On the origin of tropospheric ozone and NOx over the tropical South Pacific

The budgets of ozone and nitrogen oxides (NOx = NO + NO2) in the tropical South Pacific troposphere are analyzed by photochemical point modeling of aircraft observations at 0-12 km altitude from the Pacific Exploratory Mission-Tropics A campaign flown in September-October 1996. The model reproduces the observed NO2/NO concentration ratio to within 30% and has similar success in simulating observed concentrations of peroxides (H2O2, CH3OOH), lending confidence in its use to investigate ozone chemistry. It is found that chemical production of ozone balances only half of chemical loss in the tropospheric column over the tropical South Pacific. The net loss is 1.8 x 1011 molecules cm-2 s-1. The missing source of ozone is matched by westerly transport of continental pollution into the region. Independent analysis of the regional ozone budget with a global three-dimensional model corroborates the results from the point model and reveals the importance of biomass burning emissions in South America and Africa for the ozone budget over the tropical South Pacific. In this model, biomass burning increases average ozone concentrations by 7-8 ppbv throughout the troposphere. The NOx responsible for ozone production within the South Pacific troposphere below 4 km can be largely explained by decomposition of peroxyacetylnitrate (PAN) transported into the region with biomass burning pollution at higher altitudes. Copyright 1999 by the American Geophysical Union

Generalized iterated wreath products of symmetric groups and generalized rooted trees correspondence

Consider the generalized iterated wreath product $S_{r_1}\wr \ldots \wr S_{r_k}$ of symmetric groups. We give a complete description of the traversal for the generalized iterated wreath product. We also prove an existence of a bijection between the equivalence classes of ordinary irreducible representations of the generalized iterated wreath product and orbits of labels on certain rooted trees. We find a recursion for the number of these labels and the degrees of irreducible representations of the generalized iterated wreath product. Finally, we give rough upper bound estimates for fast Fourier transforms.Comment: 18 pages, to appear in Advances in the Mathematical Sciences. arXiv admin note: text overlap with arXiv:1409.060

Perceptions of values over time and why they matter

Objective: Extant research mostly treats values as being stable over time. Our research examined how people perceive values over time and whether or not these perceptions reflect motivational tensions between theoretically opposing values. We also assessed the viability of examining values over time to predict well-being and future intentions. Method: Four studies (N=934) asked participants to report their values across past, present, and future settings. These temporal trajectories were analysed across the four types of higher-order values: self-transcendence, self-enhancement, openness and conservation (Schwartz, 1992). Studies 3 and 4 assessed associations with well-being. Study 4 assessed associations with self-reported behaviour over time. Results: Across all four studies, participants perceived their values as being dynamic over time. Younger participants’ trajectories did not reflect the motivational conflicts typically reported in values research, but Study 4 showed potential awareness in older age groups. Variability in temporal values correlated with well-being, particularly for openness values. Future values predicted future intentions, even when controlling for present values. Conclusion: This novel method of examining values provides new understanding into how people perceive the pursuit of values over time. Additionally, we show two ways that a temporal values measure can offer new insights into well-being and future intentions

On the kinematics of the Local cosmic void

We collected the existing data on the distances and radial velocities of galaxies around the Local Void in the Aquila/Hercules to examine the peculiar velocity field induced by its underdensity. A sample of 1056 galaxies with distances measured from the Tip of the Red Giant Branch, the Cepheid luminosity, the SNIa luminosity, the surface brightness fluctuation method, and the Tully-Fisher relation has been used for this purpose. The amplitude of outflow is found to be ~300 km/s. The galaxies located within the void produce the mean intra-void number density about 1/5 of the mean external number density of galaxies. The void's population has a lower luminosity and a later morphological type with the medians: M_B = -15.7^m and T = 8 (Sdm), respectively.Comment: Version 1. 14 pages, 8 figures, 2 tables. Accepted to Astrophysics, Volume 54, Issue

Towards the glueball spectrum from unquenched lattice QCD

We use a variational technique to study heavy glueballs on gauge configurations generated with 2+1 flavours of ASQTAD improved staggered fermions. The variational technique includes glueball scattering states. The measurements were made using 2150 configurations at 0.092 fm with a pion mass of 360 MeV. We report masses for 10 glueball states. We discuss the prospects for unquenched lattice QCD calculations of the oddballs.Comment: 19 pages, 4 tables and 8 figures. One figure added. Now matches the published versio

Absence of sign problem in two-dimensional N=(2,2) super Yang-Mills on lattice

We show that N=(2,2) SU(N) super Yang-Mills theory on lattice does not have sign problem in the continuum limit, that is, under the phase-quenched simulation phase of the determinant localizes to 1 and hence the phase-quench approximation becomes exact. Among several formulations, we study models by Cohen-Kaplan-Katz-Unsal (CKKU) and by Sugino. We confirm that the sign problem is absent in both models and that they converge to the identical continuum limit without fine tuning. We provide a simple explanation why previous works by other authors, which claim an existence of the sign problem, do not capture the continuum physics.Comment: 27 pages, 24 figures; v2: comments and references added; v3: figures on U(1) mass independence and references added, to appear in JHE

