Perbandingan Hasil Belajar IPA Siswa Antara Model Pembelajaran Berbasis Masalah Dengan Model Pembelajaran Inkuiri Terbimbing

The objective of this research is to find out the comparison of students’ natural science learning results in heat material using problem based learning and inquiry based learning, and to find out the highest learning results amongst problem based learning and inquiry based learning.This is a quasi experiment research with one-group pretest-post test design. Samples were 61 students in grade VII of classroom VIIA and VIIB in State Junior High School 22 in Bandar Lampung. Samples were taken using purposive sampling technique. Data were obtained from learning results of student’s post test. Data were analyzed using data normality test, estimating score N-gain, and dependent sample t-test.The results conclude that there is an improvement of average of students’ learning results by using problem based learning and inquiry based learning. The students learning results in problem based learning is higher than in inquiry based learning. The abilities of students having problem based learning are better than those who have inquiry based learning

Pengaruh Kompos Kotoran Kuda terhadap Pertumbuhan Kacang Panjang (Phaseolus Vulgaris L)

Penelitian tentang pengaruh kompos terhadap pertumbuhan kacang panjang, telah dilaksanakan di Desa Sukarare Kabupaten Lombok Tengah. Tujuan dilaksanakannya penelitian ini adalah untuk mengetahui: (1) pengaruh kompos terhadap pertumbuhan kacang panjang pada lahan pertanian Desa Sukarare, (2) dosis kompos yang perlu diberikan pada lahan pertanian Desa Sukarare agar tanaman kacang panjang tumbuh secara optimal. Dalam penelitian ini digunakan rancangan acak kelompok dengan delapan ulangan. Data penelitian dianalisis dengan analisis sidik ragam dan uji lanjut dengan Uji Beda Nyata Terkecil (BNT). Hasil penelitian menunjukkan bahwa (1) penggunaan kompos pada lahan pertanian Desa Sukarare berpengaruh nyata terhadap pertumuhan kacang panjang, (2) kadar optimum kompos yang perlu diberikan pada lahan pertanian Desa Sukarare agar kacang panjang tumbuh secara optimal adalah 2,0 kg untuk setiap 1 m2 lahan pertanian Kata

PELATIHAN BLENDED LEARNING MENGGUNAKAN VIRTUAL LABORATORY BERBASIS PHET INTERACTIVE SIMULATION DI SMAS YPK MERAUKE

ABSTRAKPeningkatan ilmu pengetahuan dan teknologi saat ini tak dapat dipisahkan dari dunia pendidikan. Banyak kebutuhan pendidikan yang dapat dipenuhi dengan memanfaatkan teknologi dalam pembelajaran, salah satunya adalah kebutuhan untuk melaksanakan praktikum. Masalah umum yang dialami guru IPA dalam pembelajaran adalah minimnya peralatan laboratorium untuk melaksanakan praktikum. Kegiatan pengabdian ini bertujuan untuk melatih guru-guru agar mampu memanfaatkan PhET Interactive Simulation dalam laboratorium virtual untuk kegiatan praktikum. Metode yang digunakan adalah pelatihan dalam bentuk presentasi berupa pemaparan mengenai PhET Interactive Simulation, pelatihan, evaluasi, dan pendampingan secara langsung kepada para guru yang masih mengalami kesulitan. Dari kegiatan pelatihan ini diperoleh hasil bahwa 90% guru telah mampu mengoperasikan kegiatan praktikum virtual menggunakan peralatan yang tersedia dalam PhET Interactive Simulation. Sejumlah 10% guru lainnya sudah mampu membuka PhET Interactive Simulation namun masih kesulitan mengoperasikan kegiatan praktikum virtualnya. Kata kunci: PhET Interactive Simulation; laboratorium virtual; praktikum ABSTRACTIncreasing science and technology today cannot be separated from the world of education. Many educational needs can be met by utilizing technology in learning, one of which is the need to carry out practicums. A common problem experienced by science teachers in learning is the lack of laboratory equipment to carry out practicums. This service activity aims to train teachers to be able to utilize PhET Interactive Simulation in a virtual laboratory for practicum activities. The method used is training in the form of presentations in the form of exposure to PhET Interactive Simulation, training, evaluation, and direct assistance to teachers who are still experiencing difficulties. From this training activity, the result was that 90% of teachers were able to operate virtual practicum activities using the equipment available in the PhET Interactive Simulation. Another 10% of teachers have been able to open PhET Interactive Simulation but still have difficulty operating their virtual practicum activities. Keywords: PhET Interactive Simulation; virtual laboratory; practicu

PEMANFAATAN MODEL JURNAL BELAJAR KOTAK BERHIAS UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR

Telah dilaksanakan penelitian yang bertujuan untuk menguji efektivitas jurnal belajar model kotak berhias (JBMKB) dalam meningkatkan motivasi dan hasil belajar siswa. Penelitian dilaksanakan dengan pola kuasi eksperimen dengan nonequivalent kontrol group design. Subjek penelitian adalah seluruh siswa kelas X SMA Negeri 2 Labuapi tahun ajaran 2016/2017 yang berjumlah 118 siswa. Teknik pengambilan sampel dilakukan dengan teknik purposive sampling sehingga terpilih kelas X IPA 1 dan kelas X IPA 2 sebagai kelas eksperimen dan kontrol. Instrumen yang digunakan untuk memperoleh data penelitian adalah angket motivasi belajar dan tes hasil belajar kognitif. Hasil penelitian menunjukkan bahwa: 1) JBMKB efektif dalam meningkatkan motivasi belajar (p-value = 0,00 < α = 0,05) dan 2) hasil belajar siswa (p-value = 0,00 < α = 0,05). Dapat disimpulkan bahwa jurnal belajar model kotak berhias efektif dalam meningkatkan motivasi dan hasil belajar siswa.Kata Kunci: JBMKB, motivasi, hasil belajar, kogniti

