Pengalaman Ibu Dalam Pelaksanaan Perawatan Metode Kanguru Di Rumah Terhadap Bayi Berat Badan Lahir Rendah Di Wilayah Kerja Puskesmas Parongpong Kabupaten Bandung Barat

Introduction: : Kangaroo Care (Kangaroo Mother Care) is a treatment for low birth weight baby or infants born prematurely with contact the skin between baby and mother's skin or skin to skin contact, which is body temperature can be spark the baby. Objective: this study aims to identify the mother's experience over the treatment method of kangaroo in the house for low birth weight in the work area of the Puskesmas Parongpong West Bandung. Method: this research is a qualitative phenomenology which involved three Key Informants using proposive sampling technique with criteria experienced using kangaroo care at home for baby with low birth weight. The data collected through indepth interview, which is equipped with the guidelines interview. The interview recorded and transcript to using verbatim and analyzed by the method of Collaizzi. Results: there are three themes and twelve categories merges in this study. Discussion: this study provided advice for mothers, the family's health to support mothers with LBW in implementing the PMK and to guide further research for the wide research field of research

Pengaruh Pemberian Air Perasan Buah Mengkudu (Morinda Citrifolia) terhadap Penurunan Tekanan Darah pada Penderita Hipertensi

Hypertension is an abnormal increase in blood pressure in arterial blood vessels continuously for more than one period. This occurs when the arterioles are constricting. Arteriole constriction makes blood difficult to flow and increases pressure against arterial walls. The prevalence of hypertension in West Sumatra province reaches 21.4%. Data from the Provincial Health Office of West Sumatra in 2017 hypertension is the 10 most common diseases suffered by the community with 69,500 people suffering from hypertension. Pharmacological therapies available for hypertension have not shown improvement in reducing blood pressure in hypertensive patients. Very necessary companion therapy that is non-pharmacological treatment is expected to be able to complete pharmacological treatment in reducing blood pressure by using noni juice juice (Morinda Citrifolia).This study used the design of Quasy Experiment with the approach of group pretest posttest design. This research was carried out in the Belimbing Health Center Working Area The number of samples in this study were 10 respondents with purposive sampling technique. Data analysis in this study using univariate and bivariate using dependent t-test. The results obtained, the average systolic blood pressure of 12 mmHg with a value (p Value 0,000) and diastolic 5 mmHg (p Value 0.015) means that there is an influence on the average blood pressure before and after being given Noni juice.Based on the results of the research that has been obtained, it is expected that health workers through the head of the Puskesmas can apply or use Noni fruit juice as an alternative treatment for hypertension

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

Phosphoinositide 3-kinase δ (PI3Kδ) has a key role in lymphocytes, and inhibitors that target this PI3K have been approved for treatment of B cell malignancies1-3. Although studies in mouse models of solid tumours have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumour immunity4,5, its effect on solid tumours in humans remains unclear. Here we assessed the effects of the PI3Kδi AMG319 in human patients with head and neck cancer in a neoadjuvant, double-blind, placebo-controlled randomized phase II trial (EudraCT no. 2014-004388-20). PI3Kδ inhibition decreased the number of tumour-infiltrating regulatory T (Treg) cells and enhanced the cytotoxic potential of tumour-infiltrating T cells. At the tested doses of AMG319, immune-related adverse events (irAEs) required treatment to be discontinued in 12 out of 21 of patients treated with AMG319, suggestive of systemic effects on Treg cells. Accordingly, in mouse models, PI3Kδi decreased the number of Treg cells systemically and caused colitis. Single-cell RNA-sequencing analysis revealed a PI3Kδi-driven loss of tissue-resident colonic ST2 Treg cells, accompanied by expansion of pathogenic T helper 17 (TH17) and type 17 CD8+ T (TC17) cells, which probably contributed to toxicity; this points towards a specific mode of action for the emergence of irAEs. A modified treatment regimen with intermittent dosing of PI3Kδi in mouse models led to a significant decrease in tumour growth without inducing pathogenic T cells in colonic tissue, indicating that alternative dosing regimens might limit toxicity

Probing strongly interacting W's at the ILC with polarized beams

We study the possibility of fingerprinting a strongly interacting $W$ boson sector which is consistent with present day LHC searches at the ILC with longitudinal as well as transversely polarized electron and positron beams. We account for the final state interaction using a suitable Omn\`es formalism in terms of a plausible resonance description, and carry out thorough analyses of cross sections, asymmetries and angular distributions of the $W's$. We carry out a comparison with other extensions of the Standard Model, where heavy additional $Z'$ bosons arise naturally. We also consider the effect of the strong final state interaction on a correlation that depends on $(\phi_--\phi_+)$, where the $\phi_\mp$ are the azimuthal angles of decay leptons, and find that it is a useful discriminant.Comment: 25 pages latex using JHEP style files, 14 figures; v2 is a slightly expanded version of v1, reference added, discussions improved, some figures have been changed; corresponds to version accepted for publication in JHE

Controversial issues in the management of hyperprolactinemia and prolactinomas : an overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience