13 research outputs found
El grupo polĂtico y la camarilla de Vicente Fox: formaciĂłn, consolidaciĂłn y ascenso al poder polĂtico, 1995 - 2006
“EL FEDERALISMO MEXICANO Y EL REGIMEN POLITICO EN EL DISTRITO FEDERAL: UN BALANCE EN EL CONTEXTO DEL DESAFUERO DEL JEFE DE GOBIERNO, 2004-2005”
Impact of treatment in long-term survival patients with follicular lymphoma: A Spanish Lymphoma Oncology Group registry.
BACKGROUND:Follicular lymphoma is the second most common non-Hodgkin lymphoma in the United States and Europe. However, most of the prospective randomized studies have very little follow-up compared to the long natural history of the disease. The primary aim of this study was to investigate the long-term survival of our series of patients with follicular lymphoma. PATIENTS AND METHODS:A total of 1074 patients with newly diagnosed FL were enrolled. Patients diagnosed were prospectively enrolled from 1980 to 2013. RESULTS:Median follow-up was 54.9 months and median overall survival is over 20 years in our series. We analyzed the patients who are still alive beyond 10 years from diagnosis in order to fully assess the prognostic factors that condition this group. Out of 166 patients who are still alive after more than 10 years of follow-up, 118 of them (73%) are free of evident clinical disease. Variables significantly associated with survival at 10 years were stage < II (p <0.03), age < 60 years (p <0.0001), low FLIPI (p <0.002), normal β2 microglobulin (p <0.005), no B symptoms upon diagnosis (p <0.02), Performance Status 0-1 (p <0.03) and treatment with anthracyclines and rituximab (p <0.001), or rituximab (p <0.0001). CONCLUSIONS:A longer follow-up and a large series demonstrated a substantial population of patients with follicular lymphoma free of disease for more than 10 years
Variables significantly associated with survival at 10 years.
<p>Variables significantly associated with survival at 10 years.</p
Overall survival (in months) according to performance status ECOG (B) and FLIPI score at diagnosis (C) for all patients (n = 1074).
<p>Overall survival (in months) according to performance status ECOG (B) and FLIPI score at diagnosis (C) for all patients (n = 1074).</p
Results of univariate analysis of different prognostic factors in the whole population of 1074 patients with follicular lymphoma (FL).
<p>The table shows the statistically significant prognostic factors.</p
Correlation between group of age and HR value, obtained by Cox model.
<p>HR indicates hazard risk and R<sup>2</sup>explains the great correlation between HR and age, with less than a 5% error.</p
Multivariate analysis: Characteristics associated with overall survival.
<p>Multivariate analysis: Characteristics associated with overall survival.</p
Age distribution at time of diagnosis of follicular lymphoma for all patients.
<p>Correlation between age, mortality, and risk of death, taking as reference group the group aged 20–29 years.</p