Rubin-Euclid Derived Data Products:Initial Recommendations

This report is the result of a joint discussion between the Rubin and Euclid scientific communities. The work presented in this report was focused on designing and recommending an initial set of Derived Data products (DDPs) that could realize the science goals enabled by joint processing. All interested Rubin and Euclid data rights holders were invited to contribute via an online discussion forum and a series of virtual meetings. Strong interest in enhancing science with joint DDPs emerged from across a wide range of astrophysical domains: Solar System, the Galaxy, the Local Volume, from the nearby to the primaeval Universe, and cosmology

Experimental and theoretical study of high frequency magnetic fields around a railway track

The South African railway company makes use of a train wheel detection system to monitor the trains present on a particular track, noting their lengths, positions and speeds. Interference due to distorted traction currents cause havoc with this system rendering the information gathered unreliable. To combat this interference two paths are available to reduce the detection systems susceptibility. These paths include the addition of shielding between the railway track and the wheel detectors, which form the functional entities of the train wheel detection system, and the installation of a cable running parallel to the railway track with connections to it some distance before and after the position of the wheel detector. To verify these paths, high frequency experiments were performed in the lab as well as FEM simulations. To perform the high frequency experiments a source capable of producing the high frequency current needed was designed and constructed, along with a well shielded measurement system to enable the mapping of the flux density within the region occupied by and surrounding the wheel detector. The results of both the experimental measurements and simulations yielded that the interfering magnetic field could indeed be reduced through the use of the two available paths, when they are both applied separately and in combination. To obtain the greater reduction in the interfering field within the area occupied by and surrounding the wheel detector the paths should be used in combination. Therefore through the use of a shield that is constructed from a magnetic material and the installation of a parallel cable the train wheel detection system can be made more robust.Prof. W.A Cronjé Prof. I.W. Hofsaje

PEEC modeling of planar spiral resonators

The partial element equivalent circuit (PEEC) method is applied to a frequency-sweep study for investigating the resonant modes of planar spiral resonators. A low-rank approximation algorithm, based on hierarchical matrices, is coupled to the method in order to reduce the computational effort due to the use of dense matrices. The partitioning of the matrices is carefully addressed in order to allow an efficient hierarchical off-diagonal low-rank structure of the system matrix

Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria

Translocator protein 18 kDa [TSPO or peripheral-type benzodiazepine receptor (PBR)] was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions. In these areas, binding sites for TSPO ligands were recognized in steroid-producing tissues. TSPO plays an important role in many cellular functions, and its coding sequence is highly conserved across species. TSPO is located predominantly on the membrane of mitochondria and is overexpressed in several solid cancers. TSPO basal expression in the CNS is low, but it becomes high in neurodegenerative conditions. Thus, TSPO constitutes not only as an outstanding drug target but also as a valuable marker for the diagnosis of a number of diseases. The aim of the present article is to show the lesson we have learned from our activity in TSPO medicinal chemistry and in approaching the targeted delivery to mitochondria by means of TSPO ligands

Radiosynthesis and preliminary biological evaluation of [18F]VC701, a radioligand for translocator protein. G. Di Grigoli, C. Monterisi, S. Belloli, V. Masiello, L. S. Politi, S. Valenti, M. Paolino, M. Anzini, M. Matarrese, A. Cappelli, R.M. Moresco

Positron emission tomography (PET) can be used to monitor in vivo translocator protein (TSPO) expression by using specific radioligands. Recently, several [11C]PK11195 analogues have been synthesized to improve binding stability and brain availability. [18F]VC701 was synthesized and validated in CD healthy rats by biodistribution and inhibition analysis. Imaging studies were also conducted on animals injected unilaterally in the striatum with quinolinic acid (QA) to evaluate the TSPO ligand uptake in a neuroinflammation/neurodegenerative model. [18F]VC701 was synthesized with a good chemical and radiochemical purity and specific activity higher than 37 GBq/mmol. Kinetic studies performed on healthy animals showed the highest tracer biodistribution in TSPO-rich organs, and preadministration of cold PK11195 caused an overall radioactivity reduction. Metabolism studies showed the absence of radio metabolites in the rat brain of QA lesioned rats, and biodistribution analysis revealed a progressive increase in radioactivity ratios (lesioned to nonlesioned striatum) during time, reaching an approximate value of 5 4 hours after tracer injection. These results encourage further evaluation of this TSPO radioligand in other models of central and peripheral diseases