, PCA3 molecular mechanisms remain unknown. Herein we used phage display technology to identify putative molecules that bind to the promoter region of PCA3 gene and regulate its expression. The most frequent peptide PCA3p1 (80%) was similar to the Rho GTPase activating protein 21 (ARHGAP21) and its binding affinity was confirmed using Phage Bead ELISA. We showed that ARHGAP21 silencing in LNCaP prostate cancer cells decreased PCA3 and androgen receptor (AR) transcriptional levels and increased prune homolog 2 (PRUNE2) coding gene expression, indicating effective involvement of ARHGAP21 in androgen-dependent tumor pathway. Chromatin immunoprecipitation assay confirmed the interaction between PCA3 promoter region and ARHGAP21. This is the first study that described the role of ARHGAP21 in regulating the PCA3 gene under the androgenic pathway, standing out as a new mechanism of gene regulatory control during prostatic oncogenesis

    Destacadas de soja (Glycine max (L.) merril absorção de cálcio e fósforo por raízes var. IAC-2)

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    This paper deals with experiments designed to study the influence of several external factors on the uptake both of Ca+² and H2PO4 - by excised soybean roots. The main conclusions are as follows: 1) Ca uptake does not follow the usual Michaelian kynetics, the evidence suggesting the operation of passive mechanism; 2) R uptake is metabolic, a single mechanism being in operation; 3) pH has a strong effect both on Ca and R absorption; 4) The use both of lower temperature (O0C) and of respiratory poisons (cyanide) inibited phosphate uptake but had no effect on calcium absorption. 5) The obsorption of Ca+2 was lowered in the presence of Mg+² but not in that of K+; nitrate ions had no detrimental or sinergistic offect on the absorption of phosphate.A absorção do cálcio e do fósforo por raízes destacadas da soja var. IAC-2 foi estudada com ajuda de traçadores. Foram verificados os efeitos da concentração iônica externa do tempo, do pH, da temperatura, da aeração e de venenos respiratórios. Os dados sugerem que a absorção do cálcio tenha se dado passivamente, sendo ativa a do fósforo. A absorção cresceu com o pH e a temperatura. Os valores das constantes de Michaelis encontrados concordam com os da literatura
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