769 research outputs found

    Aggregation patterns of macroendoparasites in phylogenetically related fish hosts

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    doi:10.1017/ S0031182010000491Macroparasites are generally aggregated within their hosts with infection and aggregation levels resulting from a continuous arms race between maintaining high mating probability and host mortality low for which host and environmentally related factors contribute to some extent. Here, infection and aggregation patterns of the macroendoparasites infecting the flatfish Citharus linguatula, Arnoglossus laterna, Lepidorhombus boscii, Scophthalmus rhombus and Platichthys flesus in 3 areas along the Portuguese coast were analysed. Of the 21 macroendoparasite species found only 1 infected all hosts and most were host or area exclusive. For each host-parasite system, values of the indices varied between areas and macroendoparasites were not always aggregated; in fact, some macroendoparasites were generally uniformly distributed, which can be related to specific density-dependent regulation mechanisms. No general pattern was found for infection or aggregation levels of the 3 species infecting more than 2 hosts along the Portuguese coast, i.e. Lecithochirium rufoviride, Nybelinia lingualis and Anisakis simplex s.l., suggesting that regulation mechanisms are not species specific but are locally determined, with host ecology playing a significant role

    Maternal smoking: a life course blood pressure determinant?

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    Introduction: Exposure to maternal smoking early in life may affect blood pressure (BP) control mechanisms. We examined the association between maternal smoking (before conception, during pregnancy, and 4 years after delivery) and BP in preschool children. Methods: We evaluated 4295 of Generation XXI children, recruited at birth in 2005–2006 and reevaluated at the age of 4. At birth, information was collected by face-to-face interview and additionally abstracted from clinical records. At 4-year follow-up, interviews were performed and children’s BP measured. Linear regression models were fitted to estimate the association between maternal smoking and children’s BP. Results: Children of smoking mothers presented significantly higher BP levels. After adjustment for maternal education, gestational hypertensive disorders, and child’s body mass index, children exposed during pregnancy to maternal smoking presented a higher systolic BP (SBP) z-score (β = 0.08, 95% confidence interval [CI] 0.04 to 0.14). In crude models, maternal smoking was associated with higher SBP z-score at every assessed period. However, after adjustment, an attenuation of the association estimates occurred (β = 0.08, 95% CI 0.03 to 0.13 before conception; β = 0.07, 95%CI 0.02 to 0.12; β = 0.04, 95%CI −0.02 to 0.10; and β = 0.06, 95%CI 0.00 to 0.13 for the first, second, and third pregnancy trimesters, respectively; and β = 0.07, 95%CI 0.02 to 0.12 for current maternal smoking). No significant association was observed for diastolic BP z-score levels. Conclusion: Maternal smoking before, during, and after pregnancy was independently associated with systolic BP z-score in preschool children. This study provides additional evidence to the public health relevance of maternal smoking cessation programs if early cardiovascular health of children is envisaged. Implications: Using observational longitudinal data from the birth cohort Generation XXI, this study showed that exposure to maternal smoking—before pregnancy, during pregnancy, and 4 years after delivery—was associated with a systolic BP-raising effect in children at the age of 4. The findings of this study add an important insight into the need to support maternal smoke-free environments in order to provide long-term cardiovascular benefit, starting as early as possible in life.Generation XXI has been funded by the Operational Health Programme XXI Health, Community support framework III (co-funded by Feder), Administração Regional de Saúde do Norte, Fundação Calouste Gulbenkian and Fundação para a Ciência e Tecnologia (SFRH/BSAB/113778/2015; PD/BD/105824/2014; PD/BD/105827/2014; F-COMP-01-0124-FEDER-011008; FCT—PTDC/SAU-ESA/105033/2008). Also, the Portuguese Foundation for Science and Technology funds the Epidemiology Research Unit of the Institute of Public Health of the University of Porto (UID/DTP/04750/2013). This article is a result of the project DOCnet (NORTE-01-0145-FEDER-000003), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)

    Valuing travel time changes: a case of short-term or long-term choices?

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    The valuation of travel time is of crucial importance in many transport decisions. Most studies make use of data framed around short-term decisions such as route choice. However, people may have a greater ability to trade time and money in a longer term setting, such as when considering changes in residential or employment locations. We study the value of travel time in both the short and long-term, finding differences in the valuations. Given the importance of these valuations for policy making, our results call for more research into how time-cost trade-offs should be represented with stated preference

    Orbitopatia tiroideia

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    Cryptic species of Didymobothrium rudolphii (Cestoda : Spathebothriidea) from the sand sole, Solea lascaris, off the Portuguese coast, with an analysis of their molecules, morphology, ultrastructure and phylogeny

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    Didymobothrium rudolphii (Cestoda: Spathebothriidea) was collected seasonally from the sand sole, Solea lascaris, off the northern, central and Southern areas of the Portuguese coast. Morphological and molecular analyses were conducted in order to examine the possible existence of cryptic species and to facilitate the circumscription of their morphological boundaries. Data were compared between D. rudolphii specimens from each of the 3 geographical areas and 4 seasons, and principal components analysis of 18 morphological characters was used to detect differences. Two distinct genotypes were present with sequence divergences of 1 center dot 9%. and 2 center dot 1%, in the large Subunit (lsrDNA) and second internal transcribed spacer (ITS-2) of ribosomal DNA (rDNA), respectively. The less common 'central' genotype was present only off the central area from summer to winter, whereas the 'common' genotype was present throughout the year off the northern and southern areas, but only during spring in the central area, No sequence variation was found within each genotype. The presence of 2 distinct genetic entities was supported by morphological analyses, which showed the 'central' genotype specimens to be more slender and elongate, although morphometric ranges overlapped considerably for most characters. Molecular phylogenetic analysis of 4 of the 3 known genera of the Spathebothriidea showed Spathebothrium to be the earliest branching lineage and the 2 genotypes of Didymobothrium formed a sister group to Cyathocephalus. The concordance of genetic differences with variation in host diet according to season and locality could account for sympatric speciation occurring in the central region of the Portuguese coast

