Uncooled Microbolometer Arrays for Ground Based Astronomy

We describe the design and commissioning of a simple prototype, low-cost 10 μm imaging instrument. The system is built using commercially available components including an uncooled microbolometer array as a detector. The incorporation of adjustable germanium reimaging optics rescale the image to the appropriate plate scale for the 2 m diameter Liverpool Telescope. From observations of bright Solar system and stellar sources, we demonstrate a plate scale of 0.75 arcsec per pixel and confirm the optical design allows diffraction limited imaging. We record a ∼10 percent photometric stability due to sky variability. We measure a 3σ sensitivity of 7 × 103 Jy for a single, ∼0.11 s exposure. This corresponds to a sensitivity limit of 3 × 102 Jy for a 60 s total integration. We present an example science case from observations of the 2019 January total lunar eclipse and show that the system can detect and measure the anomalous cooling rate associated with the features Bellot and Langrenus during eclipse

Liverpool Telescope 2: a new robotic facility for time domain astronomy in 2020

The robotic 2m Liverpool Telescope, based on the Canary island of La Palma, has a diverse instrument suite and a strong track record in time domain science, with highlights including early time photometry and spectra of supernovae, measurements of the polarization of gamma-ray burst afterglows, and high cadence light curves of transiting extrasolar planets. In the next decade the time domain will become an increasingly prominent part of the astronomical agenda with new facilities such as LSST, SKA, CTA and Gaia, and promised detections of astrophysical gravitational wave and neutrino sources opening new windows on the transient universe. To capitalise on this exciting new era we intend to build Liverpool Telescope 2: a new robotic facility on La Palma dedicated to time domain science. The next generation of survey facilities will discover large numbers of new transient sources, but there will be a pressing need for follow-up observations for scientific exploitation, in particular spectroscopic follow-up. Liverpool Telescope 2 will have a 4-metre aperture, enabling optical/infrared spectroscopy of faint objects. Robotic telescopes are capable of rapid reaction to unpredictable phenomena, and for fast-fading transients like gamma-ray burst afterglows. This rapid reaction enables observations which would be impossible on less agile telescopes of much larger aperture. We intend Liverpool Telescope 2 to have a world-leading response time, with the aim that we will be taking data with a few tens of seconds of receipt of a trigger from a ground- or space-based transient detection facility. We outline here our scientific goals and present the results of our preliminary optical design studies. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

A low-cost chopping system and uncooled microbolometer array for ground-based astronomy

Mid-Infrared imaging is vital for the study of a wide variety of astronomical phenomena, including evolved stars, exoplanets, and dust enshrouded processes such as star formation in galaxies. However, infrared detectors have traditionally been expensive and it is difficult to achieve the sensitivity needed to see beyond the overwhelming mid-infrared background. Here we describe the upgrade and commissioning of a simple prototype, low-cost 10 μ m imaging instrument. The system was built using commercially available components including an uncooled microbolometer focal plane array and chopping system. The system was deployed for a week on the 1.52 m Carlos Sanchez Telescope and used to observe several very bright mid-infrared sources with catalogue fluxes down to ∼600 Jy. We report a sensitivity improvement of ∼4 mag over our previous unchopped observations, in line with our earlier predictions

Thaptomys Thomas 1915 (Rodentia, Sigmodontinae, Akodontini) with karyotypes 2n = 50, FN = 48, and 2n = 52, FN = 52: Two monophyletic lineages recovered by molecular phylogeny

A novel karyotype with 2n = 50, FN = 48, was described for specimens of Thaptomys collected at Una, State of Bahia, Brazil, which are morphologically indistinguishable from Thaptomys nigrita, 2n = 52, FN = 52, found in other localities. It was hence proposed that the 2n = 50 karyotype could belong to a distinct species, cryptic of Thaptomys nigrita, once chromosomal rearrangements observed, along with the geographic distance, might represent a reproductive barrier between both forms. Phylogenetic analyses using maximum parsimony and maximum likelihood based on partial cytochrome b sequences with 1077 bp were performed, attempting to establish the relationships among the individuals with distinct karyotypes along the geographic distribution of the genus; the sample comprised 18 karyotyped specimens of Thaptomys, encompassing 15 haplotypes, from eight different localities of the Atlantic Rainforest. The intra-generic relationships corroborated the distinct diploid numbers, once both phylogenetic reconstructions recovered two monophyletic lineages, a northeastern clade grouping the 2n = 50 and a southeastern clade with three subclades, grouping the 2n = 52 karyotype. The sequence divergence observed between their individuals ranged from 1.9% to 3.5%

