247 research outputs found
Age estimation using tooth cementum annulations: bias and sources of inaccuracy
Background: Counting the tooth cementum annulations (TCA) is a method for estimating the age at death of adults by sections of their tooth root. The objective of this study was to assess the precision of counting the cementum incremental lines and the congruence between known age and age estimates. Possible factors affecting the accuracy of the estimate were also analyzed. Methods: A sample of 67 permanent teeth extracted from individuals with known age (18 84 years) and sex was analyzed to calculate the dental age. Results: Results demonstrate an excellent inter- and intra-observer reliability of annuli counting, with dissimilarities within the limits of agreement. A moderate positive correlation was found between chronological age and TCA. Our results showed that age congruence rates differed across age groups (85% congruence in individuals <= 30 years; 75% in individuals aged 31-60 years; 60% in the over 60s). Considering the bias, this method showed a clear tendency to underestimate age in specimens from old people. After age 43, the TCA estimate is highly inaccurate exceeding the underestimation of 10 years, on average, in comparison to the chronological age. Both chronological age and dental arch seem to influence the accuracy of estimates, unlike sex and the tooth root number. Conclusions: TCA analysis is characterized by high precision and low accuracy, decreasing with age. Therefore, its applicability is limited in elderly subjects. The choice of methods for age estimation in adult skeletal remains should take into account the particular age range of individuals. We recommend using different age estimation methods to verify the reliability of the performed assessments
Dzyaloshinskii-Moriya interaction in transport through single molecule transistors
The Dzyaloshinskii-Moriya interaction is shown to result in a canting of
spins in a single molecule transistor. We predict non-linear transport
signatures of this effect induced by spin-orbit coupling for the generic case
of a molecular dimer. The conductance is calculated using a master equation and
is found to exhibit a non-trivial dependence on the magnitude and direction of
an external magnetic field. We show how three-terminal transport measurements
allow for a determination of the coupling-vector characterizing the
Dzyaloshinskii-Moriya interaction. In particular, we show how its orientation,
defining the intramolecular spin chirality, can be probed with ferromagnetic
electrodes
Pioglitazone Improves Myocardial Blood Flow and Glucose Utilization in Nondiabetic Patients With Combined Hyperlipidemia A Randomized, Double-Blind, Placebo-Controlled Study
ObjectivesThis study’s aim was to examine whether treatment with pioglitazone, added to conventional lipid-lowering therapy, would improve myocardial glucose utilization (MGU) and blood flow (MBF) in nondiabetic patients with familial combined hyperlipidemia (FCHL).BackgroundThiazolidinediones were found to improve insulin sensitivity and MGU in type 2 diabetes and MBF in Mexican Americans with insulin resistance. Familial combined hyperlipidemia is a complex genetic disorder conferring a high risk of premature coronary artery disease, characterized by high serum cholesterol and/or triglyceride, low high-density lipoprotein (HDL) cholesterol, and insulin resistance.MethodsWe undertook a randomized, double-blind, placebo-controlled study in 26 patients with FCHL, treated with pioglitazone or matching placebo 30 mg daily for 4 weeks, followed by 45 mg daily for 12 weeks. Positron emission tomography was used to measure MBF at rest and during adenosine-induced hyperemia and MGU during euglycemic hyperinsulinemic clamp at baseline and after treatment.ResultsWhereas no change was observed in the placebo group after treatment, patients receiving pioglitazone showed a significant increase in whole body glucose disposal (3.93 ± 1.59 mg/kg/min to 5.24 ± 1.65 mg/kg/min; p = 0.004) and MGU (0.62 ± 0.26 μmol/g/min to 0.81 ± 0.14 μmol/g/min; p = 0.0007), accompanied by a significant improvement in resting MBF (1.11 ± 0.20 ml/min/g to 1.25 ± 0.21 ml/min/g; p = 0.008). Furthermore, in the pioglitazone group HDL cholesterol (+28%; p = 0.003) and adiponectin (+156.2%; p = 0.0001) were increased and plasma insulin (−35%; p = 0.017) was reduced.ConclusionsIn patients with FCHL treated with conventional lipid-lowering therapy, the addition of pioglitazone led to significant improvements in MGU and MBF, with a favorable effect on blood lipid and metabolic parameters. (A study to investigate the effect of pioglitazone on whole body and myocardial glucose uptake and myocardial blood flow/coronary vasodilator reserve in patients with familial combined hyperlipidaemia; http://www.controlled-trials.com/mrct/trial/230761/ISRCTN78563659; ISRCTN78563659
Atypical audiovisual speech integration in infants at risk for autism
