Mild Sensory Stimulation Completely Protects the Adult Rodent Cortex from Ischemic Stroke

Despite progress in reducing ischemic stroke damage, complete protection remains elusive. Here we demonstrate that, after permanent occlusion of a major cortical artery (middle cerebral artery; MCA), single whisker stimulation can induce complete protection of the adult rat cortex, but only if administered within a critical time window. Animals that receive early treatment are histologically and behaviorally equivalent to healthy controls and have normal neuronal function. Protection of the cortex clearly requires reperfusion to the ischemic area despite permanent occlusion. Using blood flow imaging and other techniques we found evidence of reversed blood flow into MCA branches from an alternate arterial source via collateral vessels (inter-arterial connections), a potential mechanism for reperfusion. These findings suggest that the cortex is capable of extensive blood flow reorganization and more importantly that mild sensory stimulation can provide complete protection from impending stroke given early intervention. Such non-invasive, non-pharmacological intervention has clear translational potential

Guidelines for management of ischaemic stroke and transient ischaemic attack 2008

This article represents the update of the European Stroke Initiative Recommendations for Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic attacks, which are now considered to be a single entity. The article covers referral and emergency management, Stroke Unit service, diagnostics, primary and secondary prevention, general stroke treatment, specific treatment including acute management, management of complications, and rehabilitation

Mid-dermis Grafting—A Clinical Study

Twenty two patients requiring skin coverage were subjected to mid-dermis grafting. Thirty one mid-dermis grafts were applied and all the patients had simultaneous controls provided by split skin grafts. Take up of grafts was reasonably good. Mid-dermis grafts were permanent, and more stable then split skin. The greatest advantage lay in doubling the donor site potential

Giant Rhinolith (A Report of 3 Cases)

Three cases of giant rhinoliths are described causing destruction of the nasal septum and lateral wall of the nose. No previous history of foreign body was present. The association of rhinolith with cleft lip and palate is uncommon