Liverpool Telescope 2: beginning the design phase

The Liverpool Telescope is a fully robotic 2-metre telescope located at the Observatorio del Roque de los Muchachos on the Canary Island of La Palma. The telescope began routine science operations in 2004, and currently seven simultaneously mounted instruments support a broad science programme, with a focus on transient followup and other time domain topics well suited to the characteristics of robotic observing. Work has begun on a successor facility with the working title ‘Liverpool Telescope 2’. We are entering a new era of time domain astronomy with new discovery facilities across the electromagnetic spectrum, and the next generation of optical survey facilities such as LSST are set to revolutionise the field of transient science in particular. The fully robotic Liverpool Telescope 2 will have a 4-metre aperture and an improved response time, and will be designed to meet the challenges of this new era. Following a conceptual design phase, we are about to begin the detailed design which will lead towards the start of construction in 2018, for first light ∼2022. In this paper we provide an overview of the facility and an update on progress. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Alcohol consumption and lifetime change in cognitive ability:a gene × environment interaction study

Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design. Here, we used such a design to test the hypothesis that a genetic score for alcohol processing capacity moderates the association between alcohol consumption and lifetime change in cognitive ability. Members of the Lothian Birth Cohort 1936 completed the same test of intelligence at age 11 and 70 years. They were assessed for recent alcohol consumption in later life and genotyped for a set of four single-nucleotide polymorphisms in three alcohol dehydrogenase genes. These variants were unrelated to late-life cognition or to socioeconomic status. We found a significant gene × alcohol consumption interaction on lifetime cognitive change (p = 0.007). Individuals with higher genetic ability to process alcohol showed relative improvements in cognitive ability with more consumption, whereas those with low processing capacity showed a negative relationship between cognitive change and alcohol consumption with more consumption. The effect of alcohol consumption on cognitive change may thus depend on genetic differences in the ability to metabolize alcohol

Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide

In Paracoccus denitrificans, three CRP/FNR family regulatory proteins, NarR, NnrR and FnrP, control the switch between aerobic and anaerobic (denitrification) respiration. FnrP is a [4Fe-4S] cluster containing homologue of the archetypal O2 sensor FNR from E. coli and accordingly regulates genes encoding aerobic and anaerobic respiratory enzymes in response to O2, and also NO, availability. Here we show that FnrP undergoes O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion that involves up to 2 O2 per cluster, with significant oxidation of released cluster sulfide to sulfane observed at higher O2 concentrations. The rate of the cluster reaction was found to be ~6-fold lower than that of E. coli FNR, suggesting that FnrP can remain transcriptionally active under microaerobic conditions. This is consistent with a role for FnrP in activating expression of the high O2 affinity cytochrome c oxidase under microaerobic conditions. Cluster conversion resulted in dissociation of the transcriptionally active FnrP dimer into monomers. Therefore, along with E. coli FNR, FnrP belongs to the subset of FNR proteins in which cluster type is correlated with association state. Interestingly, two key charged residues, Arg140 and Asp154, that have been shown to play key roles in the monomer-dimer equilibrium in E. coli FNR are not conserved in FnrP, indicating that different protomer interactions are important for this equilibrium. Finally, the FnrP [4Fe-4S] cluster is shown to undergo reaction with multiple NO molecules, resulting in iron nitrosyl species and dissociation into monomers

Adenocarcinoma of the caecum metastatic to the bladder: an unusual cause of haematuria

BACKGROUND: Primary malignancies of colorectal origin can metastasise to the bladder. Reports are however extremely rare, particularly from the caecum. CASE REPORT: The report describes the case of a 45-year old male with Duke's B caecal carcinoma treated with a laparoscopically-assisted right hemicolectomy and adjuvant 5-Fluorouracil chemotherapy. Subsequently, a metastatic lesion to the bladder was demonstrated and successfully excised by partial cystectomy. CONCLUSION: In order that optimal therapeutic options can be determined, it is important for clinicians to distinguish between primary disease of the bladder and other causes of haematuria. Various immunohistochemical techniques attempt to differentiate primary adenocarcinoma of the bladder from secondary colorectal adenocarcinoma. Suspicion of metastatic disease must be raised when histologically unusual bladder tumours are identified