The language difficulties often seen in individuals with autism might stem from an inability to integrate audiovisual information, a skill important for language development. We investigated whether 9-month-old siblings of older children with autism, who are at an increased risk of developing autism, are able to integrate audiovisual speech cues. We used an eye-tracker to record where infants looked when shown a screen displaying two faces of the same model, where one face is articulating/ba/and the other/ga/, with one face congruent with the syllable sound being presented simultaneously, the other face incongruent. This method was successful in showing that infants at low risk can integrate audiovisual speech: they looked for the same amount of time at the mouths in both the fusible visual/ga/− audio/ba/and the congruent visual/ba/− audio/ba/displays, indicating that the auditory and visual streams fuse into a McGurk-type of syllabic percept in the incongruent condition. It also showed that low-risk infants could perceive a mismatch between auditory and visual cues: they looked longer at the mouth in the mismatched, non-fusible visual/ba/− audio/ga/display compared with the congruent visual/ga/− audio/ga/display, demonstrating that they perceive an uncommon, and therefore interesting, speech-like percept when looking at the incongruent mouth (repeated ANOVA: displays x fusion/mismatch conditions interaction: F(1,16) = 17.153, p = 0.001). The looking behaviour of high-risk infants did not differ according to the type of display, suggesting difficulties in matching auditory and visual information (repeated ANOVA, displays x conditions interaction: F(1,25) = 0.09, p = 0.767), in contrast to low-risk infants (repeated ANOVA: displays x conditions x low/high-risk groups interaction: F(1,41) = 4.466, p = 0.041). In some cases this reduced ability might lead to the poor communication skills characteristic of autism
Joule-assisted silicidation for short-channel silicon nanowire devices
We report on a technique enabling electrical control of the contact
silicidation process in silicon nanowire devices. Undoped silicon nanowires
were contacted by pairs of nickel electrodes and each contact was selectively
silicided by means of the Joule effect. By a realtime monitoring of the
nanowire electrical resistance during the contact silicidation process we were
able to fabricate nickel-silicide/silicon/nickel- silicide devices with
controlled silicon channel length down to 8 nm.Comment: 6 pages, 4 figure
Multifunctional Devices and Logic Gates With Undoped Silicon Nanowires
We report on the electronic transport properties of multiple-gate devices
fabricated from undoped silicon nanowires. Understanding and control of the
relevant transport mechanisms was achieved by means of local electrostatic
gating and temperature dependent measurements. The roles of the source/drain
contacts and of the silicon channel could be independently evaluated and tuned.
Wrap gates surrounding the silicide-silicon contact interfaces were proved to
be effective in inducing a full suppression of the contact Schottky barriers,
thereby enabling carrier injection down to liquid-helium temperature. By
independently tuning the effective Schottky barrier heights, a variety of
reconfigurable device functionalities could be obtained. In particular, the
same nanowire device could be configured to work as a Schottky barrier
transistor, a Schottky diode or a p-n diode with tunable polarities. This
versatility was eventually exploited to realize a NAND logic gate with gain
well above one.Comment: 6 pages, 5 figure
Low charge noise quantum dots with industrial CMOS manufacturing
Silicon spin qubits are among the most promising candidates for large scale
quantum computers, due to their excellent coherence and compatibility with CMOS
technology for upscaling. Advanced industrial CMOS process flows allow
wafer-scale uniformity and high device yield, but off the shelf transistor
processes cannot be directly transferred to qubit structures due to the
different designs and operation conditions. To therefore leverage the know-how
of the micro-electronics industry, we customize a 300mm wafer fabrication line
for silicon MOS qubit integration. With careful optimization and engineering of
the MOS gate stack, we report stable and uniform quantum dot operation at the
Si/SiOx interface at milli-Kelvin temperature. We extract the charge noise in
different devices and under various operation conditions, demonstrating a
record-low average noise level of 0.61 eV/ at 1 Hz and even
below 0.1 eV/ for some devices and operating conditions. By
statistical analysis of the charge noise with different operation and device
parameters, we show that the noise source can indeed be well described by a
two-level fluctuator model. This reproducible low noise level, in combination
with uniform operation of our quantum dots, marks CMOS manufactured MOS spin
qubits as a mature and highly scalable platform for high fidelity qubits.Comment: 22 pages, 13 figure
Argon milling induced decoherence mechanisms in superconducting quantum circuits
The fabrication of superconducting circuits requires multiple deposition,
etch and cleaning steps, each possibly introducing material property changes
and microscopic defects. In this work, we specifically investigate the process
of argon milling, a potentially coherence limiting step, using niobium and
aluminum superconducting resonators as a proxy for surface-limited behavior of
qubits. We find that niobium microwave resonators exhibit an order of magnitude
decrease in quality-factors after surface argon milling, while aluminum
resonators are resilient to the same process. Extensive analysis of the niobium
surface shows no change in the suboxide composition due to argon milling, while
two-tone spectroscopy measurements reveal an increase in two-level system
electrical dipole moments, indicating a structurally altered niobium oxide
hosting larger two-level system defects. However, a short dry etch can fully
recover the argon milling induced losses on niobium, offering a potential route
towards state-of-the-art overlap Josephson junction qubits with niobium
circuitry.Comment: Main text: 6 pages, 3 figures, 1 table. 5 appendices, with 6
additional figures and 3 additional tables. 62 reference
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