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in part, to be induced by phosphate imbalance. The molecular mechanisms that regulate VC are not fully known. Here we propose a novel role for the mineralisation regulator Ucma/GRP (Upper zone of growth plate and Cartilage Matrix Associated protein/Gla Rich Protein) in phosphate-induced VSMC calcification. We show that Ucma/GRP is present in calcified atherosclerotic plaques and highly expressed in calcifying VSMCs in vitro. VSMCs from Ucma/GRP(-/-) mice showed increased mineralisation and expression of osteo/chondrogenic markers (BMP-2, Runx2, beta-catenin, p-SMAD1/5/8, ALP, OCN), and decreased expression of mineralisation inhibitor MGP, suggesting that Ucma/GRP is an inhibitor of mineralisation. Using BMP signalling inhibitor noggin and SMAD1/5/8 signalling inhibitor dorsomorphin we showed that Ucma/GRP is involved in inhibiting the BMP-2-SMAD1/5/8 osteo/chondrogenic signalling pathway in VSMCs treated with elevated phosphate concentrations. Additionally, we showed for the first time evidence of a direct interaction between Ucma/GRP and BMP-2. These results demonstrate an important role of Ucma/GRP in regulating osteo/chondrogenic differentiation and phosphate-induced mineralisation of VSMCs.NWO ZonMw [MKMD 40-42600-98-13007]; FCT [SFRH/BPD/70277/2010]info:eu-repo/semantics/publishedVersio

From von Neumann architecture and Atanasoff’s ABC to Neuromorphic Computation and Kasabov’s NeuCube. Part II: Applications

Spatio/Spector-Temporal Data (SSTD) analyzing is a challenging task, as temporal features may manifest complex interactions that may also change over time. Making use of suitable models that can capture the “hidden” interactions and interrelationship among multivariate data, is vital in SSTD investigation. This chapter describes a number of prominent applications built using the Kasabov’s NeuCube-based Spiking Neural Network (SNN) architecture for mapping, learning, visualization, classification/regression and better understanding and interpretation of SSTD

Competing biosecurity and risk rationalities in the Chittagong poultry commodity chain, Bangladesh

This paper anthropologically explores how key actors in the Chittagong live bird trading network perceive biosecurity and risk in relation to avian influenza between production sites, market maker scenes and outlets. They pay attention to the past and the present, rather than the future, downplaying the need for strict risk management, as outbreaks have not been reported frequently for a number of years. This is analysed as ‘temporalities of risk perception regarding biosecurity’, through Black Swan theory, the idea that unexpected events with major effects are often inappropriately rationalized (Taleb in The Black Swan. The impact of the highly improbable, Random House, New York, 2007). This incorporates a sociocultural perspective on risk, emphasizing the contexts in which risk is understood, lived, embodied and experienced. Their risk calculation is explained in terms of social consent, practical intelligibility and convergence of constraints and motivation. The pragmatic and practical orientation towards risk stands in contrast to how risk is calculated in the avian influenza preparedness paradigm. It is argued that disease risk on the ground has become a normalized part of everyday business, as implied in Black Swan theory. Risk which is calculated retrospectively is unlikely to encourage investment in biosecurity and, thereby, points to the danger of unpredictable outlier events

Mapping gene associations in human mitochondria using clinical disease phenotypes

Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical phenotypes. Such a catalog would be useful to develop methods to analyze human phenotypic data, to determine genotype-phenotype relations among many genes and diseases, and to support the clinical diagnosis of mitochondrial disorders. Here we establish a clinical phenotype catalog of 174 mitochondrial disease genes and study associations of diseases and genes. Phenotypic features such as clinical signs and symptoms were manually annotated from full-text medical articles and classified based on the hierarchical MeSH ontology. This classification of phenotypic features of each gene allowed for the comparison of diseases between different genes. In turn, we were then able to measure the phenotypic associations of disease genes for which we calculated a quantitative value that is based on their shared phenotypic features. The results showed that genes sharing more similar phenotypes have a stronger tendency for functional interactions, proving the usefulness of phenotype similarity values in disease gene network analysis. We then constructed a functional network of mitochondrial genes and discovered a higher connectivity for non-disease than for disease genes, and a tendency of disease genes to interact with each other. Utilizing these differences, we propose 168 candidate genes that resemble the characteristic interaction patterns of mitochondrial disease genes. Through their network associations, the candidates are further prioritized for the study of specific disorders such as optic neuropathies and Parkinson disease. Most mitochondrial disease phenotypes involve several clinical categories including neurologic, metabolic, and gastrointestinal disorders, which might indicate the effects of gene defects within the mitochondrial system. The accompanying knowledgebase (http://www.mitophenome.org/) supports the study of clinical diseases and associated genes