    Forma atipica de apresentacao de febre mediterrânica familiar

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    A Febre Mediterrânica Familiar (FMF) é uma doença hereditária autossómica recessiva caracterizada por episódios de febre recorrente, artrite e poliserosite – peritonite, pleurite e/ou pericardite. A sua principal complicação é a amiloidose AA sistémica. Menina de 8 anos, origem africana, com febre recorrente desde os 5 anos e três internamentos com febre, dor abdominal e elevação dos reagentes de fase aguda. No primeiro episódio foi sujeita a apendicectomia e no terceiro o quadro clínico acompanhou-se de mialgias, púrpura e proteinúria não nefrótica. A biopsia renal foi compatível com nefrite de Henoch-Schönlein. Durante os episódios de febre e dor abdominal registou-se um nível sérico de amilóide A - 92 mg/L (VR < 6.8) que levantou a suspeita de FMF. Posteriormente o diagnóstico foi confirmado por estudo genético (homozigotia para M694V no gene MEFV). Iniciou colchicina e actualmente encontra-se em remissão completa. A FMF deve ser considerada no diagnóstico diferencial de febre e dor abdominal recorrente na criança, mesmo quando a forma de apresentação é atípica (p.e. Protracted Febrile Myalgia Syndrome). O estudo genético permite confirmar o diagnóstico e tem valor em termos de prognóstic

    kawasaki disease in a young infant: diagnostic challenges

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    Kawasaki disease (KD) is a multisystem vasculitis condition with a relatively unknown etiology. It has a high prevalence in children ages 6 months to 5 years, and patients often present with high fever, rash, cervical lymphadenopathy and mucocutaneous abnormalities. Visceral manifestations can be present, being coronary complications the most frequent. There is no diagnostic test for KD, its presentation can be complete or incomplete and, in some cases, it can be atypical. We report a case of a 3-month-old infant with 3-weeks of fever and aseptic meningitis. Infectious diseases were excluded and there was no response to antibiotics. Echocardiography was normal in the second week. Genetic test for CINCA syndrome was negative. In the third week, dilatation of coronary arteries determined Kawasaki disease’s diagnosis. Prolonged fever, accompanied by nonspecific clinical symptoms were the only manifestations, becoming a challenging diagnosis. KD must be considered when prolonged fever is present, mainly in young children in whom the incomplete forms of the disease are more frequent

    Short-term versus long-term changes in the benthic communities of a small coastal lagoon: implications for ecological status assessment

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    The characteristic high variability and low predictability of coastal lagoons, due to strong changes in marine and freshwater inputs, make these ecosystems an interesting casestudy. The small Melides landlocked coastal lagoon in SW Portugal is a paradigmatic example, with a biological community highly stressed by these phenomena. Benthic macroinvertebrate samples were collected in 1998/99 and 2009 and each year, in different seasons and addressing different environmental conditions influenced by the connection to the sea and rainfall regime. Major spatial and temporal patterns in benthic communities were investigated using some invertebrate attributes (e.g. community composition, density, species richness and diversity). A very low taxonomic species richness and diversity was found in the Melides lagoon and only a much reduced number of species occurred along all sampling periods and in both sampling campaigns. Although the colonization events play a crucial role, the persistence of the observed species was mainly associated to abiotic factors, such as salinity, temperature and dissolved oxygen. Despite the potential reduction in anthropogenic pressure, by the construction of a sewage treatment plant and a reduction of urban occupation, the ecological status did not improve and the high level of natural environmental variably in the lagoon seems to be the dominant stressor influencing benthic invertebrate communitie

    Perfeccionismo no transtorno obsessivo-compulsivo e nos transtornos alimentares

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    OBJETIVO: Este estudo tem dois objetivos principais. Primeiro, avaliar as dimensões do perfeccionismo no transtorno obsessivo-compulsivo e nos transtornos alimentares em comparação com duas amostras controle: psiquiátrica (depressão/ansiedade) e não clínica. Segundo, avaliar se o perfeccionismo é um traço de personalidade especificamente relacionado com estas diferentes condições clínicas. MÉTODO: 39 pacientes com transtorno obsessivo-compulsivo, 24 com transtornos alimentares, 65 com um diagnóstico de depressão e/ou ansiedade (todos estes pacientes encontravam-se em regime de ambulatório) e 70 controles não clínicos completaram a versão portuguesa da Multidimensional Perfectionism Scale. RESULTADOS: Comparativamente à amostra não clínica, todas as amostras clínicas apresentaram níveis significativamente mais elevados na Multidimensional Perfectionism Scale total, no Perfeccionismo Auto-Orientado e no Perfeccionismo-Socialmente-Prescrito. Não houve diferenças estatisticamente significativas no Perfeccionismo-Auto-Orientado e na Multidimensional Perfectionism Scale total nas três amostras clínicas. No entanto, a amostra com transtornos alimentares apresentou níveis significativamente mais elevados de Perfeccionismo-Socialmente-Prescrito, comparativamente à transtornos alimentares e à amostra psiquiátrica (depressão/ansiedade). CONCLUSÃO: O perfeccionismo revelou estar associado a uma grande variedade de condições psicopatológicas. Contudo, as diferenças encontradas entre a amostra de transtornos alimentares, de transtorno obsessivo-compulsivo e a psiquiátrica no Perfeccionismo-Socialmente-Prescrito necessitam de investigação subsequente no sentido de clarificar a especificidade desta dimensão com os transtornos alimentares
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