Efficacy and feasibility of proton beam therapy in relapsed high-risk neuroblastoma-experiences from the prospective KiProReg registry

BACKGROUND: Despite an intensive multimodal treatment approach, approximately 50% of high-risk (HR) neuroblastoma (NB) patients experience progression. Despite the advances in targeted therapy, high-dose chemotherapy, and other systemic treatment options, radiation therapy (RT) to sites of relapsed disease can be an option to reduce tumor burden and improve chance for disease control. METHODS: Patients who received salvage irradiation with proton beam therapy (PBT) for local or metastatic relapse of HR NB within the prospective registry trials KiProReg and ProReg were eligible for this retrospective analysis. Data on patient characteristics, multimodality therapy, adverse events, and oncologic endpoints were evaluated. Adverse events were assessed before, during, and after PBT according to common terminology criteria for adverse events (CTCAE) V4.0. RESULTS: Between September 2013 and September 2020, twenty (11 male; 9 female) consecutive patients experiencing local (N = 9) or distant recurrence (N = 25) were identified for this analysis. Distant recurrences included osteomedullary (N = 11) or CNS lesions (N = 14). Salvage therapy consisted of re-induction chemo- or chemo-immuno-therapy (N = 19), surgery (N = 6), high-dose chemotherapy and stem cell transplantation (N = 13), radiation (N = 20), and concurrent systemic therapy. Systemic therapy concurrent to RT was given to six patients and included temozolomide (N = 4), carboplatine (N = 1), or anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKI) (N = 1). A median dose of 36 Gy was applied to the 34 recurrent sites. Local RT was applied to 15 patients, while five patients, received craniospinal irradiation for CNS relapse. After a median follow-up (FU) of 20 months (4-66), the estimated rate for local control, distant metastatic free survival, and overall survival at 3 years was 68.0%, 37.9%, and 61.6%, respectively. During RT, ten patients (50%) presented with a higher-grade acute hematologic adverse event. Late higher-grade sequelae included transient myelitis with transverse section (N = 2) and secondary malignancy outside of the RT field (N = 1). CONCLUSION: Our study demonstrates the efficacy and safety of RT/PBT for recurrent HR NB in a multimodality second-line approach. To better define the role of RT for these patients, prospective studies would be desirable

A Distinct Urinary Biomarker Pattern Characteristic of Female Fabry Patients That Mirrors Response to Enzyme Replacement Therapy

Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase A gene, is available and no biomarker has been proven useful to screen for the disease, predict disease course and monitor response to enzyme replacement therapy. Here, we used urine proteomic analysis based on capillary electrophoresis coupled to mass spectrometry and identified a biomarker profile in adult female Fabry patients. Urine samples were taken from 35 treatment-naive female Fabry patients and were compared to 89 age-matched healthy controls. We found a diagnostic biomarker pattern that exhibited 88.2% sensitivity and 97.8% specificity when tested in an independent validation cohort consisting of 17 treatment-naive Fabry patients and 45 controls. The model remained highly specific when applied to additional control patients with a variety of other renal, metabolic and cardiovascular diseases. Several of the 64 identified diagnostic biomarkers showed correlations with measures of disease severity. Notably, most biomarkers responded to enzyme replacement therapy, and 8 of 11 treated patients scored negative for Fabry disease in the diagnostic model. In conclusion, we defined a urinary biomarker model that seems to be of diagnostic use for Fabry disease in female patients and may be used to monitor response to enzyme replacement therapy

Frequency of Fabry disease in male and female haemodialysis patients in Spain

<p>Abstract</p> <p>Background</p> <p>Fabry disease (FD), an X-linked lysosomal storage disorder, is caused by a reduced activity of the lysosomal enzyme α-galactosidase A. The disorder ultimately leads to organ damage (including renal failure) in males and females. However, heterozygous females usually present a milder phenotype with a later onset and a slower progression.</p> <p>Methods</p> <p>A combined enzymatic and genetic strategy was used, measuring the activity of α-galactosidase A and genotyping the α-galactosidase A gene (<it>GLA</it>) in dried blood samples (DBS) of 911 patients undergoing haemodialysis in centers across Spain.</p> <p>Results</p> <p><it>GLA </it>alterations were found in seven unrelated patients (4 males and 3 females). Two novel mutations (p.Gly346AlafsX347 and p.Val199GlyfsX203) were identified as well as a previously described mutation, R118C. The R118C mutation was present in 60% of unrelated patients with <it>GLA </it>causal mutations. The D313Y alteration, considered by some authors as a pseudo-deficiency allele, was also found in two out of seven patients.</p> <p>Conclusions</p> <p>Excluding the controversial D313Y alteration, FD presents a frequency of one in 182 individuals (0.55%) within this population of males and females undergoing haemodialysis. Moreover, our findings suggest that a number of patients with unexplained and atypical symptoms of renal disease may have FD. Screening programmes for FD in populations of individuals presenting severe kidney dysfunction, cardiac alterations or cerebrovascular disease may lead to the diagnosis of FD in those patients, the study of their families and eventually the implementation of a specific therapy.</p